Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Association of Prothrombin G20210A Mutation with Unexplained Recurrent Pregnancy Loss


Affiliations
1 Assistant Professor of Clinical Pathology, Faculty of Medicine, Minia University, Egypt
2 Professor of Clinical Pathology, Faculty of Medicine, Minia University, Egypt
     

   Subscribe/Renew Journal


Purpose: To assess the relationship of Prothrombin G20210A gene mutations as a risk factor for idiopathic repeated pregnancy loss. The focus has been on Prothrombin G20210 Amutation that may predispose women to microthrombosis during the stages of embryo implantation and placentation. Method: A total of 70 women with recurrent pregnancy loss, mean age 31.1±4.2 years, were involved in the study. As a control group, 70 women [mean age 32.2±3.3y ears with at least two live-born child and no history of abortion were included. We used real-time polymerase chain reaction (PCR) to determine the frequencies of Prothrombin G20210 Agenotype. Results: The frequency of heterozygotes for F2 was significantly higher in women with repeated pregnancy loss compared to women without abortion (p = 0.0001). Conclusion: In summary we found an association of prothrombin G20210A mutation with recurrent pregnancy loss .we recommend for prothrombin G20210A screening in cases with repeated pregnancy loss so they can start anticoagulant therapy more earlier

Keywords

Prothrombin G20210A; pregnancy; PCR
Subscription Login to verify subscription
User
Notifications
Font Size


Abstract Views: 99

PDF Views: 0




  • Association of Prothrombin G20210A Mutation with Unexplained Recurrent Pregnancy Loss

Abstract Views: 99  |  PDF Views: 0

Authors

Ayman Gamil Ghobrial
Assistant Professor of Clinical Pathology, Faculty of Medicine, Minia University, Egypt
Asmaakhalaf Allakamel Ezz Eldein
Assistant Professor of Clinical Pathology, Faculty of Medicine, Minia University, Egypt
Esmat Abd El Aziz El Sharkawy
Professor of Clinical Pathology, Faculty of Medicine, Minia University, Egypt
Khalid Mohammed Salah
Professor of Clinical Pathology, Faculty of Medicine, Minia University, Egypt
Mostafa Ahmed Abu Elela
Assistant Professor of Clinical Pathology, Faculty of Medicine, Minia University, Egypt
Aliaa Mohammed Monir Ali Higazi
Assistant Professor of Clinical Pathology, Faculty of Medicine, Minia University, Egypt

Abstract


Purpose: To assess the relationship of Prothrombin G20210A gene mutations as a risk factor for idiopathic repeated pregnancy loss. The focus has been on Prothrombin G20210 Amutation that may predispose women to microthrombosis during the stages of embryo implantation and placentation. Method: A total of 70 women with recurrent pregnancy loss, mean age 31.1±4.2 years, were involved in the study. As a control group, 70 women [mean age 32.2±3.3y ears with at least two live-born child and no history of abortion were included. We used real-time polymerase chain reaction (PCR) to determine the frequencies of Prothrombin G20210 Agenotype. Results: The frequency of heterozygotes for F2 was significantly higher in women with repeated pregnancy loss compared to women without abortion (p = 0.0001). Conclusion: In summary we found an association of prothrombin G20210A mutation with recurrent pregnancy loss .we recommend for prothrombin G20210A screening in cases with repeated pregnancy loss so they can start anticoagulant therapy more earlier

Keywords


Prothrombin G20210A; pregnancy; PCR



DOI: https://doi.org/10.37506/v11%2Fi2%2F2020%2Fijphrd%2F195032