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T. Prakash , Dayanand Bhoumik , H. Shivakumar , J. S. Venkatesh , A. S. Dutta

Abstract

Objective: To evaluate the different extracts of Psidium guajava bark for its antidiarrhoeal potential against several experimental models of diarrhoea in rats. Materials and methods: Antidiarrhoeal activity of methanolic and aqueous extracts of Psidium guajava bark was studied at dose of 50 mg/kg and 100 mg/kg body weight against gastrointestinal motility, castor oil-induced diarrhoea and prostaglandin E₂-inducead enteropooling (PGE₂) in rats. Results: The methanolic and aqueous extracts of P. guajava bark showed significant antidiarrhoeal activity in a dose dependent manner against all the experimental diarrhoea models. The potent antidiarrhoeal activity may be attributed to the presence of tannin and quercetin. Conclusion: The results indicated that both the extracts of P. guajava bark at dose of 100 mg/kg were found to be more potent than the reference standard drugs, loperamid and atropine.

Keywords

, Bark

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Chiranjib Bhattacharjee ¹, Durgesh Gupta ², Lokesh Deb ³, C. Santhosh Kumar ⁴, Subal Debnath ⁴, A. S. Dutta ⁵

Affiliations
1 Sri Krupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet. Andhra Pradesh – 502277, IN
2 Rajiv Gandhi College of Pharmacy, Nautanwa, Maharajganj, UP– 27316, IN
3 I.B.S.D. Takyelpat ,Imphal, Manipur, IN
4 Sri Krupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet. Andhra Pradesh – 502277, IN
5 R. K. Pharmacy College, Kasipur, Suri – Santhiaon, Azamgarh, UP– 276001, IN

Abstract

Prunus persica Linn (L) widely distributed in Manipur, India. The leaves were used in folklore/traditional medicine to treat several inflammatory pathologies such as greenish swelling (gland), oedema etc. Reactive oxygen species as well as reactive free radicals such as hydroxyl (OH), nitric oxide (NO) etc. contribute significantly to these pathologies. In this study, antiinflammatory activity of the aqueous extracts (AEPp) of Prunus persica L leaves was evaluated on carrageenin induced oedema. The test sample at the dose of 200 mg/kg/p.o. were found to cause significant (***P<0.001) inhibition of carrageenin induced oedema. The test samples AEPp show the protection against inflammation less than standard diclofenac sodium 8mg/kg b.w. These observations established the anti-inflammatory effect of Prunus persica L leaves aqueous extract in acute inflammation.

Keywords

Prunus persica, Inflammation.

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