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A Comparative Study of Lipid Profile in Tobacco Chewers in Pune District


Affiliations
1 Department of Biochemistry, Saraswathi Institute of Medical Sciences, Panchsheel Nagar, U.P., India
2 Department of Biochemistry, Dr. D.Y. Patil Medical College Pune, Maharashtra, India
     

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Objective: The present study was undertaken to assess the association between the tobacco chewing and alteration in plasma lipid profile.

Method: 300 cases of tobacco chewing between the ages of 20-50 years were included in the study and 300 age matched non-tobacco users served as control. Serum lipid profile was determined by enzymatic methods by kits obtained from Sigma-Aldrich.

Results: High density lipoprotein cholesterol was significantly lower in tobacco chewers than the controls. Total cholesterol, low density lipoprotein cholesterol, very low density lipoprotein cholesterol and, triglycerides was significantly higher in tobacco chewers as compared to non-tobacco user control group.

Conclusion: Our findings suggest that tobacco chewing causes significant dyslipidemia in the direction that increases the cardiovascular risk.


Keywords

TC-Total Cholesterol, LDLC-Low Density Lipoprotein Cholesterol, VLDLC-Very Low Density Lipoprotein Cholesterol, HDLC-High Density Lipoprotein-Cholesterol, TG-TriGlyceride
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  • David M. Burns – Nicotine Addiction – Chapter 375 – Harrison’s principles of InternalMedicine; Vol.II ; 16th Edition ; 2005; 2573-2576.
  • World Health Report 2002. Reducing Risks, Promoting Healthy Life; Geneva. World Health Organization; 2002; 47-98.
  • World Health Report 2003. Neglected Global Epidemics, three growing threats. World Health Organization 2003; 85-95.
  • International institute for Population Sciences and ORC Macro International. National Family Health Survey (NFHS-3), 2005-2006: India, IIPS, Mumbai, 2007, vol.II, pp. 426-429.
  • Jojn, R.M., Household’s tobacco consumption decisions: evidence from India. J. South Asian Dev., 2006, 1, 119-147.
  • Henningfield, J.E. and Benowitz, N.L., Pharmacology of nicotine addiction. In Tobacco: Science, Policy and Public Health (eds Boyle, P. Et al.), Oxford University Press, Oxford, 2004, pp. 129-147.
  • Hoffmann D, Harley NH, Fisenne I, Adams JD, Brunnemann KD: Carcinogenic agents in snuff. JNCI 1986; 76:435-437.
  • Benowitz NL, Hallsm, Herning RI, Jacob piii, Jones RT, Osman AL: Smokers of low-yield cigarettes do not consume less nicotine. N. Engl J Med 1983; 309: 139-142.
  • Russel MAH, Jarvis MJ, West RJ, et al: Buccal absorption of nicotine from smokeless tobacco sachets (letter). Lancet 1985; 2(8468):1370.
  • Shennan NM, Seed M, Wynn V: Variation in serum lipid and lipoprotein levels associated with changes in smoking behavior in non-obese Caucasian males. Atherosclerosis December 1985; 58(1/3):17-25.
  • Brunner D, Altman S, Loebl K, Schwartz S, Levin S: Serum Cholesterol and triglycerides in patients suffering from ischemic heart disease and in healthy subjects. Atherosclerosis 1977; 28: 197-204.
  • Kaplan, M.M. Clinical and laboratory assessment of thyroid abnormalities. Med. Clin. North. Amer.1985; 5:69-71.
  • Palkonen, R., Foegelholm, R., Nikkila, E.A. Increase in serum cholesterol during Phenytoin treatment. Br. Med. J.1975;4:85-87.
  • Nikkila, E.A., Kaste, M., Ehnbolm, C., Viikari, J. Increase in serum high-density lipoprotein in Phenytoin users. Br. Med. J.1978; 2: 99-103.
  • Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18:499-502.
  • Pais P, Fay MP, Yusuf S. Increased risk of acute myocardial infarction associated with Qbeedi and cigareete smoking in Indians: final report on tobacco risks from a case-control study. Indian Heart J2001; 53; 731-5.
  • Cluette Brown J. Mulligan J. Doyle K. Hagan S. Osmolski T. And Hojnocki J: Oral nicotine induces an atherogenic lipoprotein profile. Proc Soc Exp Biol Med 182:409-413.1986.
  • Khurana M, Sharma D, Khandelwal PD. Lipid profile in smokers and tobacco Chewers—a comparative study.The Journal of the Assosiation of Physicians of India 48(9):895-7,2000Sep.
  • Richter, P. And Watson, C., Chemistry and toxicology. In Bidi Smoking and Public Health (eds Gupta P.C. and Asma, S.), Ministry of Health and Family Welfare, Government of India, 2008, pp. 61-100.
  • Ritesh Gupta,MD, MPH,Hitinder Gurm, MD; John Bartholomew, MD Smokeless Tobacco and Cardiovascular Risk. Arch Intern Med. 2004; 164:1845-1849.
  • Gupta R. Sharma SC, Gupta VP, Gupta KD. Smoking and alcohol intake in a rural Indian Population and correlation with hypertension and coronary heart disease prevalence. J. Assoc Physicians India 1995; 43: 153-8.

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  • A Comparative Study of Lipid Profile in Tobacco Chewers in Pune District

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Authors

Sandeep Kumar Sharma
Department of Biochemistry, Saraswathi Institute of Medical Sciences, Panchsheel Nagar, U.P., India
U K More
Department of Biochemistry, Dr. D.Y. Patil Medical College Pune, Maharashtra, India

Abstract


Objective: The present study was undertaken to assess the association between the tobacco chewing and alteration in plasma lipid profile.

Method: 300 cases of tobacco chewing between the ages of 20-50 years were included in the study and 300 age matched non-tobacco users served as control. Serum lipid profile was determined by enzymatic methods by kits obtained from Sigma-Aldrich.

Results: High density lipoprotein cholesterol was significantly lower in tobacco chewers than the controls. Total cholesterol, low density lipoprotein cholesterol, very low density lipoprotein cholesterol and, triglycerides was significantly higher in tobacco chewers as compared to non-tobacco user control group.

Conclusion: Our findings suggest that tobacco chewing causes significant dyslipidemia in the direction that increases the cardiovascular risk.


Keywords


TC-Total Cholesterol, LDLC-Low Density Lipoprotein Cholesterol, VLDLC-Very Low Density Lipoprotein Cholesterol, HDLC-High Density Lipoprotein-Cholesterol, TG-TriGlyceride

References