Informatics Publishing Limited

K. Mittal ¹, T. Dhingra ¹, A. Upadhyay ¹, R. Mashru ², J. Malik ³, A. Thakkar ¹

Affiliations
1 ISF College of Pharmacy, Ferozepur Road, Ghal Kalan, Moga, 142 001 Punjab, IN
2 Pharmacy Department, G.H. Patel Building, The Maharaja Sayajirao University of Baroda, Vadodara, 390002, IN
3 University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, IN

Abstract

Analytical results play a vital role in quality control of bulk drugs and pharmaceutical formulations. The main aim of this proposed research work is to study uncertainty estimation for quantitative determination of Galantamine hydrobromide from pharmaceutical formulation using ultraviolet spectrophotometry. The estimation of uncertainty was performed using cause effect (Ishikawa) diagram. Determination of uncertainty components proved to be a good way for experimental model to obtain low contribution of uncertainty to analytical results. This research paper explains identification of uncertainty sources, starting from a clear declaration of measured species, quantification of these uncertainty sources and a combination of these individual sources to estimate standard and expanded uncertainty. Determination of various components of uncertainty is a best method to confirm that results obtained of analytical methods are certain. It is concluded from the present study that uncertainty estimation for assay of Galantamine hydrobromide from pharmaceutical formulation is influenced by sample concentration rather than volumetric flask and sample mass. Thus sample concentration is the major factor to achieve precise results of the analysis.

Keywords

Galantamine Hydrobromide GH), Uncertainty Estimation, Cause Effect (Ishikawa) Diagram, Ultraviolet Spectrophotometry.

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M. M. Prakash ¹, R. Yodha ², V. K. Sharma ³, A. K. Sharma ⁴, A. Thakkar ⁵

Affiliations
1 Department of Zoology, Government Holkar Science College, Indore-452 017, M.P., IN
2 Department of Zoology, Government College, Barwaha, M.P., IN
3 Department of Zoology, P.M.B. Gujarati Science College, Indore-452 001, M.P., IN
4 Government Sanskrit College, Indore-452 017, M.P., IN
5 Department of Chemistry, P.M.B. Gujarati Science College, Indore-452 001, M.P., IN

Abstract

The effluent discharged from distillery industries has shown higher values of physico-chemical parameters in the study area. The values of temperature, pH, TS, TDS, TSS, DO, BOD, COD, chloride and potassium were found to be increased in the River Narmada at the study point II to VI in comparison to the study point I taken as control. This showed that the entry of distillery effluents altered limnochemistry of River Narmada in the study area, which may put an adverse effect on the aquatic life.

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