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Current Research in Neuropathology and Pharmacotherapy of Alzheimer’s Disease:A Review


Affiliations
1 Research Scholar, M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India
2 Associate Professor, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India
3 Professor, M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India
4 Research Associate, Department of Pharmacology, All India Institute of Medical sciences, New Delhi, India
5 Professor, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India
     

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Background: Alzheimer’s disease (AD), a category of neurological degeneration generally seen in elderly people which is reflected by memory loss and affecting daily living activities.

Method: The data has been accessed from scopus, pubmed, science-direct and google-scholar which is included in this article. The literature provide the information about pathological alterations of Alzheimer disease emphasizing on formation of neuritic plaques, beta amyloid protein, neurofibrillary tangle and also updates therapeutics used in Alzheimer’s disease including cholinesterase inhibitors, ACE inhibitors, NMDA receptor antagonists, secretase inhibitors and anti-inflammatory drugs, herbal drugs and other naturals.

Results: The research on neuropathology and diagnosis of Alzheimer’s disease are determinants of this study. The pathophysiology, diagnosis using biomarkers and therapeutics of disease has been summarized.

Conclusion: The aim of this review paper is to focus on how diagnosis and pharmacotherapy of Alzheimer’s disease useful for researchers engaged in the experimental research.


Keywords

Alzheimer’s Disease, ±-Amyloid Precursor Protein, Neurofibrillary Tangles, Acetylcholinesterase Inhibitors, Secretase Inhibitors, Biomarkers.
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  • Current Research in Neuropathology and Pharmacotherapy of Alzheimer’s Disease:A Review

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Authors

Amit Yadav
Research Scholar, M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India
Prabhat Kumar Upadhyay
Associate Professor, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India
Manish Kumar
Professor, M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India
Vishal Kumar Vishwakarma
Research Associate, Department of Pharmacology, All India Institute of Medical sciences, New Delhi, India
A. Pandurangan
Professor, M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India
Pradeep Mishra
Professor, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India

Abstract


Background: Alzheimer’s disease (AD), a category of neurological degeneration generally seen in elderly people which is reflected by memory loss and affecting daily living activities.

Method: The data has been accessed from scopus, pubmed, science-direct and google-scholar which is included in this article. The literature provide the information about pathological alterations of Alzheimer disease emphasizing on formation of neuritic plaques, beta amyloid protein, neurofibrillary tangle and also updates therapeutics used in Alzheimer’s disease including cholinesterase inhibitors, ACE inhibitors, NMDA receptor antagonists, secretase inhibitors and anti-inflammatory drugs, herbal drugs and other naturals.

Results: The research on neuropathology and diagnosis of Alzheimer’s disease are determinants of this study. The pathophysiology, diagnosis using biomarkers and therapeutics of disease has been summarized.

Conclusion: The aim of this review paper is to focus on how diagnosis and pharmacotherapy of Alzheimer’s disease useful for researchers engaged in the experimental research.


Keywords


Alzheimer’s Disease, ±-Amyloid Precursor Protein, Neurofibrillary Tangles, Acetylcholinesterase Inhibitors, Secretase Inhibitors, Biomarkers.



DOI: https://doi.org/10.37506/v11%2Fi2%2F2020%2Fijphrd%2F194838