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Actions of Riluzole on Glast and GLT1 Transporters in Rat Migraine Model


Affiliations
1 Research Scholar cum Assistant professor, Department of Anatomy, Madha Medical College, Bharath Institute of Higher Education and Research, Chennai, Tamilnadu, India
2 Associate Professor, Department of Anatomy, AIIMS, Mangalagiri, India
3 Professor & Head, Department of Anatomy, Saveetha Medical College, Chennai, Department of Anatomy, AIIMS, Mangalagiri, India
4 Associate Professor, Department of Anatomy, AIIMS, Mangalagiri, India
     

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Riluzole exerts a neuroprotective effect through different mechanisms including action on glutamatergic transmission. We investigated whether this drug affect glutamate transporter mediated uptake expressing the rat glutamate transporters GLAST, GLT. We found that riluzole significantly increased glutamate uptake in a dose-dependent manner. This may facilitate the buffering of excessive extra cellular glutamate under pathological conditions suggesting that riluzole’s neuroprotective action might be mediated by its activating effect on glutamate uptake.

Keywords

Riluzole, Glutamate transporters, neuroprotective.
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  • Actions of Riluzole on Glast and GLT1 Transporters in Rat Migraine Model

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Authors

T. Jeevapriya
Research Scholar cum Assistant professor, Department of Anatomy, Madha Medical College, Bharath Institute of Higher Education and Research, Chennai, Tamilnadu, India
R. Archana
Associate Professor, Department of Anatomy, AIIMS, Mangalagiri, India
Gunapriya Raghunath
Professor & Head, Department of Anatomy, Saveetha Medical College, Chennai, Department of Anatomy, AIIMS, Mangalagiri, India
P.K. Sankaran
Associate Professor, Department of Anatomy, AIIMS, Mangalagiri, India

Abstract


Riluzole exerts a neuroprotective effect through different mechanisms including action on glutamatergic transmission. We investigated whether this drug affect glutamate transporter mediated uptake expressing the rat glutamate transporters GLAST, GLT. We found that riluzole significantly increased glutamate uptake in a dose-dependent manner. This may facilitate the buffering of excessive extra cellular glutamate under pathological conditions suggesting that riluzole’s neuroprotective action might be mediated by its activating effect on glutamate uptake.

Keywords


Riluzole, Glutamate transporters, neuroprotective.



DOI: https://doi.org/10.37506/v11%2Fi2%2F2020%2Fijphrd%2F194900