Indian Journal of Public Health Research & Development

Laveena Dabla ¹, Sapna Bansal ², Nalin Vilochan ¹, Vaishali Syal ³, Pankaj Kumar ¹, Sheenam Wadhwa ¹, Shikha Gulia ⁴

Affiliations
1 MBBS, Junior Resident, Amity College of Nursing, Amity University Haryana, IN
2 M.D Anesthesia, Associate Professor, Amity College of Nursing, Amity University Haryana, IN
3 M.Sc. Anesthesiology and Operation Theatre Technology, Department of Anesthesiology, Maharishi Markandeshwar (Deemed to be University) Mullana, Ambala, Haryana, IN
4 M.Sc. Neurosciences Nursing, Amity College of Nursing, Amity University Haryana, IN

Abstract

Background and Aims: Aim of this study was to compare the doses of Propofol and Etomidate using Entropy Monitor and per kilogram body weight doses and hemodynamic effects of both the drugs after induction and intubation. Material and Method: Hundred patients of ASA grade I and II in the age group of 18-60, scheduled for elective surgery under general anesthesia were randomly allocated in two groups. In group A: Induction dose of Etomidate was given till Entropy reached value of 40. In group B: Induction dose of Propofol was given till Entropy reached a value of 40. The doses given in ml were noted and calculated. Hemodynamic parameters like SBP, DBP, MAP, heart rate, oxygen saturation (SpO2), end tidal carbon dioxide were noted at baseline, induction, 1 min, 2 min, 3 min, 4 min, 5 min and 10 min thereafter. Data was subjected to statistical analysis. Results: There was reduction in induction doses using Entropy guided hypnosis level. The mean dose of Etomidate according to entropy was 16.9±2.8mg (0.27mg/kg) and per kilogram body weight dose was 18.61±3.4mg (0.3mg/kg). The mean dose of Propofol according to Entropy was 108.8±17.6 mg (1.72mg/kg) and per kilogram body weight dose was 124±23.1mg (2mg/kg). Incidence of hypotension and tachycardia was more with Propofol than Etomidate Conclusion: Use of Entropy resulted in decrease in the dose of Etomidate and Propofol. Etomidate provides more hemodynamic stability than Propofol after induction and intubation.

Keywords

Entropy monitor, hypnotic doses, hemodynamic response, Propofol, Etomidate.

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Sapna Bansal ¹, Laveena Dabla ², K.S. Bhatia ³, Becki ², Aiysha ²

Affiliations
1 Assosciate Professor, Department of Anaesthesiology, Maharishi Markandeshwar Deemed to be University, IN
2 Post Graduate Student, Department of Anaesthesiology, Maharishi Markandeshwar Deemed to be University, IN
3 Professor, Department of Anaesthesiology, Maharishi Markandeshwar Deemed to be University, IN

Abstract

Background: Continuous efforts are being taken to provide better postoperative quality of recovery especially in female patients in terms of both physical and emotional parameters after surgery and anaesthesia. Method: The present study was carried out in 70 female patients of ASA Grade I & II between the age group of 20-50 years scheduled to undergo lower abdominal surgery. They were randomly divided into two groups of 35 patients each to receive either table t duloxetine 60 mg or gabapentin 900 mg orally 3 hours prior to surgery and repeated 24 hours later with the same dose. Results: Both the groups were comparable regarding mean age and weight of the patients (Table I). There was highly significant difference in both mean and median values of quality of recovery in both the groups with better scores in the gabapentin group. The mean opioid requirement in group A was 2.83±1.20 and in group B was 1.90±1.04 which was also highly significant, p value 0.0009. Regarding patient satisfaction 54.28% patients in gabapentin group showed excellent satisfaction as compared to 28.50% patients in duloxetine group, p value 0.057. Side effects were observed more in Group A Conclusion: Gabpentin should be considered as an effective strategy for improving the postoperative quality of recovery and reducing the post-surgical narcotic consumption and related side effects.

Keywords

Duloxetine, Gabpentin, Postoperative Pain, Quality of Recovery.

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