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Santhoshi,
- Method Development and Validation of Aliskiren Hemifumarate and Valsartan in bulk drug by RP-HPLC method
Abstract Views :461 |
PDF Views:2
Authors
Somsubhra Ghosh
1,
B. Anusha
1,
Santhoshi
1,
David Banji
1,
Y. Chaithanya Kumar
1,
P. Raghavendra
1,
Subhadip Roy
2
Affiliations
1 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, 508001, IN
2 Mylan Laboratories Ltd, Hyderabad, Andhra Pradesh, IN
1 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, 508001, IN
2 Mylan Laboratories Ltd, Hyderabad, Andhra Pradesh, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 1 (2013), Pagination: 19-23Abstract
A new simple, accurate, rapid and precise isocratic High Performance Liquid Chromatographic (HPLC) method was developed and validated for the determination of Aliskiren Hemifumarate (ALSK) and Valsartan (VAL) in bulk drug. The Method employs Waters HPLC system on C8 Column (4.6 x 250 mm, 5 μm) and flow rate of 1 ml/min with a load of 10μl. The Detection was carried out at 220 nm. mobile phase used as Acetonitrile and Phosphate buffer and Methanol was used as mobile phase in the composition of 45:40:15 , phosphate buffer (0.02Mm) adjusted the pH to 4 with Orthophosphoric acid within a short runtime of 8 min. The retention times of Aliskiren (ALSK) was 3.407 min, Valsartan (VAL) was 4.268 min. The method was validated according to the regulatory guidelines with respect to specificity, precision, accuracy, linearity and robustness etc.Keywords
Aliskiren Hemifumarate, Valsartan, HPLC, Validation
References
- http://www.drugbank.ca/drugs/DB00177
- Willard HH, Merritt LL, Dean JJA, Frank AS. Instrumental Method of Analysis. CBS Publishers and Distributors, New Delhi. 1986; 9th ed: pp. 580, 626.
- Sethi PD. High-performance liquid chromatography. CBS Publishers and Distributors, New Delhi. 2001 1,1-103,.
- Kemp WL. Organic Spectroscopy. Macmillan. 1991; 3rd ed: pp. 234-267. 5. http://www.drugbank.ca/drugs/DB01258
- Tatar S, Saglik S, Comparison of UV- and Second derivative- Spectrophotometric and LC methods for the determination of Valsartan in pharmaceutical formulation, Journal of Pharmaceutical and Biomedical Analysis, 30(2); 2002: 371-375.
- Macek J., Klima J. and Ptacek P.,“Rapid determination of Valsartan in human plasma by protein precipitation and high-performance liquid chromatography”, Journal of Chromatography, 832(1); 2007: 169-172.
- Pachauri SL, Paliwal SV, Srinivas KS, Singh YG, Jain VR. Development and validation of HPLC method for analysis of some antihypertensive agents in their pharmaceutical dosage forms. Journal of Pharmaceutical sciences and Research. 2 (8); 2010: 459-464.
- Sangoi MW, Sangoi MS, Oliveira PR, Secretti LT, and Rolim CB. Determination of aliskiren in tablet dosage forms by a validated stability indicating RP-LC method. Journal of Chromatographic Science, 49(2); 2011: 170-175.
- Swamy GK , Rao JS, Kumar JR, Kumar UA, Bikshapathi DR, Kumar DV. Analytical method development and validation of aliskiren in bulk and tablet dosage form by RP-HPLC method. Journal of Pharmacy Research, 4(3); 2011: 865-867.
- Satish KB, Rao JS, and Bhargava KV. A simple and sensitive method for the determination of aliskiren hemifumarate using HPLC-UV detection. Rasayan Journal Chemistry, 4(2); 2011: 285-288.
- Satana E, Altinay S, Göger N., Özkanb S. A., Sentürk Z.,Simultaneous determination of valsartan and hydrochlorothiazide in tablets by firstderivative ultraviolet spectrophotometry and LC, J. Pharm. Biomed. Anal, 25(5-6): 1009-1013.
- Shaboury SE, Hussein SA, Mohamed NA, Mohamed MS, Spectrofluorimetric method for determination of some angiotensin II receptor antagonists, Journal of Pharmaceutical Analysis, 2(1); 2012: 12-18.
- Yadav BR, Moinuddin MD, Battu RK, Samanthula GD, Development and Validation of a New RP-HPLC Method for the Estimation of Valsartan and Hydrochlorothiazide in Tablets, Journal of Analytical Chemistry, 2(8); 2012: 13-19.
- Patnaik A, Shetty M, Sahoo S, Nayak DK, Veliyath SK, A new rp-hplc method for the determination of valsartan in bulk and its pharmaceutical formulations with it’s stability indicative studies. International Journal of Pharmaceutical Sciences, 2(3); 2011: 43-53.
- Brand Loyalty – A Study with Special Reference to Coca Cola in Rural Areas
Abstract Views :222 |
PDF Views:0
Authors
V. Vijay Anand
1,
R. Renganathan
1,
S. Balachandran
1,
L. Tony Jerry Suganth
1,
Chaitanya K. Sravanthi
1,
R. Kumarappan
1,
Santhoshi
1
Affiliations
1 School of Management, SASTRA University, Thanjavur - 613401, Tamil Nadu, IN
1 School of Management, SASTRA University, Thanjavur - 613401, Tamil Nadu, IN
Source
Indian Journal of Science and Technology, Vol 9, No 27 (2016), Pagination:Abstract
Objectives: Brand loyalty is essential to every organization to make the customers/consumers stick to the products. It helps the organization to improve the productivity and also to retain the customers. Retaining the customers with them is more important than finding the new customers. The researchers have made an attempt to study the factors influencing brand loyalty. Method/Analysis: By applying structured questionnaire, primary data were collected from 114 respondents. The statistical tools such as Chi square test, one-way ANOVA and regression analysis were administered for analysis. The study factors such as Demographic variables, Brand Awareness, Brand Image, and Perceived Quality that influences Brand loyalty. Findings: There is an association between the demographic factors viz., age, gender, marital status, family type, educational qualification. There is no association between the occupation of the respondents, since the null hypothesis is gross annual income of the respondents and preferences were accepted. The researcher found that the brand loyalty do not vary with the demographic factors namely gender, family type, gross annual income brand preferences. The brand loyalty varies with the age, marital status, educational qualification and occupation of the respondents. The results show that there is a high degree of correlation between the study variables and the brand loyalty. It is found that the predictor variables viz., Brand awareness, Brand image and perceived quality are statistically significant determinants towards Brand loyalty. Applications/Improvements: The present study focuses those important factors which are influencing brand loyalty. Based on the significance, the organization has to give much priority to retain and improve their brand loyalty.Keywords
Brand Loyalty, Brand Awareness, Brand Image, Perceived Quality.Full Text