Indian Journal of Public Health Research & Development

M. Madhumitha ¹, M. Vijayakumar ², Ponnudurai Arangannal ², J. Jeevarathan ², S. Amudha ², J. Aarthi ²

Affiliations
1 Department of Pedodontics, Sree Balaji Dental College & Hospital, BIHER, Pallikarani, Chennai, IN
2 Sree Balaji Dental College & Hospital, BIHER, Pallikarani, Chennai, IN

Abstract

Dental caries is an irreversible microbial disease of the calcified tissues of teeth, which is characterized by demineralization of inorganic portion and destruction of organic substance of the tooth which often leads to cavitation. It is a multifactorial disease. Among the various microorganism Streptococcus mutans considered to be chief etiological agent. Immune therapy against this microorganism to curtail this widespread disease has gained interest. Passive antibody administration has also been examined for effects on indigenous mutans streptococci. Passive immunotherapy is of interest due to its many advantages. This review briefs on passive immunotherapy.

Keywords

Dental Caries, Immunotherapy, Streptococci.

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M. Madhumitha ¹, M. Vijayakumar ², Ponnuduraiarangannal ², J. Jeevarathan ², S. Amudha ², J. Aarthi ²

Affiliations
1 Department of Paedodontics, Sree Balaji Dental College & Hospital, BIHER, Pallikarani, Chennai, IN
2 Sree Balaji Dental College & Hospital, BIHER, Pallikarani, Chennai, IN

Abstract

Background: Dental caries is an infectious microbiologic disease of the teeth and is one of the most common diseases in humans .It is a multifactorial disease caused by interaction between four principal factors-the host (saliva and teeth), the microflora, the substrate(diet) and the time. Targeting the microbial factor of the disease, researchers have been developing vaccination to protect the caries prone children and adults. Immunization includes active and passive immunization. Vaccines should be safe and effective. This article gives an insight into the shortcomings and challenges of caries vaccinations.

Keywords

Caries Vaccination, Active Immunization, Passive Immunization.

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M. Madhumitha ¹, M. Vijayakumar ², Arangannal Ponnudurai ³, J. Jeevarathan ⁴, J. Aarthi ⁵

Affiliations
1 Post Graduate Student, Department of Paedodontics, Sree Balaji Dental College, BIHER, Pallikarani, Chennai, IN
2 Senior Lecturer, Sree Balaji Dental College, BIHER, Pallikarani, Chennai, IN
3 Professor and Head of the Department, Sree Balaji Dental College, BIHER, Pallikarani, Chennai, IN
4 Professor, Sree Balaji Dental College, BIHER, Pallikarani, Chennai, IN
5 Reader, Sree Balaji Dental College, BIHER, Pallikarani, Chennai, IN

Abstract

Background: Dental caries is an infectious microbiologic disease of the teeth and is one of the most common diseases in humans. It is a multifactorial disease caused by interaction between four principal factors-the host (saliva and teeth), the microflora, the substrate (diet) and the time. Targeting the microbial factor of the disease, researchers have been developing vaccination to protect the caries prone children and adults. Immunization includes active and passive immunization. Vaccines should be safe and effective. This article gives an insight into the shortcomings and challenges of caries vaccinations.

Keywords

Caries Vaccination, Active Immunization, Passive Immunization.

Full Text