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Allopurinol Versus Epinephrine in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis


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1 Tropical Medicine Minia University, Egypt
     

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This study was to evaluate and investigate the effects of using different drugs on reducing the frequency and severity of Post- ERCP pancreatitis. The study was done on 90 randomized patients with extrahepatic cholestasis and divided into three groups. Post ERCP pancreatitis was diagnosed by laboratory investigations, ultra-sonography and triphasic abdominal CT criteria of pancreatitis. The results of this study showed that there was a statistically significant difference in the percentage of knife precut between the studied groups. There was a statistically significant difference in the degree of post ERCP pancreatitis during comparison the control group with each studied drug group, in which allopurinol has a protective role in the occurrence of post ERCP pancreatitis by regression analysis. It is concluded to use allopurinol before ERCP procedure.

Keywords

ERCP, Pancreatitis, Knife Precut, Allopurinol.
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  • Allopurinol Versus Epinephrine in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis

Abstract Views: 103  |  PDF Views: 0

Authors

Mohamed Abdelhakim Abdelaleem Elsherbiny
Tropical Medicine Minia University, Egypt
Madeha Mohamed Ahmed Makhlof
Tropical Medicine Minia University, Egypt
Ayman Mohamed Hassanin Hassan
Tropical Medicine Minia University, Egypt
Hala Ibrahem Mohamed Ahmed
Tropical Medicine Minia University, Egypt
Magdy Fouad Ahmed Mahmoud
Tropical Medicine Minia University, Egypt

Abstract


This study was to evaluate and investigate the effects of using different drugs on reducing the frequency and severity of Post- ERCP pancreatitis. The study was done on 90 randomized patients with extrahepatic cholestasis and divided into three groups. Post ERCP pancreatitis was diagnosed by laboratory investigations, ultra-sonography and triphasic abdominal CT criteria of pancreatitis. The results of this study showed that there was a statistically significant difference in the percentage of knife precut between the studied groups. There was a statistically significant difference in the degree of post ERCP pancreatitis during comparison the control group with each studied drug group, in which allopurinol has a protective role in the occurrence of post ERCP pancreatitis by regression analysis. It is concluded to use allopurinol before ERCP procedure.

Keywords


ERCP, Pancreatitis, Knife Precut, Allopurinol.



DOI: https://doi.org/10.37506/v11%2Fi2%2F2020%2Fijphrd%2F195067