Indian Journal of Public Health Research & Development

Khemasili Kosala ¹, Moch. Aris Widodo ², Sanarto Santoso ³, Setyawati Soeharto ²

Affiliations
1 Doctoral Program of Medical Sciences, Brawijaya University, Malang, ID
2 Department of Pharmacology, Brawijaya University, Malang, ID
3 Department of Microbiology, Brawijaya University, Malang, ID

Abstract

Objective: To evaluate the bronchorelaxation effect of methanol extract of Coptosapelta flavescens Korth. ischolar_main (MECFR) on cholinergic, histamine receptors and beta2-adrenoceptors, in vitro.

Method: The research design was experimental in which a 4-mm long guinea pig’s bronchus was kept in an isolated organ bath containing Kreb’s-Henseleit solution at 37°C, pH 7.4 and flooded with carbogen gas. The study was divided into 3 groups: in Group 1 and 2, the bronchial rings were incubated in 3 concentrations of MECFR, and then contracted with cumulative doses of methacholine and histamine, respectively; in Group 3, the bronchial ring was incubated in 3 concentrations of propranolol, contracted with a single dose of methacholine, and then the MECFR was administered in cumulative doses.

Results: In both Group 1 and Group 2, the dose-response curves of all 3 doses of MECFR shifted to the right with lower E_max (P<0.05) as compared to the negative control. In Group 3, the dose-response curves showed MECFR has bronchorelaxation effect on bronchial rings both in the presence of propranolol andwithout, with similar E_max (P>0.05).

Conclusion: MECFR exhibits bronchorelaxation effects by acting as non-competitive antagonist at the cholinergic and histamine1 receptors, and also by acting as beta₂-adrenoceptor agonist.

Keywords

Beta₂-adrenoceptor, Cholinergicreceptor, Coptosapelta Flavescens Korth Root, Histamine Receptor.

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N.A. Moch. Sukron Prasetyo ¹, Sanarto Santoso ², Tony Suharsono ³

Affiliations
1 Student of Magister Nursing Program, University of Brawijaya, ID
2 Lecturer of Faculty of Medicine,University of Brawijaya, ID
3 Lecturer of Magister Nursing Program, University of Brawijaya, ID

Abstract

Introduction: Cardiac arrest is a condition of the cessation of blood circulation in the body. First aid cardiac arrest is cardiopulmonary resuscitation consisting of chest compression and ventilation. Chest compression is a factor that affects the return of spontaneous circulation (ROSC) patients. In addition to the depth of chest compressions, the chest compression rate is a major factor that can increase the chances of the patient’s life shortly after suffering a cardiac arrest. Aim: The purpose of this study is to determine the factors that affect the rate of the chest compressions performed by nurses as a first responder. Method: The method used in this study is analytic cross sectional correlative to 107 respondents. Chest compression rate measurement using a chest compression CPR Help Zoll’s Real product was analyzed using an application Rescue Net Code Review. Finding: Preliminary study results showed that the factors that affect the rate of the chest compression is gender, age, BMI, education, the last time attend to BLS training and the last time giving chest compressions. Based on the results of the linear regression analysis, gender is a factor that most affects to the rate of the chest compression (β = -7.8). It explains that the male responder provide a faster compression 8x/min compared with female responder. Conclusion: In conclusion, gender, the last time attends to BLS training and the last time provides chest compression significantly affect to the rate of the chest compression

Keywords

Cardiac arrest, Rate, Chest Compression

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