The effect of Topical Application of Extra Virgin Olive Oil on Alleviating Knee Pain in Patients with Knee Osteoarthritis: A Pilot Study
Participants: A convenient sample of thirty patients with knee(s) osteoarthritis (16 females and 14 males) were randomly assigned to three groups; Group A (n=10) treated with topical application of EVOO and exercise, group B (n=10) received topical non-steroidal anti-inflammatory drugs (Ketoprofen gel) over the knee(s) and exercise, and group C received therapeutic exercise only.
Method: Treatment was carried out in physical therapy outpatient clinic for 5 days a week for two weeks. Group A received topical EVOO (3ml) and group B received topical ketoprofen gel (3 cm2) three times a day followed by therapeutic exercise. Group C received therapeutic exercise only three times a day. Pain visual analog scale (VAS) and Western Ontario and McMaster (WOMC) universities index measurement were taken at baseline and after two weeks of treatment.
Results: All groups showed significant improvement (p0.05), however, both groups significantly experienced less pain than group C (p
Conclusion: Topical application of EVOO showed to be effective in alleviating the symptoms of patients diagnosed with knee osteoarthritis compared to topical application of NSAID.
- Robbins, L., Burckhardt CS,. Hannan MT and. DeHoratius RJ. Clinical Care in Rheumatic Diseases, 2nd Edition. Atlanta: American College of Rheumatology; 2001. p.225-230.
- Lawrence RC, Felson DT, Helmick CG, et al. National Arthritis Data Workgroup. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 2008; 58(1):26-35.
- Fontaine K, Haaz S, Heo M Projected prevalence of US adults with self-reported doctor-diagnosed arthritis, 2005 to 2050. Clin Rheumatol. 2007; 26:772–4.
- Centers for Disease Control and Prevention.State prevalence of self-reported doctor-diagnosed arthritis and arthritis-attributable activity limitation—United States, 2003. MMWR Morb Mortal Wkly Rep. 2006; 55:477–81.
- Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ. 2003; 81(9):646-56.
- Barron M, Rubin B. Managing osteoarthritic knee pain. J Am Osteopath Assoc. 2007; 107:ES21–27.
- Hsieh J, Dominick K. Use of non-pharmacological therapies among patients with osteoarthritis. Aging Clin. 2003; Exp Res 15:419–25.
- Rao JK, Mihaliak K, Kroenke K, Bradley J, Tierney WM, Weinberger M. Use of complementary therapies for arthritis among patients of rheumatologists. Ann Intern Med. 1999; 131(6):409-16.
- Lopez J, Badimon L, Bonanome A et al. Monounsaturated fat and cardiovascular risk. Nutr Rev. 2006; 64:S2–S12.
- Owen RW, Haubner R, Würtele G, Hull E, Spiegelhalder B, Bartsch H. Olives and olive oil in cancer prevention. Eur J Cancer Prev. 2004;13(4):319-26.
- Darlington L, Stone T. Antioxidants and fatty acids in the amelioration of rheumatoid arthritis and related disorders. Br J Nutr. 2001; 85:251–69.
- Beauchamp G, Keast R, Morel D et al. Photochemistry: ibuprofen-like activity in extravirgin olive oil. Nature. 2005; 437:45–6.
- Bjordal J, Ljunggren A, Klovning A, Slordal L. Non-steroidal anti-inflammatory drugs, including cyclo-oxygenase-2 inhibitors, in osteoarthritic knee pain: meta-analysis of randomized placebo controlled trials. BMJ. 2004; 329:1317–20.
- Mason L, Moore RA, Edwards JE, Derry S, McQuay HJ. Topical NSAIDs for acute pain: a meta-analysis. BMC Fam Pract. 2004; 5:10.
- Altman R, Asch E, Bloch D. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 1986; 29:1039–49.
- Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957; 16:494–502.
- Guermazi M, Poiraudeau S, Yahia M, et al. Translation, adaptation and validation of the Western Ontario and McMaster Universities osteoarthritis index (WOMAC) for an Arab population: the Sfax modified WOMAC. Osteoarthritis Cartilage. 2004; 12(6):459-68.
- Dayan N, Batheja P, Michniak, B. Oleic Acidinduced Skin Penetration Effects of a Lamellar Delivery System. Cosm and toil magz. 2007; 122;73-82.
- Petersen SG, Beyer N, Hansen M, Holm L, Aagaard P, Mackey AL, Kjaer M. Nonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients. Arch Phys Med Rehabil. 2011 Aug;92(8):1185-93.
- Esser S, Bailey A. Effects of exercise and physical activity on knee osteoarthritis. Curr Pain Headache Rep. 2011 15:423–30.
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