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Evaluation of the Antioxidant Levels and HbA1c of Type 2 Diabetes Patients


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1 Biology Department, Iraqi University, Iraq
     

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Type 2 Diabetes Mellitus is a chronic and inflammatory disease, characterized by chronic hyperglycemia associated with ROS generation, oxidative stress and lipid peroxidation. A cross-sectional study was conducted with T2DM (n=60, male) aged over 40 years and nondiabetic control (n=30, male) with same age. All patients provided a written informed consent before the start of the study procedures. In the present study, we reported high differences (p≤0.01) in the antioxidants values (MDA, CAT, SOD, GPX and GSH) compared with control, value of HBA1c and duration of infection. High HbA1c is an indicator of high antioxidant enzymes activity. Serum MDA level was increased significantly in diabetes mellitus patients with a simultaneous decreased in SOD and CAT levels. Diabetes induces alteration in activity GPX and GSH. The hyperglycemia change the oxidative status which, in turn affects the endogenous antioxidant status in T2DM. They have high risk of experiencing micro and macrovascular complications. In addition to the combination of diet, exercise and medication can improve the level of HbA1c in T2DM. Further studies should be conducted to strengthen this evidence.

Keywords

HbA1c, T2DM, MDA, SOD, GPX.
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  • Evaluation of the Antioxidant Levels and HbA1c of Type 2 Diabetes Patients

Abstract Views: 91  |  PDF Views: 0

Authors

Qussay Noori Raddam
Biology Department, Iraqi University, Iraq
Ola Hassan Hadi
Biology Department, Iraqi University, Iraq

Abstract


Type 2 Diabetes Mellitus is a chronic and inflammatory disease, characterized by chronic hyperglycemia associated with ROS generation, oxidative stress and lipid peroxidation. A cross-sectional study was conducted with T2DM (n=60, male) aged over 40 years and nondiabetic control (n=30, male) with same age. All patients provided a written informed consent before the start of the study procedures. In the present study, we reported high differences (p≤0.01) in the antioxidants values (MDA, CAT, SOD, GPX and GSH) compared with control, value of HBA1c and duration of infection. High HbA1c is an indicator of high antioxidant enzymes activity. Serum MDA level was increased significantly in diabetes mellitus patients with a simultaneous decreased in SOD and CAT levels. Diabetes induces alteration in activity GPX and GSH. The hyperglycemia change the oxidative status which, in turn affects the endogenous antioxidant status in T2DM. They have high risk of experiencing micro and macrovascular complications. In addition to the combination of diet, exercise and medication can improve the level of HbA1c in T2DM. Further studies should be conducted to strengthen this evidence.

Keywords


HbA1c, T2DM, MDA, SOD, GPX.



DOI: https://doi.org/10.37506/v11%2Fi2%2F2020%2Fijphrd%2F195091