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Central Venous and Arterial Gases Level Versus Lactate Clearance as an Indicator of Initial Resuscitation in Septic Patients in Intensive Care Unit


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1 Intensive Care and Pain Management, Minia University, Egypt
     

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Objective: Aim of this study was to compare the central venoarterial carbon dioxide difference/arterial-central venous oxygen difference (P(va)CO2/C(a-v)O2) ratio versus lactate clearance as an indicator to evaluate the steps of initial resuscitation in septic patients.

Patients and Method: Our study was conducted in the ICU,Minia University Hospital. Eighty patients with severe sepsis or septic shock

Results: There was improvement in CVP, MAP, or Scvo2 at T8 after early resuscitation with no significant differences between group 1 and group 2 and inside each group. There were no significant difference in P(v-a)CO2/C(a-v)O2 ratio at T0 and at T8 at group 1. However there was higher lactate level at T0 and exhibited significantly lower at T8 in group 2.

Conclusion: Further clinical trials are needed to conclusively establish lactate clearance as a resuscitation endpoint and an outcome measure to be targeted during the most proximal phases of severe sepsis and septic shock.


Keywords

CVP, MAP, Scvo2.
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  • Central Venous and Arterial Gases Level Versus Lactate Clearance as an Indicator of Initial Resuscitation in Septic Patients in Intensive Care Unit

Abstract Views: 92  |  PDF Views: 0

Authors

Ibrahim Abas Youseif
Intensive Care and Pain Management, Minia University, Egypt
Ahmad Hasaneen Mohammed
Intensive Care and Pain Management, Minia University, Egypt
Rehab Mohammed Farghly
Intensive Care and Pain Management, Minia University, Egypt

Abstract


Objective: Aim of this study was to compare the central venoarterial carbon dioxide difference/arterial-central venous oxygen difference (P(va)CO2/C(a-v)O2) ratio versus lactate clearance as an indicator to evaluate the steps of initial resuscitation in septic patients.

Patients and Method: Our study was conducted in the ICU,Minia University Hospital. Eighty patients with severe sepsis or septic shock

Results: There was improvement in CVP, MAP, or Scvo2 at T8 after early resuscitation with no significant differences between group 1 and group 2 and inside each group. There were no significant difference in P(v-a)CO2/C(a-v)O2 ratio at T0 and at T8 at group 1. However there was higher lactate level at T0 and exhibited significantly lower at T8 in group 2.

Conclusion: Further clinical trials are needed to conclusively establish lactate clearance as a resuscitation endpoint and an outcome measure to be targeted during the most proximal phases of severe sepsis and septic shock.


Keywords


CVP, MAP, Scvo2.



DOI: https://doi.org/10.37506/v11%2Fi2%2F2020%2Fijphrd%2F195061