Indian Journal of Public Health Research & Development

Sonny T. Lisal ¹, Saidah Syamsuddin ¹, Anisa ¹

Affiliations
1 Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, ID

Abstract

The aim of the study was to find out the effect of non-computerized cognitive remediation and risperidone therapy to improve cognitive function and disability condition in schizophrenia patients. This study was an experimental research design, with fourteen participants divided into two group as the experimental group and the control group. The experimental and control groups both received Risperidone. In addition, the experimental group was given the non-computerized cognitive remediation (CR).The non-computerized cognitive remediation will be carried out in 12 sessions (3 sessions per week) using mainly paper and pencil tasks and is based on cognitive strategy instruction. Moreover, all samples will be measured for PANSS (Positive and Negative Symptom Scale), WHODAS 2.0 (World Health Organization Disability Assessment Schedule), and SCoRS Vi (Schizophrenia Cognition Rating Scales Indonesian Version) scores. As the results, both experimental and control group showed a significant decrease in the SCoRS Vi and WHODAS 2.0 score (p=0.001). However, the experimental group showed greater improvement compared to the control group. Synergistic effect of Non-computerized Cognitive Remediation and Risperidone can improve disability condition in schizophrenia patients.

Keywords

Schizophrenia, Non-Computerized Cognitive Remediation, Risperidone, Disability.

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Sonny T. Lisal ¹, Saidah Syamsuddin ¹, Balgis ¹

Affiliations
1 Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar 90245, ID

Abstract

Administration of atypicalantipsychotics (risperidone, olanzapine and clozapine) can improve cognitive dysfunction which occurs in schizophrenia patients. This study was aimed at analyzing the effect of olanzapine on the improvement of clinical symptom (the positive and negative symptoms) in schizophrenia patients. The study was observational with analytic approach on inpatient and outpatient schizophrenia patients in Wahidin Sudirohusodo Hospital and its networking. Subjects comprised of 30 samples who were divided into two groups: the risperidone group which consisted of 15 subjects and the olanzapine group which consisted of 15 subjects. The positive and the negative Symptom Scale (PANSS) wasused to evaluate the psychopathological symptoms. The results showed that improvement of clinical symptom based on the decrease of the positive symptom of thePANSS was significant (p<0.05) since the 2^nd week in both groups. However, comparison of the changes of the positive symptom of the PANSS after medical treatment showed that the decrease of the positive symptom of the PANSS was greater in the risperidone group compared to the olanzapine group (p<0,05). As for negative symptom of the PANSS between the two treatment groups showed that the decrease of negative symptom of the PANSS was significant (p<0.05) since the 2^nd week.

Keywords

Risperidone, Olanzapine, Clozapine, Positive and Negative Symptoms, Schizophrenia.

Full Text

     

Sonny T. Lisal ¹, Saidah Syamsuddin ¹, Balgis ¹

Affiliations
1 Hasanuddin University, Makassar 90245, ID

Abstract

Administration of atypical anti psychotics (risperidone, olanzapine and clozapine) can improve cognitive dysfunction which occurs in schizophrenia patients. This study was aimed at analyzing the effect of olanzapine on the improvement of clinical symptom (the positive and negative symptoms) in schizophrenia patients. The study was observational with analytic approach on inpatient and outpatient schizophrenia patients in Wahidin Sudirohusodo Hospital and its networking. Subjects comprised of 30 samples who were divided into two groups: the risperidone group which consisted of 15 subjects and the olanzapine group which consisted of 15 subjects. The positive and the negative Symptom Scale (PANSS) was used to evaluate the psychopathological symptoms. The results showed that improvement of clinical symptom based on the decrease of the positive symptom of the PANSS was significant (p<0.05) since the 2^nd week in both groups. However, comparison of the changes of the positive symptom of the PANSS after medical treatment showed that the decrease of the positive symptom of the PANSS was greater in the risperidone group compared to the olanzapine group (p<0,05). As for negative symptom of the PANSS between the two treatment groups showed that the decrease of negative symptom of the PANSS was significant (p < 0.05) since the 2^nd week.

Keywords

Risperidone, Olanzapine, Clozapine, Positive and Negative Symptoms, Schizophrenia.

Full Text