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- S. B. Gaikwad
- R. L. Bakal
- A. B. Roge
- R. S. Sakhare
- S. G. Shep
- D. R. Mundhada
- S. K. Bais
- D. W. Wargantiwar
- S. M. Charjan
- B. Roge Ashish
- S. Sakhare Ram
- M. A. Channawar
- B. V. Bakde
- S. R. Gawande
- M. N. Dahake
- P. P. Wattamwar
- R. A. Bongirwar
- D. S. Mohale
- S. R. Sapkal
- S. B. Jaiswal
- A. M. Pathan
- N. I. Kochar
- A. P. Devani
- A. D. Dewani
- M. D. Kshirsagar
- Rakhee K. Kotecha
- Anand S. Surana
- P. D. Nakhat
- N. P. Jogad
- M. B. Mundlik
- C. K. Gadewar
- N. A. Chandekar
- N. M. Mahajan
- P. D. Telgote
- R. A. Hajare
- R. M. Gaurkhede
- P. P. Chinchole
- A. S. Wandhare
- S. S. Karki
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Chandewar, A. V.
- Ursodeoxycholic Acid as a Biliary Agent Used in the Treatment of Liver Disease: An Overview
Abstract Views :215 |
PDF Views:1
Authors
Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal - 445001, IN
1 P. Wadhwani College of Pharmacy, Yavatmal - 445001, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 6 (2010), Pagination: 355-362Abstract
Ursodeoxycholic acid is a dihydroxy bile acid with a rapidly expanding spectrum of usage in acute and chronic liver diseases. The various mechanisms of action of this hydrophilic bile acid include direct cytoprotection, detergent action on dysfunctional microtubules, immunomodulation and induction of hypercholeresis.Its efficacy in primary biliary cirrhosis and primary sclerosing cholangitis as an adjunct to medical therapy has been well established. Newer indications include its use in the management of chronic hepatitis, cirrhosis, post liver transplant rejection, graft versus-host disease and acute viral hepatitis, where it not only relieves symptoms of holestasis but also arrests ongoing hepatocyte necrosis.
Keywords
Biliary Cirrhosis, Primary Sclerosing Cholangitis, Ursodeoxycholic Acid.
References
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- Medisafe newz eland medicines and medical devices safty authority a business unit of ministry of health.
- Evaluation Study of In-Situ Gel Using Catanionic Surfactant Mixtures
Abstract Views :208 |
PDF Views:2
Authors
Affiliations
1 P. Wadhawani College of Pharmacy, Yeotmal, IN
1 P. Wadhawani College of Pharmacy, Yeotmal, IN
Source
Research Journal of Science and Technology, Vol 8, No 4 (2016), Pagination: 165-178Abstract
The present study described the gelation temperature, gelation time, viscosity study, pH, properties of thermosensitive gel prepared of poloxamer 407 and carbopol 934P which are not affected by the concentration of each component. i.e. addition of Drugs or reference catanionic mixture. The use of Catanionic drug-surfactant mixtures was proven to be an efficient novel method of obtaining sustained drug release from Insitu gels. The effects of changes in the pH and ionic strength on the catanionic aggregates was also investigated, and this method of sustaining the release was found to be quite resilient to variations in both. Although the phase behavior was somewhat affected, large micelles and vesicles were still readily found. The drug release was significantly sustained even under NaCl. Comparing the diffusion coefficients for drugs being released from gels with those for drugs from catanionic mixtures in gels revealed differences in the order of magnitude of 10 to 100. This means that the release of a drug can be extended over time, for example, from 30 minutes to 12 hours, potentially improving both the efficiency of the formulation and the patient compliance.Keywords
Catanionic Drug-surfactant Mixtures, Gelation Temperature, Gelation Time, Viscosity Study, Poloxamer 407, Carbopol 934P.- Comparative Evaluation of Heavy Metals in Marketed Haematinic Herbal Formulations by Atomic Absorption Spectroscopy
Abstract Views :216 |
PDF Views:2
Authors
Affiliations
1 PRIST University, Thanjavur, Tamilnadu, IN
2 P. Wadhwani College of Pharmacy, Yavatmal-445 001, IN
1 PRIST University, Thanjavur, Tamilnadu, IN
2 P. Wadhwani College of Pharmacy, Yavatmal-445 001, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 4, No 1 (2014), Pagination: 11-16Abstract
In order to ascertain accumulation of heavy metals including, Arsenic, Cadmium and Lead in marketed Haematinic formulations Yavatmal City (India), investigations were performed by using atomic absorption spectrometry. The results showed heavy metals accumulation in herbal medicines procured from local market. The main purpose of the investigation was to document evidence for the users, and practitioners of marketed Haematinic formulations. WHO, (1998) mentions maximum permissible limits in raw materials only for arsenic, cadmium, and lead, which amount to 1.0, 0.3, and 10 ppm respectively. It was found that the Arsenic content was within the permissible limits given by W.H.O. The Cadmium content in HT1 (0.93 ppm), HT3 (0.56 ppm), HT4 (0.75 ppm), HT8 (1.2 ppm), HT9 (0.9 ppm), and H10 (0.7 ppm) which are above the permissible limits. The lead content in HT1,(12.7 ppm),HT2 (11.7ppm ), HT3 (12.9 ppm),HT6 (15.5 ppm),HT9 and (15.9 ppm) which are above the permissible limits. Such formulations are injurious to health of patient if consumed regularly.Keywords
Haematinic Herbal Formulations, AAS, Metal Content, Cadmium, Lead.- An Overview on In-Situ Gel
Abstract Views :235 |
PDF Views:1
Authors
Affiliations
1 P. Wadhwani College of Pharmacy, Yeotmal, IN
1 P. Wadhwani College of Pharmacy, Yeotmal, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 4 (2015), Pagination: 261-265Abstract
In-Situ Gel Delivery System In situ gelation is a process of gel formation at the site of action after the formulation has been applied at the site. Insitu gel phenomenon based upon liquid solution of drug formulation and converted into semi-solid mucoadhesive key depot. It permits the drug must be delivered in a liquid form or solution form.Keywords
In-Situ Gel, Mucoadhesive, Depot.- An Overview on Cationic Surfactant
Abstract Views :186 |
PDF Views:1
Authors
Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal, IN
1 P. Wadhwani College of Pharmacy, Yavatmal, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 4 (2015), Pagination: 294-300Abstract
Surfactants are compounds that lower the surface tension (or interfacial tension) between two liquids or between a liquid and a solid. Cationic surfactants are basically soaps or detergents, in which the hydrophilic, or waterloving, end contains a positively-charged ion, or cation. Typical examples are trimethylalkylammonium chlorides, and the chlorides or bromides of benzalkonium and alkylpyridinium ions. All are examples of quats, so named because they all contain a quaternary ammonium ion.Keywords
Surfactants, Surface Tension, Cationic Surfactants, Quaternary Ammonium Ion.- Ethosomes:Novel Approach in Transdermal Drug Delivery System
Abstract Views :223 |
PDF Views:0
Authors
B. Roge Ashish
1,
S. Sakhare Ram
1,
R. L. Bakal
1,
M. A. Channawar
1,
B. V. Bakde
1,
S. R. Gawande
1,
A. V. Chandewar
1
Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal, IN
1 P. Wadhwani College of Pharmacy, Yavatmal, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 23-27Abstract
Transdermal drug delivery system is emerging system as compaired to oral and parentral.in TDDS, patch system was developed to control the release of drug. Conventional transdermal drug delivery system achieved advantages over the oral and parenteral. Consequently a number of vesicular drug delivery systems such as liposomes, niosomes were been developed as novel transdermal drug delivery system. Firstly, it delivers the drug at a rate directed by the needs of the body, over the period of treatment. Secondly, it channel the active entity to the site of action. However, TDDS has limited market success due to the barrier properties of the Stratum Corneum and stability of formulation. ethosomes is better achievement in vesicular drug delivery system, helpful to achieve goal needed by NTDDS. Ethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and/or the systemic circulation. This review focus on introduction, mechanism of penetration, method of preparation, methods of characterization and application in the field.Keywords
TDDS, CTDDS, NTDDS, Stratum Corneum , Vesicular Drug Delivery System, Ethosomes.- A Brief Review on Gastro Retentive System
Abstract Views :333 |
PDF Views:0
Authors
M. N. Dahake
1,
P. P. Wattamwar
2,
R. A. Bongirwar
2,
D. S. Mohale
2,
R. L. Bakal
2,
A. V. Chandewar
2
Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal (M.S.), IN
2 P. Wadhwani College of Pharmacy, Yavatmal (M.S.), IN
1 P. Wadhwani College of Pharmacy, Yavatmal (M.S.), IN
2 P. Wadhwani College of Pharmacy, Yavatmal (M.S.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 28-31Abstract
Oral delivery of drug is the most preferable route of drug delivery due to ease of administration, patient compliance and flexibility in formulation etc. However, it is a well accepted fact that it is difficult to predict the real in vivo time of release with solid, oral controlled release dosage forms. Various attempts have been made to prolong the retention time of the dosage form in the stomach. One such approach is development of floating Microspheres involves preparation of a device that remains buoyant in the stomach contents due to its lower density than that of the gastric fluids.Floating microspheres are gastro-retentive drug delivery systems based on non-effervescent approach. These microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers, ideally having a size less than 200 micrometer. Floating microspheres are prepared by solvent diffusion and evaporation methods to create the hollow inner core. Floating microspheres are specially gaining attention due to their wide applicability in the targeting of drugs to stomach.Keywords
Oral Controlled Release Dosage Form, Retention Time, Floating Microsphere.- Melt In Mouth Tablet: A Review
Abstract Views :219 |
PDF Views:0
Authors
Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal, MS, IN
1 P. Wadhwani College of Pharmacy, Yavatmal, MS, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 2 (2009), Pagination: 67-70Abstract
Oral solid dosage form are more popular than other dosage form but suffer from problems like taste, solubility, bioavailability; so patient compliance. To improve patient compliance, melt in mouth tablets have emerged as an alternative to conventional oral dosage form. The aim is to provide the tablet that quickly melts upon contact with saliva and also provides a good mouthfeel.- Pellets as Controlled Release Drug Delivery System: A Review
Abstract Views :192 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, P. Wadhwani College of Pharmacy, Yavatmal (Maharashtra) 445001, IN
1 Department of Pharmaceutics, P. Wadhwani College of Pharmacy, Yavatmal (Maharashtra) 445001, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 3 (2009), Pagination: 179-183Abstract
In the recent years, considerable attention has been focused in the development of controlled release drug delivery system. The pellets have since long been used as an important formulation tool. Pelletization is an agglomeration process that converts fine powders or granules of bulk drugs and excipients into small , free flowing , spherical or semispherical units referred to as pellets. Pellets range in size typically, between 500- 1500 μm. When pellet containing the active ingredient are administered in vivo in the form of suspension capsule or disintegrating tablets, they offer significant therapeutic advantage over single unit dosage forms. An ideal controlled drug delivery system is the one which delivers the drug at a predetermined rate, locally, or systemically, for a specified period of time. Controlled release pellet formulation can be formulated by many techniques such as extrusion/spheronization, powder layering, solution/suspension layering etc.
Various applications of pellets in controlled drug delivery system formulation, recent developments, polymer and excipients used for formulation of controlled release drug delivery system are discussed in this review.
- Method Development and Validation of Ramipril and Amlodipine Besylate by RP-HPLC
Abstract Views :204 |
PDF Views:0
Authors
Affiliations
1 Department of Quality Assurance, P.W. College of Pharmacy, Dhamangaon Road, Yavatmal, 445001, IN
1 Department of Quality Assurance, P.W. College of Pharmacy, Dhamangaon Road, Yavatmal, 445001, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 12 (2011), Pagination: 1829-1832Abstract
A simple isocratic RP-HPLC method has been developed and subsequently validated for the determination of Ramipril and Amlodipine Besylate in pharmaceutical dosage forms within very short retention time. The method employs an Xterra C18 column, 5 μ, 150 mm x 4.60 mm id with flow rate of 1.5 ml/min using UV detection at 210nm. The separation was carried out using a mobile phase consisting of Sodium Lauryl Sulfate buffer by adjusting pH 2.5 and final composition is Buffer: Acetonitrile: Methanol (45:16.5:38.5)V/V. The retention time for Ramipril and Amlodipine Besylate was found to be 3.1 minutes and 3.8 minutes respectively. The results of analysis were validated statically and by recovery studies. Hence the proposed method was found to be accurate, precise, reproducible and specific and can be used for simultaneous analysis of these drugs in tablet formulation.Keywords
RP-HPLC, Sodium Lauryl Sulfate Buffer, Ramipril, Amlodipine Besylate.- Simultaneous RP-HPLC Determination of Drotaverine Hydrochloride and Mefenamic Acid in their Combined Tablet Dosage Form
Abstract Views :168 |
PDF Views:1
Authors
Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal-445001 (M.S.), IN
1 P. Wadhwani College of Pharmacy, Yavatmal-445001 (M.S.), IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 4 (2010), Pagination: 986-989Abstract
A simple, precise, accurate, rapid and reproducible reverse phase high performance liquid chromatographic procedure was developed for simultaneous determination of Drotaverine HCL and Mefenamic Acid in tablet dosage form at a single wavelength. The mobile phase used was a combination of Methanol:Acetonitrile:KH2PO4 Buffer (10 mM):(40:40:20) pH 3.5. The detection of the combined dosage form was carried out at 240 nm and flow rate was set to 1ml/min. Linearity was obtained in the concentration range of 3 to 30 μg/ml of Drotaverine HCL and 6 to 33 μg/ml of Mefenamic Acid with correlation coefficients of 0.9998 and 0.9999, respectively. The results of the analysis were validated statistically and recovery studies confirmed the accuracy of the proposed method.Keywords
Drotaverine HCL, Mefenamic Acid, RP-HPLC, Simultaneous Estimation.- Analytical Method Development for Phenylpropanolamine Hydrochloride Sustained Release Pellets
Abstract Views :172 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, P.W. College of Pharmacy, Yavatmal, Maharashtra, IN
2 Department of Pharmacology, S.K.B College of Pharmacy, Kamptee, Maharashtra, IN
3 Pharma Research, Wochardt Research Centre, Aurangabad, IN
4 Formulation and Development, Inventia Health Care Pvt. Ltd., Thane, IN
1 Department of Pharmaceutics, P.W. College of Pharmacy, Yavatmal, Maharashtra, IN
2 Department of Pharmacology, S.K.B College of Pharmacy, Kamptee, Maharashtra, IN
3 Pharma Research, Wochardt Research Centre, Aurangabad, IN
4 Formulation and Development, Inventia Health Care Pvt. Ltd., Thane, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 398-400Abstract
The main aim of the present study was to developed analytical method for phenylpropanolamine hydrochloride (PPH) in PPH sustained release pellets. Analysis of PPH i.e. assays and dissolution has been given in USP by HPLC method. No UV-Visible spectrometry method has been reported for the analysis of PPH. Analysis of PPH was carried out by using UV-Visible spectrometry after performing the part method validation of specificity (scanning the standard solution of PPH), filter paper validation and linearity. Sustained release pellets were fabricated containing PPH by solution/suspension layering technique. A solution of PPH was prepared in distilled water and UV spectrum was taken using Perkin Elmer, Lambda25-UV/Vis Spectrophotometer. Filter paper validation was done by filtering standard PPH solution (10 ppm) through Whatman filter paper No. 41 and absorbances of filtered solution was taken repetitively and compared with unfiltered solution at 205 nm. There was negligible changed in absorbance was obtained. The data for calibration plot showed good linear graph with r2=0.9980 for PPH. According to international conference on harmonization (ICH) guidelines, the present method was validated for precision, repeatability and recovery.Keywords
UV-Visible Spectrophotometer, Phenylpropanolamine Hydrochloride, Sustained Release Pellets.- RP-HPLC Method for Simultaneous Estimation of Atorvastatin Calcium Ezetimibe in Pharmaceutical Formulation
Abstract Views :147 |
PDF Views:0
Authors
M. B. Mundlik
1,
C. K. Gadewar
1,
N. A. Chandekar
1,
N. M. Mahajan
1,
P. D. Telgote
1,
A. V. Chandewar
1
Affiliations
1 Dept. of Pharmaceutical Chemistry, P. Wadhwani College of Pharmacy, Dhamangaon Road, Yavatmal-445001, IN
1 Dept. of Pharmaceutical Chemistry, P. Wadhwani College of Pharmacy, Dhamangaon Road, Yavatmal-445001, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 485-490Abstract
A simple, selective, rapid and precise reverse phase HPLC method has been developed for the simultaneous estimation of Atorvastatin calcium and Ezetimibe in pharmaceutical dosage form. A Hypersil BDS (250 mm×4.6 mm i.d 5μ) column was used for Separation. The mobile phase was Acetonitrile:water:Methanol (350:550:100, v/v) and adjust Ph to 4.0 with Orthophosphoric acid. Flow rate 2.0 ml/min with detection at 250 nm. The retention time of Atorvastatin calcium and Ezetimibe was 21.712 and 10.414 min. respectively. The developed method was validated in terms of accuracy, precision, Linearity, specificity and forced degradation, robustness, solution stability, system suitability, limit of detection. The proposed method can be used for these drugs in combined dosage forms. The proposed RP-HPLC Method for the simultaneous estimation of Atorvastatin calcium and Ezetimibe in combined dosage form is accurate, precise, linear, rugged, robust, simple, rapid and selective. It can be easily adopted for routine quality control (QC) analysis of raw materials, formulation studies. pH of the mobile phase is 4, which is good to increase the shelf life of the column.Keywords
RP-HPLC, Atorvastatin Calcium, Ezetimibe.- Synthesis, Structure and Spectral Charectarization of Friedal Craft N-Benzylation of Isatin and Their Novel Schiff’s Bases
Abstract Views :155 |
PDF Views:0
Authors
R. A. Hajare
1,
R. M. Gaurkhede
1,
P. P. Chinchole
1,
A. V. Chandewar
1,
A. S. Wandhare
1,
S. S. Karki
2
Affiliations
1 P.W. College of Pharmacy, Dhamangaon Road, Yavatmal-445001 (M.S.), IN
2 K.L.E. College of Pharmacy, Rajaji Nagar, Bangalore-560010, IN
1 P.W. College of Pharmacy, Dhamangaon Road, Yavatmal-445001 (M.S.), IN
2 K.L.E. College of Pharmacy, Rajaji Nagar, Bangalore-560010, IN