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Impact of Cervical Infection with Bacteria Ureaplasma Urealyticum to Interleukin-1α-Expression in Pregnant Women


Affiliations
1 Directorate of Health, Kirkuk, Clinical Laboratory, Directorate of Health, Baghdad Road, Iraq
2 Faculty of Nursury, Assistant Professor, Vice Dean of Faculty of Pharmacy, University of Kirkuk, Iraq
3 Department of Anatomy, Faculty of Veterinary Medicine, University of Kirkuk, Iraq
     

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Pregnant women could be at risk of developing complications in genital tract when infected with the bacteria Ureaplasma urealyticum. The objective of this study was to assess the impact of genital infection in pregnant women, in Kirkuk city, relevant to both gestational age and level of Interleukine (IL-1α). Fifty five pregnant women were involved whose ages ranged between 18-45 years. Double swab samples from cervix were collected i.e. the first swab used to detect U. urealyticum while the second to assess the level of IL-1α cytokine. Only 45% of pregnant women were infected with U. urealyticum, with the highest positive U. urealyticum infection among age group (18-31 years) (40%), while the older women had less infection frequency (5%). The significantly highest (p≤0.05) distribution percentage was amongst third trimester gestation (33%). Genital expression of IL-1-α had significantly (p≤0.05)elevated during the infection (189±3.3pg/mL) in comparison with non-infected pregnant women. The level of IL-1α was elevated significantly(p≤0.05) among women in third trimester of pregnancy in comparison with second and first trimester, respectively. A significant correlation between U. urealyticum infection and elevationin the level of IL-1αis established.

Keywords

Bacteria Ureaplasma urealyticum, Gestational age,interleukine IL-1α, pregnant women.
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  • Impact of Cervical Infection with Bacteria Ureaplasma Urealyticum to Interleukin-1α-Expression in Pregnant Women

Abstract Views: 96  |  PDF Views: 0

Authors

Aimen A. Ahmed
Directorate of Health, Kirkuk, Clinical Laboratory, Directorate of Health, Baghdad Road, Iraq
Sabah M. Salih
Faculty of Nursury, Assistant Professor, Vice Dean of Faculty of Pharmacy, University of Kirkuk, Iraq
Ayoub A. Bazzaz
Department of Anatomy, Faculty of Veterinary Medicine, University of Kirkuk, Iraq

Abstract


Pregnant women could be at risk of developing complications in genital tract when infected with the bacteria Ureaplasma urealyticum. The objective of this study was to assess the impact of genital infection in pregnant women, in Kirkuk city, relevant to both gestational age and level of Interleukine (IL-1α). Fifty five pregnant women were involved whose ages ranged between 18-45 years. Double swab samples from cervix were collected i.e. the first swab used to detect U. urealyticum while the second to assess the level of IL-1α cytokine. Only 45% of pregnant women were infected with U. urealyticum, with the highest positive U. urealyticum infection among age group (18-31 years) (40%), while the older women had less infection frequency (5%). The significantly highest (p≤0.05) distribution percentage was amongst third trimester gestation (33%). Genital expression of IL-1-α had significantly (p≤0.05)elevated during the infection (189±3.3pg/mL) in comparison with non-infected pregnant women. The level of IL-1α was elevated significantly(p≤0.05) among women in third trimester of pregnancy in comparison with second and first trimester, respectively. A significant correlation between U. urealyticum infection and elevationin the level of IL-1αis established.

Keywords


Bacteria Ureaplasma urealyticum, Gestational age,interleukine IL-1α, pregnant women.



DOI: https://doi.org/10.37506/v11%2Fi2%2F2020%2Fijphrd%2F194949