The Night Hormone “Melatonin” in Implant Dentistry

Melatonin (N-acetyl-5-methoxy tryptamine) is a substance secreted by different organs in vertebrates. Adding up to in performance a part in the circadian cycle of the body, melatonin also plays a significant role as an anti-oxidant, anti-inflammatory, immune-modulatoryspecial effects on human tissues. Melatonin has been playing a very significant role in the dentistry in various roles. Apart from this melatonin also plays a very powerful and a significant role in Oral implant dentistry.Furthermore,melatonin has been observed to improve osseointegration and bone regeneration. Topical management of melatonin has a helpful effect on periodontal health and osseointegration and also promotes the curing of tooth extractionsockets by impeding the progression of resorption of bone. It also helps in suppressing the peri-implant microflora too. Melatonin positive regulation of bone formation and homeostasis, in combinationwith the inhibitory effects on bone resorption, highlights the potential use of melatonin as a marker of periodontal and periimplant bone-related diseases. Hence this review is to critically evaluateand summarize the effects of melatonin in the bone metabolism, bone repair and healing till the osseointegration in the field of Implant dentistry.