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Evaluation of Malondialdehyde, Glutathione Peroxidase and Defensin Levels in Patients with and without Periodontitis


Affiliations
1 Graduate Student, Department of Biochemistry, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, India
2 Reader, Department of Biochemistry, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, India
3 Assistant Professor, Department of Biochemistry, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, India
     

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Aim: Aim of the study is to estimate the levels of Malondialdehyde, glutathione peroxidase and Defensin levels on patients with and without periodontitis.

Materials and Method: The levels of Malondialdehyde and Glutathione peroxidase was estimated using colorimetric estimation and Defensin was estimated using ELISA.

Results: Levels of Defensin is increased in patients with periodontitis 9.18+-1.72 when compared to healthy subjects 6.22+-2.73. The mean levels of MDA is increased in patients with periodontitis 2.35+-0.32 when compared to normal patients 3.58+-0.36. The levels of Gpx is lower in patients with periodontitis 2.52+-0.58 when compared to normal patients 3.58+-0.36. The p-value was found to be significant (0.001).

Conclusion: Thus, this study reveals that Malondialdehyde, Defensin and glutathione peroxidase can be considered as biomarkers in the periodontal diseases.


Keywords

Periodontitis, Oxidative Stress, Inflammation, Saliva, Tooth.
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  • Evaluation of Malondialdehyde, Glutathione Peroxidase and Defensin Levels in Patients with and without Periodontitis

Abstract Views: 37  |  PDF Views: 0

Authors

J. Hemashree
Graduate Student, Department of Biochemistry, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, India
Sreedevi Dharman
Reader, Department of Biochemistry, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, India
Selvaraj
Assistant Professor, Department of Biochemistry, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, India

Abstract


Aim: Aim of the study is to estimate the levels of Malondialdehyde, glutathione peroxidase and Defensin levels on patients with and without periodontitis.

Materials and Method: The levels of Malondialdehyde and Glutathione peroxidase was estimated using colorimetric estimation and Defensin was estimated using ELISA.

Results: Levels of Defensin is increased in patients with periodontitis 9.18+-1.72 when compared to healthy subjects 6.22+-2.73. The mean levels of MDA is increased in patients with periodontitis 2.35+-0.32 when compared to normal patients 3.58+-0.36. The levels of Gpx is lower in patients with periodontitis 2.52+-0.58 when compared to normal patients 3.58+-0.36. The p-value was found to be significant (0.001).

Conclusion: Thus, this study reveals that Malondialdehyde, Defensin and glutathione peroxidase can be considered as biomarkers in the periodontal diseases.


Keywords


Periodontitis, Oxidative Stress, Inflammation, Saliva, Tooth.



DOI: https://doi.org/10.37506/v11%2Fi1%2F2020%2Fijphrd%2F193823