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Dutta, A. S.
- Antidiarrhoeal Activity of Psidium Guajava Bark Extracts
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Source
Journal of Natural Remedies, Vol 7, No 2 (2007), Pagination: 278-282Abstract
Objective: To evaluate the different extracts of Psidium guajava bark for its antidiarrhoeal potential against several experimental models of diarrhoea in rats. Materials and methods: Antidiarrhoeal activity of methanolic and aqueous extracts of Psidium guajava bark was studied at dose of 50 mg/kg and 100 mg/kg body weight against gastrointestinal motility, castor oil-induced diarrhoea and prostaglandin E2-inducead enteropooling (PGE2) in rats. Results: The methanolic and aqueous extracts of P. guajava bark showed significant antidiarrhoeal activity in a dose dependent manner against all the experimental diarrhoea models. The potent antidiarrhoeal activity may be attributed to the presence of tannin and quercetin. Conclusion: The results indicated that both the extracts of P. guajava bark at dose of 100 mg/kg were found to be more potent than the reference standard drugs, loperamid and atropine.Keywords
, Bark- Effect of leave Extract of Prunus persica Linn on Acute Inflammation in Rats
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Authors
Chiranjib Bhattacharjee
1,
Durgesh Gupta
2,
Lokesh Deb
3,
C. Santhosh Kumar
4,
Subal Debnath
4,
A. S. Dutta
5
Affiliations
1 Sri Krupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet. Andhra Pradesh – 502277, IN
2 Rajiv Gandhi College of Pharmacy, Nautanwa, Maharajganj, UP– 27316, IN
3 I.B.S.D. Takyelpat ,Imphal, Manipur, IN
4 Sri Krupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet. Andhra Pradesh – 502277, IN
5 R. K. Pharmacy College, Kasipur, Suri – Santhiaon, Azamgarh, UP– 276001, IN
1 Sri Krupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet. Andhra Pradesh – 502277, IN
2 Rajiv Gandhi College of Pharmacy, Nautanwa, Maharajganj, UP– 27316, IN
3 I.B.S.D. Takyelpat ,Imphal, Manipur, IN
4 Sri Krupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet. Andhra Pradesh – 502277, IN
5 R. K. Pharmacy College, Kasipur, Suri – Santhiaon, Azamgarh, UP– 276001, IN