Indian Journal of Public Health Research & Development

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Evaluation of Urinary Iodine and Thyroid Hormone in Hypothyroidism of South Indian Population


Affiliations
1 Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
2 Department of Pediatrics, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
3 Institute of Biochemistry, Madras Medical College & RGH, Chennai, Tamil Nadu, India
4 Department of Human Genetics and Molecular Biology, Bharathiyar University, Coimbatore, Tamil Nadu, India
     

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Aim and objective: The present study was conducted to assess the Urinary iodine excretion levels among hypothyroid patients based on Thyroid profile and to correlate the Urinary iodine excretion with various disorders associated with hypothyroidism.

Method: The study group includes 50 control subjects and 100 clinically proven hypothyroidism patients. Histopathological investigations and thyroid scan were taken for all the patients. They were analyzed for Thyroid hormone profile and the Urinary iodine excretion level was determined by Ammonium persulfate method in spot urine sample.

Results: Free T4, TSH and Urinary iodine concentration (UIC) were measured for both the control and study group (P = 0.00).The mean Free T4, TSH & UIC for control group was 1.71 ng/dl, 1.41μIU/ml & 150.28μg/L and the mean Free T4, TSH & UIC for test group was 0.85ng/dl, 48.38μIU/ml & 233.74μg/L respectively. A significant positive correlation between Free T4, TSH and UIC was found. Increased Urinary iodine excretion (UIE) was observed in patients with Papillary Carcinoma, Thyroiditis and Multinodular goiter.

Conclusion: The findings of the present study reveals that increased excretion of urinary iodine reflects under utilization or impaired iodination by the thyroid gland.


Keywords

Hypothyroidism, Urinary Iodine, Iodine Deficiency Disorders, Goitre.
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  • Evaluation of Urinary Iodine and Thyroid Hormone in Hypothyroidism of South Indian Population

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Authors

V. Sathya
Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
G. Bupesh
Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
S. Vasanth
Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
R. Somasekar
Department of Pediatrics, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
K. Ramadevi
Institute of Biochemistry, Madras Medical College & RGH, Chennai, Tamil Nadu, India
A. Vijayanandh
Department of Human Genetics and Molecular Biology, Bharathiyar University, Coimbatore, Tamil Nadu, India

Abstract


Aim and objective: The present study was conducted to assess the Urinary iodine excretion levels among hypothyroid patients based on Thyroid profile and to correlate the Urinary iodine excretion with various disorders associated with hypothyroidism.

Method: The study group includes 50 control subjects and 100 clinically proven hypothyroidism patients. Histopathological investigations and thyroid scan were taken for all the patients. They were analyzed for Thyroid hormone profile and the Urinary iodine excretion level was determined by Ammonium persulfate method in spot urine sample.

Results: Free T4, TSH and Urinary iodine concentration (UIC) were measured for both the control and study group (P = 0.00).The mean Free T4, TSH & UIC for control group was 1.71 ng/dl, 1.41μIU/ml & 150.28μg/L and the mean Free T4, TSH & UIC for test group was 0.85ng/dl, 48.38μIU/ml & 233.74μg/L respectively. A significant positive correlation between Free T4, TSH and UIC was found. Increased Urinary iodine excretion (UIE) was observed in patients with Papillary Carcinoma, Thyroiditis and Multinodular goiter.

Conclusion: The findings of the present study reveals that increased excretion of urinary iodine reflects under utilization or impaired iodination by the thyroid gland.


Keywords


Hypothyroidism, Urinary Iodine, Iodine Deficiency Disorders, Goitre.