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Analysis and Comparison of Salivary L-Fucose and HSP 70 in Oral Potentially Malignant Disorders and Oral Cancer


Affiliations
1 Lecturer, Nitte (Deemed to be University), A.B. Shetty Memorial Institute of Dental Sciences, Department of Oral Medicine and Radiology, India
2 Professor, Nitte (Deemed to be University), A.B. Shetty Memorial Institute of Dental Sciences, Department of Oral Medicine and Radiology, India
3 Professor, Nitte (Deemed to be University), K.S Hegde Medical Academy, Department of Biochemistry, India
4 Professor, Nitte (Deemed to be University), A.B. Shetty Memorial Institute of Dental Sciences, Department of Orthodontics, India
5 Lecturer, Manipal College of Dental Sciences, Manipal Academy of Higher Education, India
6 Assistant Professor, Ph.D., Scholar, Yenepoya (Deemed to be University), Yenepoya Dental College, Department of Oral Medicine and Radiology, India
7 Research Scholar, Nitte (Deemed to be University), K.S. Hegde Medical Academy, Central Research Laboratory, Mangalore, India
     

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The aim of this study was to assess the level of salivary L-Fucose and Heat Shock Protein 70 in subjects in subjects with Oral Potentially Malignant Disorders and Oral Cancer.\

Method & Results: The study was done among 90 subjects - 30 healthy subjects, 30 subjects with Oral Potentially Malignant Disorders and 30 subjects with Oral Cancer. Saliva samples were collected and the levels of L-Fucose and HSP-70 were determined. Data obtained was analyzed using ANOVA test for the comparison between the groups. Post hoc tukey`s analysis was used for comparing the study groups to the control group.The levels of L-Fucose and HSP-70 in saliva were increased significantly in subjects with Oral potentially malignant disorders and Oral Cancer in comparison to the healthy subjects.

Conclusion: Elevated levels of HSP 70 and L-fucose in saliva in oral potentially malignant disorders and oral cancer indicate their usefulness as biomarkers for early prediction.


Keywords

Saliva, Oral Cancer, HSP 70, L Fucose.
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  • Analysis and Comparison of Salivary L-Fucose and HSP 70 in Oral Potentially Malignant Disorders and Oral Cancer

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Authors

Supriya Bhat
Lecturer, Nitte (Deemed to be University), A.B. Shetty Memorial Institute of Dental Sciences, Department of Oral Medicine and Radiology, India
Gogineni Subhas Babu
Professor, Nitte (Deemed to be University), A.B. Shetty Memorial Institute of Dental Sciences, Department of Oral Medicine and Radiology, India
Suchetha Kumari N.
Professor, Nitte (Deemed to be University), K.S Hegde Medical Academy, Department of Biochemistry, India
K. Saidath
Professor, Nitte (Deemed to be University), A.B. Shetty Memorial Institute of Dental Sciences, Department of Orthodontics, India
Medhini Madi
Lecturer, Manipal College of Dental Sciences, Manipal Academy of Higher Education, India
Sajad Buch
Assistant Professor, Ph.D., Scholar, Yenepoya (Deemed to be University), Yenepoya Dental College, Department of Oral Medicine and Radiology, India
Harshini Ullal
Research Scholar, Nitte (Deemed to be University), K.S. Hegde Medical Academy, Central Research Laboratory, Mangalore, India

Abstract


The aim of this study was to assess the level of salivary L-Fucose and Heat Shock Protein 70 in subjects in subjects with Oral Potentially Malignant Disorders and Oral Cancer.\

Method & Results: The study was done among 90 subjects - 30 healthy subjects, 30 subjects with Oral Potentially Malignant Disorders and 30 subjects with Oral Cancer. Saliva samples were collected and the levels of L-Fucose and HSP-70 were determined. Data obtained was analyzed using ANOVA test for the comparison between the groups. Post hoc tukey`s analysis was used for comparing the study groups to the control group.The levels of L-Fucose and HSP-70 in saliva were increased significantly in subjects with Oral potentially malignant disorders and Oral Cancer in comparison to the healthy subjects.

Conclusion: Elevated levels of HSP 70 and L-fucose in saliva in oral potentially malignant disorders and oral cancer indicate their usefulness as biomarkers for early prediction.


Keywords


Saliva, Oral Cancer, HSP 70, L Fucose.



DOI: https://doi.org/10.37506/v11%2Fi2%2F2020%2Fijphrd%2F194746