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In Vitro Anticancer Study of Bioactive Compound Isolated from Musa Extract (Musa acuminata)


Affiliations
1 Associate Professor, Molecular Diagnostics and Bacterial Pathogenomics Research Laboratory, Department of Biotechnology, Bannari Amman Institute Technology, Sathyamangalam, Erode District, Tamil Nadu, India
2 Research Associate cum Assistant Professor, Molecular Diagnostics and Bacterial Pathogenomics Research Laboratory, Department of Biotechnology, Bannari Amman Institute Technology, Sathyamangalam, Erode District, Tamil Nadu, India
3 III Year Biotech Students, Molecular Diagnostics and Bacterial Pathogenomics Research Laboratory, Department of Biotechnology, Bannari Amman Institute Technology, Sathyamangalam, Erode District, Tamil Nadu, India
     

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Banana tree being one of the most economically important tree worldwide is cut once the fruits are harvested. However other parts of the tree are used in medicine worldwide. In this study, the flower extract of Musa acuminatais extracted by maceration with methanol and the phenolic and aliphatic compounds present in the flower extract is identified using GC-MS analysis. Phytochemical screening of the banana extract showed the presence of alkaloids, phlobatanning, triterpanoids, flavanoids, lipids, steroids and terpenoids. Potent antibacterial activity is observed from the flower extract against the tested gram positive and negative bacteria. Anticancer activity of the flower extract is assessed on the cervical cancer cell line HeLa. MTT assay is used to evaluate the antiproliferative effects. This study concluded that the economically important Musa acuminatais widely used in anticancer studies worldwide.

Keywords

Musa acuminata, Phenolic Compounds, GC-MS Analysis, Phytochemical Screening, Antibacterial Activity, MTT Assay.
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  • In Vitro Anticancer Study of Bioactive Compound Isolated from Musa Extract (Musa acuminata)

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Authors

Arunava Das
Associate Professor, Molecular Diagnostics and Bacterial Pathogenomics Research Laboratory, Department of Biotechnology, Bannari Amman Institute Technology, Sathyamangalam, Erode District, Tamil Nadu, India
J. Bindhu
Research Associate cum Assistant Professor, Molecular Diagnostics and Bacterial Pathogenomics Research Laboratory, Department of Biotechnology, Bannari Amman Institute Technology, Sathyamangalam, Erode District, Tamil Nadu, India
P. Deepesh
III Year Biotech Students, Molecular Diagnostics and Bacterial Pathogenomics Research Laboratory, Department of Biotechnology, Bannari Amman Institute Technology, Sathyamangalam, Erode District, Tamil Nadu, India
G. Shanmuga Priya
III Year Biotech Students, Molecular Diagnostics and Bacterial Pathogenomics Research Laboratory, Department of Biotechnology, Bannari Amman Institute Technology, Sathyamangalam, Erode District, Tamil Nadu, India
S. Soundariya
III Year Biotech Students, Molecular Diagnostics and Bacterial Pathogenomics Research Laboratory, Department of Biotechnology, Bannari Amman Institute Technology, Sathyamangalam, Erode District, Tamil Nadu, India

Abstract


Banana tree being one of the most economically important tree worldwide is cut once the fruits are harvested. However other parts of the tree are used in medicine worldwide. In this study, the flower extract of Musa acuminatais extracted by maceration with methanol and the phenolic and aliphatic compounds present in the flower extract is identified using GC-MS analysis. Phytochemical screening of the banana extract showed the presence of alkaloids, phlobatanning, triterpanoids, flavanoids, lipids, steroids and terpenoids. Potent antibacterial activity is observed from the flower extract against the tested gram positive and negative bacteria. Anticancer activity of the flower extract is assessed on the cervical cancer cell line HeLa. MTT assay is used to evaluate the antiproliferative effects. This study concluded that the economically important Musa acuminatais widely used in anticancer studies worldwide.

Keywords


Musa acuminata, Phenolic Compounds, GC-MS Analysis, Phytochemical Screening, Antibacterial Activity, MTT Assay.



DOI: https://doi.org/10.37506/v11%2Fi1%2F2020%2Fijphrd%2F193841