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Comparative Study of Lipid Profile in Chronic Smokers with and without Acute Myocardial Infarction
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Background
Smoking is one of the major risk factors in the genesis of coronary atherosclerosis and development of coronary heart disease. Smoking may alter normal plasma lipoprotein levels.
Objective
The present study was undertaken to compare the lipid profile between chronic smokers (Group A) and chronic smokers with myocardial infarction (Group B).
Material and Methods
Fifty apparently healthy chronic smokers and 50 smokers with myocardial infarction were selected for the study. Fasting venous blood sample was collected in controls, in AMI patients sample was collected before any intervention, and total cholesterol (TC), triglycerides (TG), and high density lipoprotein cholesterol (HDL-C) were measured. Low density lipoprotein cholesterol (LDL-C) and Very low density lipoprotein cholesterol (VLDL-C) were calculated by Friedwald's formula. Statistical analysis was done by Z test.
Results
The lipid profile was compared between Group A and Group B. There was a significant rise in TC, TG, LDL-C, VLDL-C and significant decrease in HDL-C in Group B as compared to Group A.
Conclusion
Cigarette smoking modulates the IHD risk through geneenvironment interaction and smoking increases the risk of atherosis. Further studies are required to ascertain the gene environment interaction .
Keywords
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