Informatics Publishing Limited

L. A. Enye ¹, A. O. Ebeye ², O. A. Udi ³, A. O. Ishola ¹, P. S. Igbigbi ⁴

Affiliations
1 Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti, Ekiti State, NG
2 Department of Anatomy and Cell Biology, College of Health Sciences, Delta State University Abraka, Delta State, NG
3 Department of Anatomy, Achievers University Owo, Ondo State, NG
4 Department of Anatomy and Cell Biology, College of Health Sciences, Delta State University, Abraka, Delta State, NG

Abstract

There has been a drastic widespread use and abuse of dichlorvos (DDVP) with increasing accidental and intentional exposure. Hence, the need for a local therapeutic remedy before medical intervention. This study aimed to show the ameliorative properties of Mimosa pudica (MP) on DDVP induced neurotoxicity. 50 adult BALB/c mice were randomly divided into 5 groups of 10 mice each. Mice were given normal feed or poisoned feed (2.5% of dichlorvos in feed) with or without MP extract treatment. The exposure lasted for 28 days and all administration was done orally. At the end of exposure, mice were euthanized using chloroform and perfused transcardially using 1X PBS followed by 10% formal saline for animals designated for histochemical evaluations. Exposure to DDVP reduces granular cell layer thickness, altered Nissl substance distribution, elevates expression of GFAP and CD68 compared to control, co-administration with MP extract did not considerably reversed these effects unlike DDVP+MP that showed similar observation to control mice. GR was significantly high in all groups than the control except DDVP+MP and the level of SOD was significantly reduced in DDVP mice compared to other groups. DDVP induced hippocampal alterations accompanied by oxidative stress reversed by subsequent treatment with MP extract.

Keywords

Mimosa pudica, Oxidative Stress, Hippocampus, DDVP.

Full Text