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Biochemical Studies of Oxidative Stress During Ischemia Induce Myocardial Injuries


Affiliations
1 MSc., Department of Chemistry, College of Science, Kirkuk University, Kirkuk, Iraq
2 Assistant Professor, Department of Chemistry, College of Science, Kirkuk University, Kirkuk, Iraq
3 Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq
     

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The study was designed as a biochemical study of the oxidative stress during hypotension caused by cardiac injury, the world’s first cause of death, using biomarkers and their role in laboratory diagnosis. The study included three sets of 40 blood samples from each people with myocardial infarction, angina pectoris and healthy people as a control group. Different biochemical variables such as ROS, GPX1, Troponin, C.K, and lipid profile were measured,and the results showed a significant increase in the level of concentration of Reactive Oxygen Species ROS (P-value 0,045) in patients with MI, (7.326 ±1.143ng/mL), and the Angina Pectoris was (6.037 ±1.669ng/mL) compared with the control group (1.046 ± 5.158ng/mL)A significant decrease in the level of Glutathione peroxidase GPX1 at the level of (P-value 0.038) in patients with myocardial infarction (1890 ±391pg/mL) was observed, while in Angina Pectoris was (2109 ±600pg/mL) and in control was (2386±401pg/mL) Furthermore, a varying rises in the level of troponin and creatine kinase in patients with myocardial infarction(29.03±22.99 ng/mL, 110.62±45.71 u/L)respectively, while in patients with Angina was (2.181±2.186 ng/mL, 39.730±12.79 u/L) compared with the control(0.139±0.1717 ng/mL, 16.283±5.133 u/L). The results of the study showed a significant increase of lipid profile (cholesterol, triglycerides, HDL)in patients with MI and AP, with an average concentration (344.6±67.4, 240.3±58.5, 43.00±6.89 mg/dL) for MI and (303.6 ± 86.1, 232.8 ± 65.8, 39.10 ± 5.86) for AP compared with the control group, with an average concentration Mean ± SD (159.2 ± 50.30, 102.9 ± 35.60, 31.00 ± 3.085) respectively.

Keywords

Cardiac injury, myocardial infarction, angina pectoris, Glutathione peroxidase 1, Reactive Oxygen Species
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  • Biochemical Studies of Oxidative Stress During Ischemia Induce Myocardial Injuries

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Authors

Deine Majeed Qadir
MSc., Department of Chemistry, College of Science, Kirkuk University, Kirkuk, Iraq
Mohsin Omar Mohammed
Assistant Professor, Department of Chemistry, College of Science, Kirkuk University, Kirkuk, Iraq
Mustafa Taha Mohammed
Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq

Abstract


The study was designed as a biochemical study of the oxidative stress during hypotension caused by cardiac injury, the world’s first cause of death, using biomarkers and their role in laboratory diagnosis. The study included three sets of 40 blood samples from each people with myocardial infarction, angina pectoris and healthy people as a control group. Different biochemical variables such as ROS, GPX1, Troponin, C.K, and lipid profile were measured,and the results showed a significant increase in the level of concentration of Reactive Oxygen Species ROS (P-value 0,045) in patients with MI, (7.326 ±1.143ng/mL), and the Angina Pectoris was (6.037 ±1.669ng/mL) compared with the control group (1.046 ± 5.158ng/mL)A significant decrease in the level of Glutathione peroxidase GPX1 at the level of (P-value 0.038) in patients with myocardial infarction (1890 ±391pg/mL) was observed, while in Angina Pectoris was (2109 ±600pg/mL) and in control was (2386±401pg/mL) Furthermore, a varying rises in the level of troponin and creatine kinase in patients with myocardial infarction(29.03±22.99 ng/mL, 110.62±45.71 u/L)respectively, while in patients with Angina was (2.181±2.186 ng/mL, 39.730±12.79 u/L) compared with the control(0.139±0.1717 ng/mL, 16.283±5.133 u/L). The results of the study showed a significant increase of lipid profile (cholesterol, triglycerides, HDL)in patients with MI and AP, with an average concentration (344.6±67.4, 240.3±58.5, 43.00±6.89 mg/dL) for MI and (303.6 ± 86.1, 232.8 ± 65.8, 39.10 ± 5.86) for AP compared with the control group, with an average concentration Mean ± SD (159.2 ± 50.30, 102.9 ± 35.60, 31.00 ± 3.085) respectively.

Keywords


Cardiac injury, myocardial infarction, angina pectoris, Glutathione peroxidase 1, Reactive Oxygen Species



DOI: https://doi.org/10.37506/v11%2Fi2%2F2020%2Fijphrd%2F194967