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Neurological And Non Neurological Role of Brain-Derived Neurotrophic Factor (BDNF) in Developing Jaw


Affiliations
1 Assistance Lecturer at College of Dentistry, Mustansiriya University, Baghdad, Iraq
2 Assistance Lecturerat, Al-Mustaqbal University College/Dentistry Department, Babel, Iraq
3 Professor, Al-Mustaqbal University College/Dentistry Department, Babel
4 Teaching Assistantat, Al-Mustaqbal University College/Dentistry Department, Babel, Iraq
     

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Background: Brain-derived neurotrophic factor (BDNF), recognized to be involved in differentiation and proliferation of specialized cell such as endothelial cell and osteoblast cell. Aim of the Study: The study was designed to identify the effect of exogenous BDNF on development of jaw and on neural marker expression. Materials and Method: Twenty pregnant rats,ten injected (I.M) with normal saline,other ten injected (I.M) with 0.1 ml of BDNF that received three doses at intervals (0,7,14 day of gestation period).Embryos at 16th and 18th intra-uterine life were used for histological and immunohistochemical evaluation for the development of prenatal jaw. Results: Illustrate an enhancement of bone development during proceeding embryonic periods for both study groups .Moreover, the experimental group shows a high significant difference in the mean of bone cell count at the period 18th day in comparisum to 16th day IUL,and in comparisum to control at 18th day IUL. Results show positive expression of neuronal marker by proliferating nerve cells in control and experimental groups with significant difference. Conclusion: The study suggest that BDNF contributes to promoting the differentiation of bone cells and enhancement of bone formation by increasing expression of neuron marker.

Keywords

Brain derived neurotrophic factor, bone, embryogenesis, osteogenic cell, bone stem cell, rat development.
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  • Neurological And Non Neurological Role of Brain-Derived Neurotrophic Factor (BDNF) in Developing Jaw

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Authors

Noor Natik Raheem
Assistance Lecturer at College of Dentistry, Mustansiriya University, Baghdad, Iraq
Mohammed Faris
Assistance Lecturerat, Al-Mustaqbal University College/Dentistry Department, Babel, Iraq
Athraa Y. Al-Hijazi
Professor, Al-Mustaqbal University College/Dentistry Department, Babel
Ali I Alqurshi
Teaching Assistantat, Al-Mustaqbal University College/Dentistry Department, Babel, Iraq

Abstract


Background: Brain-derived neurotrophic factor (BDNF), recognized to be involved in differentiation and proliferation of specialized cell such as endothelial cell and osteoblast cell. Aim of the Study: The study was designed to identify the effect of exogenous BDNF on development of jaw and on neural marker expression. Materials and Method: Twenty pregnant rats,ten injected (I.M) with normal saline,other ten injected (I.M) with 0.1 ml of BDNF that received three doses at intervals (0,7,14 day of gestation period).Embryos at 16th and 18th intra-uterine life were used for histological and immunohistochemical evaluation for the development of prenatal jaw. Results: Illustrate an enhancement of bone development during proceeding embryonic periods for both study groups .Moreover, the experimental group shows a high significant difference in the mean of bone cell count at the period 18th day in comparisum to 16th day IUL,and in comparisum to control at 18th day IUL. Results show positive expression of neuronal marker by proliferating nerve cells in control and experimental groups with significant difference. Conclusion: The study suggest that BDNF contributes to promoting the differentiation of bone cells and enhancement of bone formation by increasing expression of neuron marker.

Keywords


Brain derived neurotrophic factor, bone, embryogenesis, osteogenic cell, bone stem cell, rat development.



DOI: https://doi.org/10.37506/v11%2Fi2%2F2020%2Fijphrd%2F195050