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Authors
Affiliations
1 Department of Pharmacognosy, Faculty of Pharmacy, MUST, Giza, EG
2 Department of Pharmacognosy, Faculty
of Pharmacy, Fayoum University, Fayoum, EG
3 Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, EG
4 Division of Pharmaceutical Industries, Department of Pharmacognosy, National Research Centre, Giza, EG
5 Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, EG
Source
Indian Journal of Public Health Research & Development, Vol 11, No 2 (2020), Pagination: 1517-1523
Abstract
Introduction: Ravenala madagascariensis (Sonn.) family Strelitziaceae, commonly called traveler’s tree or palm; it is used traditionally in India as tea made from young leaves for treatment of diabetes. On the other hand its seed found to have antiseptic properties. Objective: Phytochemical investigation and isolation as well as testing the antioxidant and antimicrobial activities of the crude total and different successive fractions. Material and Method: The leaves total ethanol extract was subjected for phytochemical screening. The n- BuOH fraction was fractionated using chromatographic isolation. Total phenolics and flavonoids and antioxidant activity of the crude total ethanol extract as well as n-hexane, CH2Cl2, EtOAc and n- BuOH successive fractions were determined using ABTS assays. On the other hand the antimicrobial of the crude total ethanol was carried out against 13 microorganisms using agar well diffusion method. Results: Phytochemical screening showed the presence of flavonoids, tannins and sterols. Three phenolic compounds were isolated from the n- BuOH fraction and they were identified using different spectroscopic techniques. The different fractions showed high antioxidant activities especially EtOAc fraction that showed 88.96% for ABTS inhibition. Crude total ethanol extract showed selective moderate antimicrobial activity against the tested strains of Cryptococcus neoformans, Bacillus cereus and Serratia marcenscens. Conclusion: The ethyl acetate fraction showed significant antioxidant activity probably due to presence of the flavonoids contents
Keywords
Antimicrobial, Antioxidant, Flavonoids, Phenolics, Ravenala
