Impact of Cervical Infection with Bacteria Ureaplasma Urealyticum to Interleukin-1α-Expression in Pregnant Women

Pregnant women could be at risk of developing complications in genital tract when infected with the bacteria Ureaplasma urealyticum. The objective of this study was to assess the impact of genital infection in pregnant women, in Kirkuk city, relevant to both gestational age and level of Interleukine (IL-1α). Fifty five pregnant women were involved whose ages ranged between 18-45 years. Double swab samples from cervix were collected i.e. the first swab used to detect U. urealyticum while the second to assess the level of IL-1α cytokine. Only 45% of pregnant women were infected with U. urealyticum, with the highest positive U. urealyticum infection among age group (18-31 years) (40%), while the older women had less infection frequency (5%). The significantly highest (p≤0.05) distribution percentage was amongst third trimester gestation (33%). Genital expression of IL-1-α had significantly (p≤0.05)elevated during the infection (189±3.3pg/mL) in comparison with non-infected pregnant women. The level of IL-1α was elevated significantly(p≤0.05) among women in third trimester of pregnancy in comparison with second and first trimester, respectively. A significant correlation between U. urealyticum infection and elevationin the level of IL-1αis established.