Open Access
Subscription Access
Open Access
Subscription Access
Drug Induced Erythema Multiforme: a Case Report
Subscribe/Renew Journal
Erythema Multiforme is a rare, acute, inflammatory mucocutaneous condition caused by a hypersensitivity reaction with the appearance of cytotoxic T lymphocytes in the epithelium that induce apoptosis in keratinocytes, which leads to satellite cell necrosis. Reactions to drugs are quite common and are generally mild, hence not reported. However, occasionally life threatening reactions including Erythema multiforme major (Steven Johnson's syndrome) and Toxic Epidermal Necrolysis may occur. A wide spectrum of drugs can sometimes give rise to Erythema Multiforme. We report a case of Erythema Multiforme in a 4 year old female following administration of Non Steroidal Anti-Inflammatory Drugs.
Keywords
Erythema Multiforme, Drug Reaction, Hypersensitivity Reaction
Subscription
Login to verify subscription
User
Font Size
Information
- Crispian Scully, Jose Bagan. Oral mucosal diseases: Erythema multiforme. British Journal of Oral and Maxillofacial Surgery 2008; 46: 90-95.
- SR Isik, G Karakaya, G Erkin, AF Kalyoncu. Multidrug- Induced Erythema Multiforme. J Investig Allergol Clin Immunol 2007; Vol. 17(3): 196-198.
- Martin S. Greenberg. Ulcerative, Vesicular, and Bullous Lesions. Burkett’s Oral Medicine, Ninth edition 1994; Chapter 2 (pp 20-22): J.B. Lippincott Company, Philadelphia.
- C. Scully, J.V. Bagan. Adverse Drug Reactions in the Oro-facial Region. Crit. Rev Oral Biol med. 2004; 15(4): 221-239.
- P Sen, SH Chua. A Case of Recurrent Erythema Multiforme and its Therapeutic Complications. Ann Acad Med Singapore 2004;33:793-6.
- C Leaute-Labreze, T Lamireau, D Chawki, J Maleville, A Taieb. Diagnosis, classification, and management of erythema multiforme and Stevens-Johnson syndrome. Arch Dis Child 2000; 83: 347-352.
- LY Chan, WYM Tang, CY Leung, KK Lo, Recurrent erythema multiforme in a child. HKMJ September 2000; Vol. 6: No 3
- P. Michele Williams, Robert J. Conklin. Erythema Multiforme: a review and contrast from Stevens- Johnson syndrome/toxic epidermal necrolysis. Dent Clin N Am 49 (2005) 67-76.
- Neivell, Damm, Allen, Bouquot. Oral and Maxillofacial Pathology, Second Ed. 2008; Chapter 16: Page no. 674- 676. Saunders, An Imprint of Elsevier.
- Jordi Castellsague, Luís-Alberto García-Rodríguez, Alberto Duque and Susana Pérez. Risk of serious skin disorders among users of oral antifungals: a population-based study. BMC Dermatology 2002, 2:14.
Abstract Views: 222
PDF Views: 0