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In Silico Comparative Studies on Cytokine Receptor “Interleukin-11 Receptor” of Human, Rat and Mouse


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1 Researcher, Science Department, College of basic education, University of Sumer, ThiQar, Iraq
     

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Objectives: Interleukin-11 receptor with an imperative multifunctional role In normal cell signals and also in different pathologies, Interleukin-11 receptor with many statistical method obviously show how this protein is estimated to include possibly disordered regions in association with normal bonding partnerships. Method: The Interleukin-11 receptor conducted a concise comparative bioinformatic analysis of three different types of human, mouse and rat. The study was conducted using numerous statistical method to examine the function-correlation and structure of their corresponding amino acid sequences and the associated protein sequences. Physico-chemical properties, sequence conservation, and secondary functional details are studied on the basis of specific bioinformatics tools and techniques. Findings: in order to recognize both structural diversity and sequence, different bioinformatics techniques were used. Interleukin-11 receptor’s initial sequence analysis showed that they shared 86.1% similarity of the mouse and 81.9% identification of 85.4% and 80.5% identity of the rat similarity. With few exceptions, all sequences presented a high level of sequence survival. The physico-chemical analysis verified that there was no high evolutionary distance between mouse, rats and humans. Analysis of retained domains showed a clear structure of clustering, which also indicated the ancestral of the elationship among mouse, rat and human. The results suggest that IL may have originated from a common ancestor and may have diverged genetically in the course of evolution. Those studies will help the researchers to investigate the IL receptors functional differentiation and substratum binding process. Applications: Understand the evolutionary relationship and the sequence survival among humans, rats and mouse, which may lead to further studies in proteomics.

Keywords

Silico, Cytokine Receptor, Interleukin-11 receptor
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  • In Silico Comparative Studies on Cytokine Receptor “Interleukin-11 Receptor” of Human, Rat and Mouse

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Authors

Ashraf Fadhil Jomah
Researcher, Science Department, College of basic education, University of Sumer, ThiQar, Iraq

Abstract


Objectives: Interleukin-11 receptor with an imperative multifunctional role In normal cell signals and also in different pathologies, Interleukin-11 receptor with many statistical method obviously show how this protein is estimated to include possibly disordered regions in association with normal bonding partnerships. Method: The Interleukin-11 receptor conducted a concise comparative bioinformatic analysis of three different types of human, mouse and rat. The study was conducted using numerous statistical method to examine the function-correlation and structure of their corresponding amino acid sequences and the associated protein sequences. Physico-chemical properties, sequence conservation, and secondary functional details are studied on the basis of specific bioinformatics tools and techniques. Findings: in order to recognize both structural diversity and sequence, different bioinformatics techniques were used. Interleukin-11 receptor’s initial sequence analysis showed that they shared 86.1% similarity of the mouse and 81.9% identification of 85.4% and 80.5% identity of the rat similarity. With few exceptions, all sequences presented a high level of sequence survival. The physico-chemical analysis verified that there was no high evolutionary distance between mouse, rats and humans. Analysis of retained domains showed a clear structure of clustering, which also indicated the ancestral of the elationship among mouse, rat and human. The results suggest that IL may have originated from a common ancestor and may have diverged genetically in the course of evolution. Those studies will help the researchers to investigate the IL receptors functional differentiation and substratum binding process. Applications: Understand the evolutionary relationship and the sequence survival among humans, rats and mouse, which may lead to further studies in proteomics.

Keywords


Silico, Cytokine Receptor, Interleukin-11 receptor



DOI: https://doi.org/10.37506/v11%2Fi2%2F2020%2Fijphrd%2F194959