Indian Journal of Public Health Research & Development

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Transgenic Animals and Drug Development: a Review


Affiliations
1 Dept. of Pharmacology, S.S Institute of Medical Sciences and Research Centre, Davangere 577005 Karnataka, India
2 Department of Pharmacology, M.S. Ramaiah Medical College, Bangalore, India
3 Dept. of Microbiology, Sri Devraj Urs Medical College, Karnataka, India
4 Department of Microbiology, Sri Devraj Urs Medical College, Karnataka, India
5 Dept. of Anatomy, S.S. Institute of Medical Sciences, Karnataka, India
6 Dept. of Forensic Medicine, S.S. Institute of Medical Sciences, Karnataka, India
     

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Pharmaceutical companies face the challenge that only ten percent of compounds tested in clinical trials eventually make it to the market and out of these, only a few will succeed to generate profit. Utilization of genetically altered animals (transgenic animals) in the pharmaceutical industry provides important insights into the function and interaction of particular gene products. Now, with the help of advanced technology numerous transgenic animals have been produced. The advent of transgenic animals has influenced the attrition rate in pharmaceutical research and development by increasing the quality of both targets and compounds. As with any experimental animal model, transgenic animals also have certain limitations but still they provide a powerful tool for the advancement of drugs in the pharmaceutical industry.

Keywords

Animals, Experiment, Drug
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  • Transgenic Animals and Drug Development: a Review

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Authors

Venkatesh M. Patil
Dept. of Pharmacology, S.S Institute of Medical Sciences and Research Centre, Davangere 577005 Karnataka, India
Santosh N. Kugali
Department of Pharmacology, M.S. Ramaiah Medical College, Bangalore, India
Rajeshwari Surpur
Dept. of Microbiology, Sri Devraj Urs Medical College, Karnataka, India
S. A. Dhanalaxmi
Department of Microbiology, Sri Devraj Urs Medical College, Karnataka, India
M. R. Anitha
Dept. of Anatomy, S.S. Institute of Medical Sciences, Karnataka, India
V Vijayanath
Dept. of Forensic Medicine, S.S. Institute of Medical Sciences, Karnataka, India

Abstract


Pharmaceutical companies face the challenge that only ten percent of compounds tested in clinical trials eventually make it to the market and out of these, only a few will succeed to generate profit. Utilization of genetically altered animals (transgenic animals) in the pharmaceutical industry provides important insights into the function and interaction of particular gene products. Now, with the help of advanced technology numerous transgenic animals have been produced. The advent of transgenic animals has influenced the attrition rate in pharmaceutical research and development by increasing the quality of both targets and compounds. As with any experimental animal model, transgenic animals also have certain limitations but still they provide a powerful tool for the advancement of drugs in the pharmaceutical industry.

Keywords


Animals, Experiment, Drug

References