Indian Journal of Public Health Research & Development

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The Study of Sensorineural Hearing Loss in Pseudoexfoliation Syndrome


Affiliations
1 Department of Ophthalmoloy, Department of Biochemistry, Navodaya Medical College, Hospital and Research Centre, Raichur, Karnataka, India
2 Department of Otorhinolaryngology, Department of Biochemistry, Navodaya Medical College, Hospital and Research Centre, Raichur, Karnataka, India
3 Department of Orthopaedics, Department of Biochemistry, Navodaya Medical College, Hospital and Research Centre, Raichur, Karnataka, India
4 Department of Biochemistry, Navodaya Medical College, Raichur-584103, Karnataka, India
     

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Purpose: Determine hearing thresholds at sound frequencies important for speech comprehension in subject with ocular pseudoexfoliation (PXF) and to compare them with that of control without PXF.

Method: 60 subjects with ocular PXF and 60 age and sex matched controls without PXF were enrolled in this case-control study. Pure tone audiometry (bone conduction) was performed at 1,2 and 3 kilohertz (KHz) in all subjects. Thresholds were compared to an age and sex stratified standard (ISO7029) and between study groups. Hearing loss was defined as sum of tested hearing thresholds (HTL-1,2,3) lower than the ISO7029 standard median.

Results: The study included 35 males and 25 females subject in each group. Hearing loss was present in 97 of 120 (80.83%) of examined ears in the case group Vs 52 of 120 (43.3%) in the control group [P<0.001; odds ratio(OR) = 5.51; 95% confidence interval (CI) ]. overall 54 subjects ( 90%) in the case group Vs 37 subjects 61.6 % in the control group had hearing loss in one or both ears (P<0.001; odds ratio(OR) = 5.5; 95% confidence interval. Hearing thresholds at each of the examined frequencies and the HTL- 1,2,3 were also significantly higher in individuals with PXF.

Conclusions: Hearing thresholds at frequencies which are important for speech comprehension are significantly worse in individuals with ocular PXF as compared to matched controls. This finding may support the multi-organ nature of PXF syndrome.


Keywords

PXF Syndrome, Hearing Loss
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  • Ritch R, Schlotzer-Schtchardt U. Exfoliation syndrome. Sure Ophthalmol 2001; 45:265-315. Review .

  • Skuta GL, Morgan RK. Exfoliation syndrome, pigment dispersion syndrome and the associated glaucomas. In: Tasman W, Jaeger EA eds. Duanes clinical ophthalmology. On CD-ROM, New York: Lippincot; 2005: Vol 3, Chap 54B.

  • Young AL, Tang WW, Lam DS. The prevalence of pseudoexfoliation syndrome in Chinese people. Br J Ophthalmol 2004; 88: 193-195.

  • Streeten BW, Li ZY, Wallace RN, Eagle RC, Keshgegian AA. Pseudoexfoliative fibrillopathy in visceral organs of patient with pseudoexfoliation syndrome. Arch Ophthalmol 1992; 110; 1757-1762.

  • Yazdani Sh, Tousi A, Pakravan M, Faghihi AR. Sensorineural Hearing loss in Pseudoexfoliation Syndrome. Ophthalmology 2008; 115(3): 425-429.

  • Jafek BW, Stark AK 1st ed. Philadelphia: Hanley and Belfus Inc;1996. ENT secrets; pp. 11-26.

  • Lim DJ. Functional structure of the organ of corti: a review. Hear Res. 1986;22(1-3);117-146.

  • Tsuprun V, Santi P. Ultrastructural organization of proteoglycans and fibrillar matrix of the tectorial membrane. Hear Res. 1986;110(1-2): 107-118.

  • Shaban RI, Asfour WM. Ocular pseudoexfoliation associated with hearing loss. Saudi Medical Journal 2004; Vol 25 (9): 1254-1257.

  • Davis A. Epidemiology of hearing and balance disorder: Adult audiology. In: Kerr AG, Stephens D, editors. Scott – Brown’s Otolaryngology. 6th ed. Oxford. United Kingdom: Butterworth- Heinemann; 1997.pp 231-238.

  • Kerr AG ed. Epidemiology. In : Scott-Brown’s Otolaryngology. 6th ed. Oxford : Butterworth- Heinemann;1997: Vol 2, Chap 3

  • Goodwin WJ, Balkany T, Casiano RR. Special considerations in managing geriatric patients. In: Cummings CW ed. Otolaryngology & head & neck surgery. 3rd ed. St Louis: Mosby; 1998: 314-326.

  • Thalman I. Collagen of accessory structures of the organ of the corti. Connect Tissue Res 1993; 29: 191-201.

  • Kalluri R, Gattone VH 2nd, Hudson BG. Identification and localisation of type IV collagen chains in the inner ear cochlea. Connect Tissue Res 1998;37: 143-150.

  • Mitchell P, Wang JJ, Smith W. Association of pseudoexfoliation syndrome with increased vascular risk. Am J Ophthalmol 1997; 124: 685-687.

  • Saatci OA, Ferliel ST , Ferliel M, Kaynak S, Ergin MH. Pseudoexfoliation and glaucoma in eyes with retinal vein occlusion. Int Ophthalmol1999;23: 75-78.


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  • The Study of Sensorineural Hearing Loss in Pseudoexfoliation Syndrome

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Authors

Sameena Kokab
Department of Ophthalmoloy, Department of Biochemistry, Navodaya Medical College, Hospital and Research Centre, Raichur, Karnataka, India
Jyothi Chavadaki
Department of Otorhinolaryngology, Department of Biochemistry, Navodaya Medical College, Hospital and Research Centre, Raichur, Karnataka, India
S Neelkant
Department of Orthopaedics, Department of Biochemistry, Navodaya Medical College, Hospital and Research Centre, Raichur, Karnataka, India
Sreekantha
Department of Biochemistry, Navodaya Medical College, Raichur-584103, Karnataka, India

Abstract


Purpose: Determine hearing thresholds at sound frequencies important for speech comprehension in subject with ocular pseudoexfoliation (PXF) and to compare them with that of control without PXF.

Method: 60 subjects with ocular PXF and 60 age and sex matched controls without PXF were enrolled in this case-control study. Pure tone audiometry (bone conduction) was performed at 1,2 and 3 kilohertz (KHz) in all subjects. Thresholds were compared to an age and sex stratified standard (ISO7029) and between study groups. Hearing loss was defined as sum of tested hearing thresholds (HTL-1,2,3) lower than the ISO7029 standard median.

Results: The study included 35 males and 25 females subject in each group. Hearing loss was present in 97 of 120 (80.83%) of examined ears in the case group Vs 52 of 120 (43.3%) in the control group [P<0.001; odds ratio(OR) = 5.51; 95% confidence interval (CI) ]. overall 54 subjects ( 90%) in the case group Vs 37 subjects 61.6 % in the control group had hearing loss in one or both ears (P<0.001; odds ratio(OR) = 5.5; 95% confidence interval. Hearing thresholds at each of the examined frequencies and the HTL- 1,2,3 were also significantly higher in individuals with PXF.

Conclusions: Hearing thresholds at frequencies which are important for speech comprehension are significantly worse in individuals with ocular PXF as compared to matched controls. This finding may support the multi-organ nature of PXF syndrome.


Keywords


PXF Syndrome, Hearing Loss

References