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- Deepa Parashar
- N.P. Aditya
- Ramachandra Murthy Rayasa
- Kurian Mathew
- S. S. Sarkar
- A. R. Srinivas
- Moumita Dutta
- Minal x Minal Rohit
- Harish Seth
- Rajiv Kumaran
- Kshitij Pandya
- Jitendra Sharma
- Jalshri Desai
- Amul Patel
- Vishnu Patel
- Piyush Shukla
- S. Manthira Moorthi
- Aravind K. Singh
- Ashutosh Gupta
- Jaya Rathi
- P. Narayana Babu
- Saji A. Kuriakose
- D. R. M. Samudraiah
- A. S. Kiran Kumar
- Arup Roy Chowdhury
- Arup Banerjee
- S. R. Joshi
- Satadru Bhattacharya
- Amitabh
- Sami Ur Rehman
- Sunil Bhati
- J. C. Karelia
- Amiya Biswas
- Anish R. Saxena
- Satish Sharma
- Sandip R. Somani
- H. V. Bhagat
- D. N. Ghonia
- B. B. Bokarwadia
- Ajay Parasar
- Manish Saxena
- Aditya Dagar
- Manish Mittal
- Shweta Kirkire
- Dhrupesh Shah
- Anand Kumar
- Kailash Jha
- Prasanta Das
- Meghal Desai
- Gaurav Bansal
- Vishnukumar D. Patel
- A. S. Arya
- Sukamal Paul
- Pradeep Soni
- Minal Sampat
- Sandip Somani
- K. Suresh
- R. P. Rajasekhar
- Mukesh Kumar
- Joyita Thapa
- Abhik Kundu
- Rwiti Basu
- Arup Roychowdhury
- Prakash Chauhan
- Mamta Chauhan
- Prabhakar A. Verma
- Supriya Sharma
- Aditya Kumar Dagar
- Amitabh
- Abhishek N. Patil
- Ajay Kumar Parashar
- Nilesh Desai
- Ritu Karidhal
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Kumar, Ankush
- Simultaneous Estimation of Artemether and Lumefantrine in Pharmaceutical dosage forms using Derivative Spectrophotometry
Abstract Views :480 |
PDF Views:2
Authors
Affiliations
1 I.S.F. College of Pharmacy, Ferozpur, G.T. Road, Moga, Punjab
2 Food Nanotechnology Laboratory, Department of Food science and Technology, Sejong University, Seoul
1 I.S.F. College of Pharmacy, Ferozpur, G.T. Road, Moga, Punjab
2 Food Nanotechnology Laboratory, Department of Food science and Technology, Sejong University, Seoul
Source
Asian Journal of Research in Chemistry, Vol 6, No 3 (2013), Pagination: 226-231Abstract
In the present investigation a simple, rapid and accurate method for the simultaneous estimation of artemether (ART) and lumefantrine (LUM) was developed using derivative spectroscopic technique. To avoid the overlapping of ART and LUM in zero order spectra, first order spectrum was developed. ART showed good linearity with regression coefficient (r<SUP>2</SUP>) of 0.9993 over the range of 30-80μg/ml at 260 nm wavelength and LUM showed linearity over the range of 4-12µg/ml at 286.2 nm wave length with correlation coefficient (r<SUP>2</SUP> ) of 0.9999. The analytical method was validated for simultaneous estimation of ART and LUM both as drug solutions, in tablets and in NLCs and validation parameters are reported. Intercept value of the linear lines determined for ART and LUM were nearly zero. ART and LUM showed accuracy of 99.215 and 99.564 in terms of % recovery. The relative standard deviation (RSD at n=6) intra-day: Inter-day precision for ART and LUM were 0.944:1.124 and 0.890:1.009 respectively indicating the method is precise. LOD (µg/ml) and LOQ (μg/ml) values for ART were 0.3606 and 1.0928 and for LUM were 0.1145 and 0.3470 respectively. The developed method was successfully applied in the estimation of ART and LUM in commercial tablet (Arte plus CD) containing both the drugs.Keywords
Artemether, Lumefantrine, Derivative Spectroscopy, Simultaneous Estimation, ValidationReferences
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- Meshnick SR, Taylor TE, Kamchonwongpaisan S, Artimisinin and the antimalarial endoperoxides: From herbal remedy to targeted chemotherapy, Microbiological review, 1996, 60(2), 301-15.
- Chimanuka, B., Gabriels, M., Detaevernier, M.R., Plaizier- Vercammen, J.A., 2002 Preparation of beta-artemether liposomes, their HPLC-UV evaluation and relevance for clearing recrudescent parasitaemia in Plasmodium chabaudi malariainfected mice. J. Pharm. Biomed. Anal. 28, 13–22
- Aditya NP, Patankar S, Madhusudhan B, Murthy RSR, Souto EB. Artemether loaded lipid nanoparticles produced by modified-thin film hydration: Pharmacokinetics, toxicological and in vivo antimalarial activity. European Journal of Pharmaceutical Sciences.2010; 40:448-455.
- Arun R. and Anton S A. Development of analytical method for Lumefantrine by UV-Spectrophtometry. Int. J. Res. Pharm. Sci. 2010;1(3):321-4
- Shrivastava A, Nagori BP, Saini P, Issarani R, Gaur S. New Simple and Economical Spectrophotometric Method for Estimation of Artemether in Pharmaceutical Dosage Forms. Asian J. Research Chem. (2008)1, 1-19.
- Cesar C, Noqueira FH, Antonio P G. Simultaneous determination of Artemether and Lumefantrine in fixed dose combination tablets by HPLC with UV detection. . J. Pharm. Biomed. Anal. 48(1)10 2008, Pages 223–226
- Thomas CG, Ward SA, Edwards G. Selective determination, in plasma, of artemether and its major metabolite, dihydroartemisinin, by high-performance liquid chromatography with ultraviolet detection. J. Chromatogr. B 583 (1992) 131–136.
- Khalil IF, Abildrup U, Alifrangis LH, Magia D, Alifrangis M, Hoegberg L, Vestergaarde LS, Persson OP, Nyagonde N, Lemnge MM, Theander TG, Bygbierg IC. developed the measurement of Lumefantrine and its metabolite in plasma by HPLC with UV detection. J Pharm Biomed Anal, 2011 Jan 5;54(1) : 168-72.
- Gabrils M, Plaizier-Vercammen JA,. Densitometric Thin-Layer Chromatographic Determination of Artemisinin and its Lipophilic Derivatives, Artemether and Arteether. J Chromatogr Sci. (2003), 41(7):359-66.
- Gabrils M, Plaizier-Vercammen JA,. Development of a Reversed-Phase Thin-Layer Chromatographic Method for Artemisinin and Its Derivatives, .J. Chromatogr. Sci. 42 (2004) 341–347.
- Verbeken M, Sultan S, Bram B, Vangheluwe E , Sylvia VD, Christian Burvenich, Luc-Duchateau, Frans H J and Bart D S. Stability-indicating HPLC-DAD/UV- EST/MS impurity profiling of the anti-malarial drug Lumefantrine. Malarial J.2011;10: 51.
- Hulst AD, Augustijns P, Arens S, Van Parijs L, Colson S, Verbeke N, Kinget R. Determination of Artesunate by Capillary Electrophoresis with Low UV Detection and possible application to analogues. J. Chromatogr. Sci. 41 (1996)34.
- Varma J K, Syed H. A. Spectrophotometric method for determination of Lumefantrine in pharmaceutical formulation. J. Pharm. Res. 2009;2(9):1550-1.
- Beckett AH, Stenlake JB, Practical Pharmaceutical Chemistry. 4th ed. Delhi: CBS Publisher and Distributors, 1997.
- Patel PM, Suhagia BN, Shah SA, Marolia BP, Bodiwala KB, Prajapati PB, Simultaneous estimation of etoricoxib and paracetamol in the synthetic mixture and Pharmaceutical dosage forms by derivative spectophotometry, Journal of Pharmacy Research, 2010, 3(8), 1967-70.
- Donald W, A Practical handbook of preparative HPLC, Elsevier publisher, New York, 2006, p. 37-45.
- Thomas CG, Ward SA, Edwards G, J. Selective determination, in plasma, of artemether and its major metabolite, dihydroartemisinin, by high-performance liquid chromatography with ultraviolet detection, Chromatogr. 1992, 583, 131-6. Green MD, Mount DL, Wirtz RA., Authentication of artemether, artesunate and dihydroartemisinin antimalarial tablets using a simple colorimetric method., Trop. Med. Int. Health, 2001 Dec;6(12):980-82.
- Methane Sensor for Mars
Abstract Views :228 |
Authors
Kurian Mathew
1,
S. S. Sarkar
1,
A. R. Srinivas
1,
Moumita Dutta
1,
Minal x Minal Rohit
1,
Harish Seth
1,
Rajiv Kumaran
1,
Kshitij Pandya
1,
Ankush Kumar
1,
Jitendra Sharma
1,
Jalshri Desai
1,
Amul Patel
1,
Vishnu Patel
1,
Piyush Shukla
1,
S. Manthira Moorthi
1,
Aravind K. Singh
1,
Ashutosh Gupta
1,
Jaya Rathi
1,
P. Narayana Babu
1,
Saji A. Kuriakose
1,
D. R. M. Samudraiah
1,
A. S. Kiran Kumar
1
Affiliations
1 Space Applications Centre, Indian Space Research Organisation, Ahmedabad 380 058, IN
1 Space Applications Centre, Indian Space Research Organisation, Ahmedabad 380 058, IN
Source
Current Science, Vol 109, No 6 (2015), Pagination: 1087-1096Abstract
Methane Sensor for Mars (MSM), on-board Mars Orbiter Mission is a differential radiometer based on Fabry–Perot Etalon (FPE) filters which measures column density of methane in the Martian atmosphere. It is the first FPE sensor ever flown to space. Spectral, spatial and radiometric performances of the sensor were characterized thoroughly during the pre-launch calibration. Geophysical calibration of the sensor was carried out using the data acquired over Sahara desert during Earth Parking Orbit phase. Retrieval algorithm for MSM, which is based on the linearization of radiative transfer equations, gets simultaneous solutions for CH4 and CO2 concentrations in the Martian atmosphere.Keywords
Differential radiometer, Fabry–Perot Etalon, geophysical calibration, methane sensor, retrieval algorithm.Full Text
References
- Miller, J. D., Case, M. J., Straat, P. A. and Levin, G. V., Likelihood ofmethane-producing microbes on Mars. Proc. SPIE, 2010,7819, 781,901–781,906.
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- Chizek, M. R., Murphy, J. R., Fonti, S., Marzo, G. A., Kahre, M. A. and Roush, T. L., Mapping the methane on Mars: seasonal comparison. In The Fourth International Workshop on the Mars Atmosphere: Modelling and Observation, in Paris, 8–11 February 2011; http://www-mars.lmd.jussieu.fr/paris2011/ program.html
- Zahnle, K., Freedman, R. and Catling, D., Is there methane on Mars? Icarus, 2011, 212, 493–503.
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- Imaging Infrared Spectrometer onboard Chandrayaan-2 Orbiter
Abstract Views :252 |
PDF Views:87
Authors
Arup Roy Chowdhury
1,
Arup Banerjee
1,
S. R. Joshi
1,
Moumita Dutta
1,
Ankush Kumar
1,
Satadru Bhattacharya
1,
Amitabh
1,
Sami Ur Rehman
1,
Sunil Bhati
1,
J. C. Karelia
1,
Amiya Biswas
1,
Anish R. Saxena
1,
Satish Sharma
1,
Sandip R. Somani
1,
H. V. Bhagat
1,
Jitendra Sharma
1,
D. N. Ghonia
1,
B. B. Bokarwadia
1,
Ajay Parasar
1
Affiliations
1 Space Applications Centre, Indian Space Research Organisation, Ahmedabad 380 015, IN
1 Space Applications Centre, Indian Space Research Organisation, Ahmedabad 380 015, IN
Source
Current Science, Vol 118, No 3 (2020), Pagination: 368-375Abstract
Imaging Infrared Spectrometer (IIRS) is an imaging hyperspectral instrument for mineralogy of the lunar surface (including the hydroxyl signature). IIRS operates in the 0.8–5 μm spectral range with about 250 contiguous bands. It has 80 m ground sampling distance and 20 km swath at nadir from 100 km orbit altitude. Optical design is based on fore-optics and Offner (convex multi-blazed grating)-type spectrometer. Focal plane array is HgCdTe (mercury–cadmium–telluride)- based actively cooled to 90 K, having 500 × 256 pixels format with 30 μm pixel size. Electronics comprises proximity, logic and control, power supply and cooler drive electronics. Mechanical system is realized to house various subsystems, namely optics, detector, electronics and thermal components meeting the structural, opto-mechanical thermal component and alignment requirements. Thermal system is designed such that the instrument is cooled and maintained at fixed temperature to reduce and control instrument background. Aluminum-based mirror, grating and housing are developed to maintain structural as well as opto-mechanical and thermal requirements. This article presents IIRS realization and spectroradoimetric performance.Keywords
Hyperspectral Imaging, Infrared Spectrometer, Moon, Orbiter.References
- Banerjee, A. et al., SW–MW infrared spectrometer for lunar mission. In Proceedings of SPIE 9880, Multispectral, Hyperspectral, and Ultraspectral Remote Sensing Techniques and Applications VI, 98801F, 30 April 2016; doi:10.1117/12.2228225.
- Kiran Kumar, A. S. et al., Hyper Spectral Imager for lunar mineral mapping in visible and near infrared band. Curr. Sci., 2009, 96(4), 496–499.
- Pieters, C. M. et al., The Moon mineralogy mapper (M3) on Chandrayaan-1. Curr. Sci., 2009, 96(4), 500–505.
- Mall, U. et al., Near Infrared Spectrometer SIR-2 on Chandrayaan1. Curr. Sci., 2009, 96(4), 506–511.
- Pieters, C. M. et al., Character and spatial distribution of OH/H2O on the surface of the Moon seen by M3 on Chandrayaan-1. Science, 2009, 326, 568–572.
- Clark, R. N., Detection of adsorbed water and hydroxyl on the Moon. Science, 2009, 326, 562–564.
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- Klima, R. et al., Remote detection of magmatic water in Bullialdus Crater on the Moon. Nature Geosci., 2013, 6, 737–741.
- Bhattacharya, S. et al., Endogenic water on the Moon associated with non-mare silicic volcanism: implications for hydrated lunar interior. Curr. Sci., 2013, 105, 685–691.
- Bhattacharya, S. et al., Detection of hydroxyl-bearing exposures of possible magmatic origin on the central peak of crater Theophilus using Chandrayaan-1 Moon Mineralogy Mapper (M3) data. Icarus, 2015, 260, 167–173.
- Li, S. et al., Water on the surface of the Moon as seen by the Moon Mineralogy Mapper: distribution, abundance and origins. Sci. Adv., 2017, 3, e1701471.
- Milliken, R. E. and Li, S., Remote detection of widespread indigenous water in lunarpyroclastic deposits. Nature Geosci., 2017, 10, 561–565.
- Orbiter High Resolution Camera onboard Chandrayaan-2 Orbiter
Abstract Views :267 |
PDF Views:75
Authors
Arup Roy Chowdhury
1,
Manish Saxena
1,
Ankush Kumar
1,
S. R. Joshi
1,
Amitabh
1,
Aditya Dagar
1,
Manish Mittal
1,
Shweta Kirkire
1,
Jalshri Desai
1,
Dhrupesh Shah
1,
J. C. Karelia
1,
Anand Kumar
1,
Kailash Jha
1,
Prasanta Das
1,
H. V. Bhagat
1,
Jitendra Sharma
1,
D. N. Ghonia
1,
Meghal Desai
1,
Gaurav Bansal
1,
Ashutosh Gupta
1
Affiliations
1 Space Applications Centre, Indian Space Research Organisation, Ahmedabad 380 015, IN
1 Space Applications Centre, Indian Space Research Organisation, Ahmedabad 380 015, IN
Source
Current Science, Vol 118, No 4 (2020), Pagination: 560-565Abstract
Orbiter High Resolution Camera (OHRC) onboard Chandrayaan-2 Orbiter-craft, is a very high spatial resolution camera operating in visible panchromatic band. OHRC’s primary goal is to image the landingsite region prior to landing for characterization and finding hazard-free zones. Post landing operation of the OHRC will be for scientific studies of small-scale features on the lunar surface. OHRC makes use of the time delay integration detector to have good signal-tonoise ratio under low illumination condition and less integration time due to very high spatial resolution. Ground sampling distance (GSD) and swath of OHRC (in nadir view) are 0.25 m and 3 km respectively, from 100 km altitude. GSD is better than 0.32 m in oblique view (25° pitch angle) during landing site imaging from 100 km altitude in two stereo views in consecutive orbits. This article includes the details of the configuration, sub-systems, imaging modes, and optical, spectral and radiometric characterization performance.Keywords
Ground Sampling Distance, Orbiter High Resolution Camera, Relative Spectral Response, Square Wave Response, Time Delay Integration.- Terrain Mapping Camera-2 onboard Chandrayaan-2 Orbiter
Abstract Views :250 |
PDF Views:89
Authors
Arup Roy Chowdhury
1,
Vishnukumar D. Patel
1,
S. R. Joshi
1,
A. S. Arya
1,
Ankush Kumar
1,
Sukamal Paul
1,
Dhrupesh Shah
1,
Pradeep Soni
1,
J. C. Karelia
1,
Minal Sampat
1,
Satish Sharma
1,
Sandip Somani
1,
H. V. Bhagat
1,
Jitendra Sharma
1,
Amitabh
1,
K. Suresh
1,
R. P. Rajasekhar
1,
B. B. Bokarwadia
1,
Mukesh Kumar
1,
D. N. Ghonia
1
Affiliations
1 Space Applications Centre, Indian Space Research Organisation, Ahmedabad 380 015, IN
1 Space Applications Centre, Indian Space Research Organisation, Ahmedabad 380 015, IN
Source
Current Science, Vol 118, No 4 (2020), Pagination: 566-572Abstract
The paper presents the design and development of Terrain Mapping Camera-2 (TMC-2) for Chandrayaan- 2 including science objectives; system and sub-system configuration along with the realized performance of the camera; payload characterization; aspects related to data products, etc. TMC-2, onboard Chandrayaan-2 orbiter-craft is a follow-on of the Terrain Mapping Camera (TMC) onboard Chandrayaan- 1. It operates in visible panchromatic band. It comprises three identical electro-optical chains aligned for three views (–25, 0 and +25 degree) along track direction for generation of stereo images. It provides data with 5 m horizontal ground sampling distance to generate digital elevation model. TMC-2 based on the new configuration and sub-system designs has reduction in mass and power by more than 40% compared to TMC, without compromising the performance.Keywords
Digital Elevation Model, Light Transfer Characteristics, Relative Spectral Response, Signal-to-noise Ratio, Stereo Imaging, Square Wave Response, Terrain Mapping Camera-2.References
- Kiran Kumar, A. S. and Chowdhury, A. R., Terrain mapping camera for Chandrayaan-1. J. Earth Syst. Sci., 2005, 114(6), 717–720.
- Kiran Kumar, A. S. et al., Terrain mapping camera: a stereoscopic high-resolution instrument on Chandrayaan-1. Curr. Sci., 2009, 96, 492–495.
- Kiran Kumar, A. S. et al., The terrain mapping camera on Chandrayaan-1 and initial results. In 40th Lunar and Planetary Science Conference, Houston Texas, 2009, Abstract #1584.
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- Arya, A. S., Rajasekhar, R. P., Amitabh, Gopala Krishna, B., Ajai and Kiran Kumar, A. S., Morphometric, rheological and compositional analysis of an effusive lunar dome using high resolution remote sensing data sets: a case study from Marius hills region. Adv. Space Res., 2014, 54, 2073–2086.
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- Strain/Stress Evaluation of Dorsa Geikie using Chandrayaan-2 Terrain Mapping Camera-2 and Other Data
Abstract Views :232 |
PDF Views:74
Authors
A. S. Arya
1,
Joyita Thapa
2,
Abhik Kundu
2,
Rwiti Basu
2,
Amitabh
1,
Ankush Kumar
1,
Arup Roychowdhury
1
Affiliations
1 Space Applications Centre, Jodhpur Tekra, Ambawadi Vistar, Ahmedabad 380 015, India, IN
2 Department of Geology, Asutosh College, 92, S.P. Mukherjee Road, Kolkata 700 026, India, IN
1 Space Applications Centre, Jodhpur Tekra, Ambawadi Vistar, Ahmedabad 380 015, India, IN
2 Department of Geology, Asutosh College, 92, S.P. Mukherjee Road, Kolkata 700 026, India, IN
Source
Current Science, Vol 121, No 1 (2021), Pagination: 94-102Abstract
The high-resolution panchromatic stereo camera Terrain Mapping Camera-2 (TMC-2) on-board the Indian Chandrayaan-2 mission sends images of the lunar surface at 5m resolution with a low to high sun-angle from an altitude of 100km. These images help identify subtle topographic variations and enable mapping of low-elevation landforms, one of which is a prominent ~220km long wrinkle ridge called the Dorsa Geikie (DG) lying within Mare Fecunditatis. The favourable resolutionof TMC-2 images and the digital elevation models provide opportunities for a detailed structural study of the DG and to reveal crustal shortening, cumulative contractional strain andpalaeostress regime responsible for thrust faulting for the first time.The time of deformation and formation of dorsa is also estimated for a holistic spatio-temporal understanding of deformation. This study presents initial analysis of the data received from TMC-2, and the accuracy of the results are likely to improve as the ingredients get amended and evolved in futureKeywords
Displacement-Length Scaling, Lunar Contraction, Mare Fecunditatis, Stress/Strain Evaluation, Wrinkle Ridges.References
- Chowdhury, A. R. et al., Terrain mapping camera-2 onboard Chandrayaan-2 orbiter. Curr. Sci., 2020, 118(4), 566.
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Abstract Views :217 |
PDF Views:83
Authors
Prakash Chauhan
1,
Mamta Chauhan
1,
Prabhakar A. Verma
1,
Supriya Sharma
1,
Satadru Bhattacharya
2,
Aditya Kumar Dagar
3,
Amitabh
3,
Abhishek N. Patil
3,
Ajay Kumar Parashar
3,
Ankush Kumar
3,
Nilesh Desai
3,
Ritu Karidhal
4,
A. S. Kiran Kumar
5
Affiliations
1 Indian Institute of Remote Sensing, Indian Space Research Organization, Dehradun 248 001, IN
2 Space Applications Centre, Indian Space Research Organisation (ISRO), Ahmedabad 380 015, IN
3 Space Applications Centre, Indian Space Research Organisation (ISRO), Ahmedabad 380 015, India, IN
4 U.R. Rao Satellite Centre, ISRO, Bengaluru 560 017, India, IN
5 Indian Space Research Organisation Head Quarters, Bengaluru 560 094, India, IN
1 Indian Institute of Remote Sensing, Indian Space Research Organization, Dehradun 248 001, IN
2 Space Applications Centre, Indian Space Research Organisation (ISRO), Ahmedabad 380 015, IN
3 Space Applications Centre, Indian Space Research Organisation (ISRO), Ahmedabad 380 015, India, IN
4 U.R. Rao Satellite Centre, ISRO, Bengaluru 560 017, India, IN
5 Indian Space Research Organisation Head Quarters, Bengaluru 560 094, India, IN
Source
Current Science, Vol 121, No 3 (2021), Pagination: 391-401Abstract
Imaging Infrared Spectrometer (IIRS) on-board Chandrayaan-2 is designed to measure lunar reflected and emitted solar radiation in 0.8–5.0 μmm spectral range. Its high spatial resolution (~80 m) and extended spectral range is most suitable to completely characterize lunar hydration (2.8–3.5 μmm region) attributed to the presence of OH and/or H2O. Here we present initial results from IIRS reflectance data analysed to unambiguously detect and quantify lunar 3 μmm absorption feature. After pre-processing and data-reduction, a physics based thermal correction analysis of IIRS reflectance spectra has been done using co-located temperature measurements. Hydration absorption was observed at all latitudes and surface types with varying degrees for all pixels in the study area and its absorption depth shows distinct variability associated with mineralogy, surface temperature and latitude.Keywords
Imaging Infrared Spectrometer, Lunar Hydration, Moon, Reflectance Data, Thermal Correction.References
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