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- Aasif Younus
- Ekambir Sidhu
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- Gagandeep Singh Mavi
- Alok Ranjan
- Aishwarya Sahu
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- Dev Kumar
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Journals
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Kumar, Akshay
- Antioxidant and Anti-Alzheimer Activity of Celastrus paniculatus Seed
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Authors
Affiliations
1 Vitalife Laboratories Ltd, Gurgaon, Haryana-(122001), IN
2 Department of Zoology, Bundelkhand University, Jhansi, Uttar Pradesh-(284001), IN
1 Vitalife Laboratories Ltd, Gurgaon, Haryana-(122001), IN
2 Department of Zoology, Bundelkhand University, Jhansi, Uttar Pradesh-(284001), IN
Source
International Journal of Chemistry and Chemical Engineering, Vol 3, No 1 (2013), Pagination: 29-36Abstract
The crude methanolic extract of the seeds of Celastrus paniculatus along with its organic soluble fractions were tested for their possible antioxidant and antialzheirmer (AD) activity. The extracts showed prominent DPPH free radical scavenging activity, inhibiting activity of authentic peroxynitrite (ONOO-) and inhibition of total reactive oxygen species (ROS) generation. In DPPH radical scavenging assay, the EtOAc fraction showed the highest activity with a IC50 value of 25.92±1.02 μg/ml whereas aqueous fractions had no activity at all within the tested concentration. Scavenging of the authentic ONOO- system, all extract/fractions showed good activity and among them, EtOAc fraction had the highest activity with a IC50 value of 15.79±0.18 μg/ml. EtOAc fraction also showed significant (p<0.001) inhibitory activity against the total ROS generation which was almost similar with that of the positive control Trolox (IC50 16.79±0.19 μg/ml). All extract/fractions exhibited statistically significant (p<0.001) cholinesterases (ChEs) inhibitory effects with IC50 values ranging between 134.7-227.5 μg/ml for AChE and 209.6-562.1 μg/ml for BChE.Keywords
Anti-Alzheimer, Antioxidant, Cholinesterase, Celastrus Paniculatus, ROSReferences
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- Camps P, El-Achab R, Morral J, Torrero DM, Badia A, Banos JE, Vivas NM, Barril X, Orozco M, Luque FJ. New tacrine-huperzine A hybrids (huprines): highly potent tight binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer’s disease. J Med Chem 2000; 43: 4657-66.
- Parihar MS, Hemnani T. Alzheimer’s disease pathogenesis and therapeutic interventions. J Clin Neurosci 2004; 11: 456-67.
- Enz A, Amstutz R, Boddeke H, Gmelin G, Malonowski J. Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer’s disease. Prog Brain Res 1993; 98: 431-45.
- Torreilles F, Salman-Tabcheh S, Guerin M, Torreilles J. Neurodegenerative disorders: the role of peroxynitrite. Brain Res Rev 1999; 30: 153-63.
- Butterfield DA, Reed T, Newman SF, Sultana R. Roles of amyloid β-peptideassociated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment. Free Rad Bio Med 2007; 43: 658-77.
- Markesbery WR. Oxidative stress hypothesis in Alzheimer's disease. Free Rad Bio Med 1997; 23: 134-47.
- Butterfield DA, Drake J, Pocernich C, Castegna A. Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide. Trends Mol Med 2001; 7: 548-54.
- Tran MH, Yamada K, Nakajima A, Mizuno M, He J, Kamei H, Nabeshima T. Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid β-peptide-induced cholinergic dysfunction. Mol Psyc 2003; 8: 407-12.
- Gaitonde BB, Raiker KP, Shroff FN, Patel JR.Pharmacological studies with Malkangunin indigenous tranquilizing drug. Curr Med Prac 1957; 1: 619-21.
- Ahmad R, Khan RA, Rasheed S. Preliminary screening of methanolic extract of Celastrus paniculatus and Tecomella undulate for analgesic and antiinflammatory activities. J Ethnopharm 1994; 42: 193-8.
- Karanth KS, Padma TK, Gunasundari MN. Influence of Celastrus oil on learning and memory. Arogya 1981; 7: 83-6.
- Hakim RA. A trial report on Malkanguni oil with other indigenous drugs in the treatment of psychiatric cases. Gujarat State Branch of Med Bul 1964; 77-8.
- Nalini K, Aroor AR, Kumar RA. Studies on biogenic amines and their metabolites in mentally retarded children on Celastrus oil therapy. Alter Med 1986; 1: 355-60.
- Nalini K, Karanth KS, Rao A, Aroor AR. Effects of Celastrus paniculatus on passive avoidance performance and biogenic amine turnover in albino rats. J Ethnopharm 1995; 17: 101-8.
- Gattu M, Boss KL, Alvin V, Terry JR, Buccafusco J. Reversal of scopolamine induced deficits in navigational memory performance by the seed oil of Celastrus paniculatus. Pharm Biochem Behavior 1997; 57: 793-9.
- Russo A, Izzo A, Cardile V, Borelli F, Vanella A. Indian medicinal plants as antiradicals and DNA cleavage protectors. Phytomedicine 2001; 8: 125-32.
- Braca A, Tommasi ND, Bari LD, Pizza C, Politi M, Morelli I. Antioxidant principles from Bauhinia terapotensis. J Nat Prod 2001; 64: 892-5.
- Horse-Shoe ShapedStacked Microstrip Patch Antenna for WLAN, WiMAX and IMT Applications
Abstract Views :111 |
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Authors
Affiliations
1 Department of Electronics and Communication Engineering, Punjabi University, Patiala, IN
1 Department of Electronics and Communication Engineering, Punjabi University, Patiala, IN
Source
Research Cell: An International Journal of Engineering Sciences, Vol 17, No 1 (2016), Pagination: 525-531Abstract
This paper illustrates the design and performance analysis of proposed stacked horse-shoe shaped micro strip patch antenna. In the proposed stacked antenna design, a rigid substrate having thickness 1.57mm and flexible substrate having thickness 0.2mm has been stacked. In the proposed antenna design, there are total two layers of substrates, where the flexible substrate has been placed on the upper surface of rigid substrate. The rigid and flexible substrates employed in the proposed antenna design are of duroid material having dielectric constant of 2.2. In the proposed antenna design, the rigid substrate has ahorse-shoe shaped patch on the upper surface and a ground on the bottom surface. The performance of the proposed antenna design has been analysed in terms of resonant frequency, impedance bandwidth, VSWR, impedance, return loss, gain and directivity. The proposed antenna design has resonant frequencies at 2.18 GHz and 5.2 GHz having return loss of -22.496dBand -55.012dB, respectively. The proposed design has two operating bands having operating frequency range of 2.02GHz-2.43GHz and 3.22GHz-6.13GHz. The proposed antenna has been designed and simulated using CST microwave studio 2014. The proposed antenna design can be used for WLAN, WiMAX and IMT applications.Keywords
Dual Band, Duroid, Horse-Shoe, Stacking.- Investigation of Reinforcement Content, Load and Sliding Speed on the Tribological behaviour of Copper based Silicon Carbide Composite using Design of Experiments
Abstract Views :172 |
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Authors
Affiliations
1 Department of Mechanical Engineering, Maulana Azad National Institute of Technology, Bhopal - 462003, Madhya Pradesh, IN
1 Department of Mechanical Engineering, Maulana Azad National Institute of Technology, Bhopal - 462003, Madhya Pradesh, IN
Source
Indian Journal of Science and Technology, Vol 9, No 45 (2016), Pagination:Abstract
Objectives: In this paper, the effect of reinforcement content, load and speed on the wear behaviour of Cu/SiC metal matrix composite are investigated using design of experiment. Methods: A statistical model is proposed to find the significant factor which affects the wear resistance properties of the prepared composite material. Three samples of composites were fabricated using different SiC content by stir casting. The wear behaviour of composites was evaluated for a variety of load and sliding speed at ambient temperature. Findings: It is found with the increase in SiC content the rate of wear of the composite decrease while with increase in load the wear rate increased. Also with increase of sliding speed wear rate is increased. Among the three variable parameters chosen for the study viz. reinforcement content, load and sliding speed, the load is the mainly prominent factor that affects the wear resistance of the composite. Applications/Improvements: This study can be enhanced further by using different reinforcement’s combinations and parameters. Also the wear tests can be performed at elevated temperatures.Keywords
DOE, Metal Matrix Composites, Wear.- Poisoning with an Uncommon pesticide
Abstract Views :378 |
PDF Views:1
Authors
Affiliations
1 Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, IN
1 Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 23, No 3 (2016), Pagination: 294-296Abstract
Amitraz is a veterinary pesticide commonly used for killing lice in dogs and cattle. Amitraz poisoning is reported from some areas of the world. It is important to recognise this particular poisoning and differentiate it from organophosphate poisoning (OPC). We present here a case of a 19-year-old girl who presented to us with all the typical symptoms of Amitraz poisoning and was effectively managed at our centre.Keywords
Amitraz Poisoning, Organophosphate.References
- Elinav E, Shapira Y, Ofran Y, Hassin T, Ben-Dov IZ. Near fatal Amitraz Intoxication: The Overlooked Pesticide. Pharmacology and Toxicology 2005,97,185-87
- Aydin K, Per H, Kurtoglu S etal. Amitraz poisoning in children. Eur J of Paediatrics 2002, 161: 349-50
- Varma PVC, Bhatt S, Bhat RY. Amitraz Poisoning. Indian J of Paediatrics 2013 80(4) 349-50
- Dhooria S, Behera D, Agarwal Ritesh. Amitraz: a mimicker of organophosphate poisoning. BMJ Case Rep 2015
- Ertekin V, Alp H, Selimoglu MA, Karacan M. Amitraz poisoning in children: Retrospective analysis of 21 cases. The Journal of International Medical Research 2002;30:203-5
- Yilmaz HL, Yildizdas DR. Amitraz poisoning, an emerging problem: epidemiology, clinical features, management and preventive strategies. Arch Dis Child 2003; 88: 130-134 7. Chakraborty J, Nagri SK, Gupta AN, Bansal A. An uncommon but lethal poisoning- Amitraz. Australasian Medical Journal 2011,4,8, 439-441
- Eizadi-Mood N., Sabzghabaee AM, Gheshlaghi F., Yaraghi A. Amitraz Poisoning Treatment : Still Supportive?. Iranian J of Pharma Res 2011, 10(1):155-158
- Jorens PG, Zandijk E, Belmans L etal. An unusual poisoning with the unusual pesticide amitraz. Hum Exp Toxicol 1997;16: 600-1
- Jones RD.Xylene/Amitraz: a pharmacologic review and profile. Vet Hum Toxicol 1990;32:446-8
- Hu Sung Yuan, Hsu Chia-Lung, Tsan Yu-Tse. Torsade de pointes in Amitraz poisoning. Resuscitation 81, 2010: 366-7
- Analysis of Engine Mounting Bracket for an Automobile using FEA
Abstract Views :209 |
PDF Views:0
Authors
Affiliations
1 Department of Mechanical Engineering, Chandigarh University, Gharuan - 140413, Punjab, IN
1 Department of Mechanical Engineering, Chandigarh University, Gharuan - 140413, Punjab, IN
Source
Indian Journal of Science and Technology, Vol 11, No 28 (2018), Pagination: 1-7Abstract
Objectives: The study is conducted to perform the modelling and structural analysis of engine mounting bracket and also examine the vibration isolation using FFT analyzer. Methods/ Statistical analysis: Modelling and analysis of the engine mounting bracket is carried out using solid works software. Static and modal analysis are performed to check the stress, deflection and effect of natural frequencies under loading conditions. The experimentation is also performed using FFT analyzer to check the effect of vibrations on the bracket in horizontal and vertical position. Findings: Analysis was carried out for different materials like natural rubber, neoprene, and silicon rubber. On comparing the results, the silicon rubber found better material as compare to other materials due to its low stress and deflection value and better frequency values. The experiment results shown that in the horizontal position the vibration were less than the vertical position. Application/ Improvements: Silicon rubber is considered better material for engine mounting bracket for vibration damping. This approach also helps us to find out the weak area in early design phase.References
- Roy PR, Hariram V, Subramanian M. Fatigue life prediction of a commercial vehicle radiator under internal pressure cycling loading. Indian Journal of Science and Technology. 2016; 9(33):1–6. https://doi.org/10.17485/ijst/2016/v9i33/98483
- Ragul G, Kalivarathan G, Jayakumar V, Maruthur P, Jacob, Kumar SN. An analytical investigation on design and structural analysis of cam shaft using solid works and ansys in automobiles. Indian Journal of Science and Technology. 2016; 9(36):1–9. https://doi.org/10.17485/ijst/2016/v9i36/100817
- Shi Q, Wang T, Li H. Harmonic response analysis and research of bus body based on the modal shapes. International Journal of Vehicle Noise and Vibration. 2011; 7(3):253–70. https://doi.org/10.1504/IJVNV.2011.042423
- Kalaivani R, Sudhagar K, Lakshmi P. Neural network based vibration control for vehicle active suspension system. Indian Journal of Science and Technology. 2016; 9(1):1–8. https://doi.org/10.17485/ijst/2016/v9i1/83806
- Bhat PH, Sarawade SS, Gawande SH. Numerical and experimental analysis of compressor mounting bracket in automobiles. International Review of Mechanical Engineering (IREME). 2018; 12(1):60–9. https://doi.org/10.15866/ireme.v12i1.13270
- Amin AZM, Ahmad S, Hoe YS. Electromagnetic car suspension system. Indian Journal of Science and Technology. 2016; 9(40):1–6.
- Tang Z, Pillay P, Omekanda AM, Chen Li, Cetinkaya C. Measurement of Young’s modulus for switched reluctance motor vibration determination. Proceedings of the IEEE International Electric Machines and Drives Conference. 2003; 3:1590–5. PMid:12874693
- Rejab MNA, Shukor SAA, Sofian MRM, Inayat-Hussain JI, Nazirah A, Asyraf I. Evaluation of the effectiveness of elastomeric mount using vibration power flow and transmissibility methods. Proceedings of the ICADME; 2017. p. 1–9. https://doi.org/10.1088/1742-6596/908/1/012034
- Maski S, Basavaraj Y. Finite element analysis of engine mounting bracket by considering pretension effect and service load. International Journal of Research in Engineering and Technology. 2015, 41(8).
- Dl TS, Korade DK, Darade PD, Jagtap KR. Design development and testing of hydraulic engine mount isolation in agricultural applications. IOSR Journal of Mechanical and Civil Engineering. 2016; 13(1):35–42.
- A Short Review on the Formulation of Transdermal Dermal Drug Delivery System (TDDS)
Abstract Views :439 |
PDF Views:0
Authors
Alok Ranjan
1,
Aishwarya Sahu
1,
Akansha Yadav
1,
Alka Payasi
1,
Akash Jaiswal
1,
Akshay Kumar
1,
Akash Sahu
1,
Ashwani Jangde
1,
Chandrashekhar Nayak
1,
Dev Kumar
1,
Harshita Yarda
1,
Mitali Sahu
1,
Nokesh Sahu
1,
Rajesh Patel
1,
Nisha Nair
1,
Mukta Agrawal
1,
Ajazuddin
1,
D. K. Tripathi
1,
Amit Alexander
1
Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, IN
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 10, No 2 (2018), Pagination: 90-94Abstract
The transdermal drug delivery systems (TDDS) are drug delivery system that gives rapid, the immediate therapeutic effect of the drug across the patient’s skin and its different layers. They are also called as patches. More than 75% of the drugs, now a day’s, are taken orally and are not very much effective. To overcome these problems, the transdermal drug delivery system has been evolved. The advantage of transdermal patches is that they deliver the drugs for better systemic effects at a controlled and a predetermined rate. This drug delivery system also endorses the controlled release of drug medicament into the skin of the patients. The chief aim of this drug delivery system is to deliver the drug contents into the systemic circulation through the permeation of skin at a predetermined rate. This article is an overview of different types of transdermal patches, their various method of preparation as well as their various physicochemical evaluation methods. The present study is performed for the motivation of the graduates towards publication and research. Hence, we have encouraged the graduates to prepare an informative article on the present subject.Keywords
TDDS, Systemic Circulation, Transdermal Patches, Systemic Effects, Drug Medicament, Novel Drug Delivery System.References
- Latheeshjlal.L, Transdermal Drug Delivery Systems: An Overview, International Journal of PharmTech Research. 2011, 3(4) :2140-2148.
- Hafeez, A Recent Advances in Transdermal Drug Delivery System (TDDS): An Overview, Journal of Scientific and Innovative Research. 2013; 2(3): 733-744.
- Kumar, J. A. Transdermal Drug Delivery System: An Overview, International Journal of Pharmaceutical Sciences Review and Research. 2010; 3(2): 748-765.
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- Premjeet, S. Transdermal Drug Delivery System (Patches), Applications in Present Scenario, International Journal of Research in Pharmacy and Chemistry, IJRPC. 2011; 1(4).
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- Sharma, N. A Review: Transdermal Drug Delivery System: A Tool For Novel Drug Delivery System, International Journal of Drug Development & Research, 2011; 3(3).
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