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Bhattacharjee, Atanu
- Interactome Analysis of Devs Protein Involved in Persistence of Mycobacterium tuberculosis and Design of Inhibitor against its Interacting Persister Protein: an Approach to Inhibit Protein-protein Interaction
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PDF Views:449
Authors
Affiliations
1 Department of Biotechnology and Bioinformatics, North Eastern Hill University, Shillong-793022, IN
2 Centre for Advanced studies in Crystallography and Biophysics, University of Madras, Guindy (Maraimalai) Campus, Chennai- 600 025, IN
1 Department of Biotechnology and Bioinformatics, North Eastern Hill University, Shillong-793022, IN
2 Centre for Advanced studies in Crystallography and Biophysics, University of Madras, Guindy (Maraimalai) Campus, Chennai- 600 025, IN
Source
Indian Journal of Bioinformatics and Biotechnology, Vol 2, No 3 (2013), Pagination: 57-64Abstract
Background: Mycobacterium tuberculosis has been a potential threat for humans for ages. Its invulnerability to various drugs and persistency has emerged as a stumbling block in eradicating the pathogenecity of the bacteria. A protein-protein interaction network of redox sensor histidine kinase response regulator (devS), a member of the two- component regulatory system devR/devS is known to be involved in onset of the dormancy response acting as a redox sensor was studied. Methods: An interactome level analysis of devS with other proteins involved is essential to gain insights into the proteins involvement in persistence of tuberculosis. Folding pattern of the proteins involved in the interaction was analyzed and molecular docking was performed to understand the protein-ligand interaction. Result: DevS protein directly interacts with high confidence with transcriptional regulatory protein (devR) protein forming a two-component system, probable transcriptional regulatory (narL) protein and a universal stress protein (MT3220). Hypoxia sensor histidine kinase response regulator dosT (MT2086) interact with the two-component regulatory system devR/devS involved in dormancy and is structurally aligned with devS protein. The folding patterns of devS, MT2086 and MT0867 are similar but at a different folding rate. Conslusion: DevS is shown to interact with devR protein with high confidence, which is involved in the two-component system. A better interaction is seen with piperine, berberine and allin with all the four target proteins.Keywords
Mycobacterium tuberculosis, Persister Proteins, InteractomeReferences
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- An Application of Linear Mixed Effect Model to Compare the Drug Treatment Effect in Patients with Type 2 Diabetes
Abstract Views :375 |
PDF Views:0
Authors
Affiliations
1 Dept. of Statistics, Gauhati University
1 Dept. of Statistics, Gauhati University
Source
Indian Journal of Public Health Research & Development, Vol 4, No 1 (2013), Pagination: 24-27Abstract
In this article, different types of mixed effect models have been applied for drug effect comparison in type 2 diabetes patients. The mixed effect models have been applied through Bayesian approach and compared with frequency approach. The combination of metformin with pioglitazone is found to be effective compared to pioglitazone with gliclazide.Keywords
MCMC, FBS, AR(1)References
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- An Application of Bootstrap Regression Method in Age Dependency Structure to the Community
Abstract Views :212 |
PDF Views:3
Authors
Affiliations
1 Department of Statistics, Gauhati University, Guwahati, IN
2 Jawaharlal Nehru School of Management, Assam University, Silchar, Assam, IN
1 Department of Statistics, Gauhati University, Guwahati, IN
2 Jawaharlal Nehru School of Management, Assam University, Silchar, Assam, IN
Source
Indian Journal of Public Health Research & Development, Vol 4, No 3 (2013), Pagination: 44-48Abstract
The age dependency is an important factor to contribute to the economic structure of a family. In this work, the effect of age dependency on the economic sustainability in the families of Varanasi city has been observed. To deal with small sample size problem the boot strapping method has been used. The relevant calculations are done using the software R. It has been found that the presences of young dependent people make the families economically poor. However, the presences of old age people in the family make it economically sustainable.Keywords
Bi-Square, Huber Estimator, M-Estimator, Re-Sampling MethodReferences
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- Evaluation of Acute and Sub-Chronic Oral Toxicity Study of Ethanolic Extract of Crataeva nurvala Buch-Ham Stem Bark on Experimental Wistar Rats
Abstract Views :172 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacognosy, NGSM Institute of Pharmaceutical Sciences, Deralakatte, Mangalore – 575 018, Karnataka, IN
2 Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, Deralakatte, Mangalore – 574 018, Karnataka, IN
3 Department of Pharmacognosy, NGSM Institute of Pharmaceutical Sciences, Deralakatte, Mangalore – 574 018, IN
1 Department of Pharmacognosy, NGSM Institute of Pharmaceutical Sciences, Deralakatte, Mangalore – 575 018, Karnataka, IN
2 Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, Deralakatte, Mangalore – 574 018, Karnataka, IN
3 Department of Pharmacognosy, NGSM Institute of Pharmaceutical Sciences, Deralakatte, Mangalore – 574 018, IN