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A Pilot Syudy of Relation of Polycystic Ovary Syndrome and Metabolic Disorder in Davangere, Karnataka


Affiliations
1 Department of Obstetrics and Gynaecology, S.S.Institute of Medical Sciences & Research Centre, Davangere-577005, Karnataka, India
2 Department of Anatomy, S.S.Institute of Medical Sciences & Research Centre, Davangere-577005, Karnataka, India
3 Department of Forensic Medicine & Toxicology, S.S.Institute of Medical Sciences & Research Centre, Davangere-577005, Karnataka, India
4 Department of Surgical Oncology, S.S.Institute of Medical Sciences & Research Centre, Davangere-577005, Karnataka, India
     

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Introduction

Polycystic ovarian syndrome (PCOS) is seen in 5 - 10% of women of the reproductive age, is the most common form of anovulatory infertility.

Evidence prove that these women exhibit a characteristic dyslipidaemia non insulin dependent diabetes and cardiovascular disease in later life, which are the hallmarks of the metabolic syndrome.

Presence of 3 of 5 common cardiovascular risk factors as a criteria, the prevalence of metabolic syndrome in PCOS is very high (43 - 46%).

Primary infertility cases with clinical features of menstrual irregularities, weight gain, hirsutism, acne and galactorrhea with scan picture of polycystic ovaries were considered for diagnosing PCOS cases.

Aim of the Study

Aim is to establish the relation between PCOS and metabolic syndrome.

Material and Methods

Study Design

A prospective, noninterventional case control study was conducted with 60 primary infertility patients, attending the gynaecological department, S.S. Institute of Medical Sciences and Research Centre, Davangere, Karnataka.

Study population

All these patients had clinical features suggestive of PCOS, of these 30 patients with ultrasound findings of polycystic ovaries were taken as cases and the others were age matched contemporary controls.

Age group: 20 - 30 years. Duration of study: 8 months. (Dec. 2009 - July 2010)

Methodology

After a brief history, waist circumference and blood pressure was recorded, then patients were asked to come on overnight fasting for a fasting blood sugar level and lipid profile assessment.

Results

In the present study all the five parameters needed for diagnosing metabolic syndrome were raised in PCOS cases and compared to controls. Values were statistically significant by student's unpaired 't' test.

An incidence of 38% of metabolic syndrome was noted in the PCOS cases studied.

Conclusion

Women with PCOS were strongly associated with metabolic syndrome when compared with the controls.

Obesity, high triglycerides and low high  density lipoprotein levels are closely linked to insulin resistance and they are independent predictors of myocardial infarction and cardiovascular disease.

Results strongly indicate the need for comprehensive screening and education program for women of all ages with PCOS. Modification of lifestyle factors such as diet and exercise along with insulin sensitizers and lipid lowering agents can prevent long term health risks.


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  • Hull MGR. Epidemilogy of infertility and polycystic ovarian disease : endocrinological and demographic studies. Gynecol Endocrinol 1987;1(235-45).
  • Adams J, Polson DW, Franks S. Prevalenceof polycystic ovaries in women with anovulation and idiopathic hirsutism. Br Med J 1986;239:355-9.
  • Frank S. Polycystic ovary syndroem. N Engl J Med 1995;333:853- 861.
  • Glueck CJ, Papanna R, Wang P et al. Incidence and treatmetn of metabolic syndrome in newly referred women with confirmed polycystic ovary syndrome. Metabolism 2003;52:908-15.
  • Ford ES, Giles WH, Dietz WH. Prevalence of metabolic syndrome among us adults : findings from the third national health and trition examination survey. JAMA 2002;287:356-9.
  • Attaran Marjan. Polycystic ovary syndrome, cleveland clinicmeded 2004;1-8.
  • Conway G, Agarwal R, Betteridge DJ, Jacobs HS. Risk factors for coronary heart disease in lean and obese PCOS. Clin Endocrinol 1992;37:119-125.
  • Revised 2003 consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19-25.
  • Faloia E, Canibus P, Gatti C, Frezza F, et al. Body composition, fat distribution and metabolic characteristics in lean and obese women with polycystic ovary syndrome. J Endocrinol Invest 2004;27:424-9.
  • Dahlgren E, Janson PO, Johansson S. Polycystic ovary syndrome and risk for myocardial infarction evaluated for a risk factor model based on a prospective study of women. Acta Obstet Gynecol Scand 1992;71:599-604.
  • Legro RS, Kunselman AR, Dodson WC, Dunaif A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome : a prospective controlled study in 254 affected women. J Clin Endocrinol Metab 1999;84:165-9.
  • Gaziano JM, Hennekens CH, O’Donnell. Fasting triglycerides, high density lipoprotein and risk of myocardial infarction. Circulation 1997;96:2520-5.
  • Maruyama C, Imamura K, Teramato T. Assessment of LDL particle size by triglyceride / HDL cholesterol ratio in nondiabetic heatlhy subjects. J Atheroscler Thromb 2003;10:186-91.
  • McLaughlin T, Abbasi F, Cheal K, Chu J, et al. Use of metabolic markers identify overweight individuals who are insulin resistant. Ann Intern Med 2003;139:802-9.
  • Brehm A, Pfeiler G, et al. Relationship between serum lipopotein ratios and insulin resistance in obesity. Clin Chem 2004;54:2316-22.
  • Executive summary of the third report of the NECP, expert panel on detection, evaluation and treatment of high blood cholesterol in adults (ATP III). J Am Med Asso 2001;285:2486- 2497.
  • Barnard RJ, Wen SJ. Exercise and diet in the prevention and control of the metabolic syndrome. Sports Med 1994;18:218- 28.

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  • A Pilot Syudy of Relation of Polycystic Ovary Syndrome and Metabolic Disorder in Davangere, Karnataka

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Authors

Geetha Hosanemati
Department of Obstetrics and Gynaecology, S.S.Institute of Medical Sciences & Research Centre, Davangere-577005, Karnataka, India
Gayatri Patil
Department of Obstetrics and Gynaecology, S.S.Institute of Medical Sciences & Research Centre, Davangere-577005, Karnataka, India
Prema Prabhudev
Department of Obstetrics and Gynaecology, S.S.Institute of Medical Sciences & Research Centre, Davangere-577005, Karnataka, India
M. R. Anitha
Department of Anatomy, S.S.Institute of Medical Sciences & Research Centre, Davangere-577005, Karnataka, India
V. Vijayanath
Department of Forensic Medicine & Toxicology, S.S.Institute of Medical Sciences & Research Centre, Davangere-577005, Karnataka, India
L. S. Patil
Department of Surgical Oncology, S.S.Institute of Medical Sciences & Research Centre, Davangere-577005, Karnataka, India

Abstract


Introduction

Polycystic ovarian syndrome (PCOS) is seen in 5 - 10% of women of the reproductive age, is the most common form of anovulatory infertility.

Evidence prove that these women exhibit a characteristic dyslipidaemia non insulin dependent diabetes and cardiovascular disease in later life, which are the hallmarks of the metabolic syndrome.

Presence of 3 of 5 common cardiovascular risk factors as a criteria, the prevalence of metabolic syndrome in PCOS is very high (43 - 46%).

Primary infertility cases with clinical features of menstrual irregularities, weight gain, hirsutism, acne and galactorrhea with scan picture of polycystic ovaries were considered for diagnosing PCOS cases.

Aim of the Study

Aim is to establish the relation between PCOS and metabolic syndrome.

Material and Methods

Study Design

A prospective, noninterventional case control study was conducted with 60 primary infertility patients, attending the gynaecological department, S.S. Institute of Medical Sciences and Research Centre, Davangere, Karnataka.

Study population

All these patients had clinical features suggestive of PCOS, of these 30 patients with ultrasound findings of polycystic ovaries were taken as cases and the others were age matched contemporary controls.

Age group: 20 - 30 years. Duration of study: 8 months. (Dec. 2009 - July 2010)

Methodology

After a brief history, waist circumference and blood pressure was recorded, then patients were asked to come on overnight fasting for a fasting blood sugar level and lipid profile assessment.

Results

In the present study all the five parameters needed for diagnosing metabolic syndrome were raised in PCOS cases and compared to controls. Values were statistically significant by student's unpaired 't' test.

An incidence of 38% of metabolic syndrome was noted in the PCOS cases studied.

Conclusion

Women with PCOS were strongly associated with metabolic syndrome when compared with the controls.

Obesity, high triglycerides and low high  density lipoprotein levels are closely linked to insulin resistance and they are independent predictors of myocardial infarction and cardiovascular disease.

Results strongly indicate the need for comprehensive screening and education program for women of all ages with PCOS. Modification of lifestyle factors such as diet and exercise along with insulin sensitizers and lipid lowering agents can prevent long term health risks.


References