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Predicting Patient Survival after Pancreaticoduodenectomy for Malignancy Based on Histopathological Criteria


Affiliations
1 Medicine-Minia University, Egypt
2 National Liver Institute- Menoufiya University, Egypt
     

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This Study Aimed to identify histopathological variables that might contribute to survival, mortality of patients,and serious complications after pancreaticoduodenectomy.

Patients and Method: This is prospective hospital based study that been done on all patients who underwent pancreaticoduodenectomy in National Liver Institute and Minia university hospital between the first of January 2015 till the end of December 2016. in the surgical department, National Liver Institute, Menoufiya University and Minia university hospital.

Results: We found that perineural infiltration and lymphovascular invasion were independently significant in multivariate analysis, the effects of combining them in terms of predicting longterm survival is very important .Smaller and well-differentiated tumours were associated with significantly better patient survival (P < 0.03 and P < 0.01, respectively). Positive lymph nodes were associated with reduced survival (P < 0.003).

Conclusion: The analyse the histopathological parameters influencing longterm patient survival after pancreaticoduodenectomy focusing on perineural infiltration and lymphovascular invasion as predictors of longterm survival


Keywords

Pancreaticoduodenectomy, Histopathological, Tumours.
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  • Predicting Patient Survival after Pancreaticoduodenectomy for Malignancy Based on Histopathological Criteria

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Authors

Michael Remon Roshdy
Medicine-Minia University, Egypt
Abu Bakr Mohammad Mohie EL-Din
Medicine-Minia University, Egypt
Khaled Aly Abou EL-ella
National Liver Institute- Menoufiya University, Egypt
Nasser Mohammad Zaghloul
Medicine-Minia University, Egypt
Motassem Mohammad Ali
Medicine-Minia University, Egypt

Abstract


This Study Aimed to identify histopathological variables that might contribute to survival, mortality of patients,and serious complications after pancreaticoduodenectomy.

Patients and Method: This is prospective hospital based study that been done on all patients who underwent pancreaticoduodenectomy in National Liver Institute and Minia university hospital between the first of January 2015 till the end of December 2016. in the surgical department, National Liver Institute, Menoufiya University and Minia university hospital.

Results: We found that perineural infiltration and lymphovascular invasion were independently significant in multivariate analysis, the effects of combining them in terms of predicting longterm survival is very important .Smaller and well-differentiated tumours were associated with significantly better patient survival (P < 0.03 and P < 0.01, respectively). Positive lymph nodes were associated with reduced survival (P < 0.003).

Conclusion: The analyse the histopathological parameters influencing longterm patient survival after pancreaticoduodenectomy focusing on perineural infiltration and lymphovascular invasion as predictors of longterm survival


Keywords


Pancreaticoduodenectomy, Histopathological, Tumours.



DOI: https://doi.org/10.37506/v11%2Fi2%2F2020%2Fijphrd%2F195065