Central Giant Cell Granuloma:Contradicting the Usual Picture

Jaffe in 1953 differentiated Central Giant Cell Granuloma (CGCG) from Giant Cell Tumor of bone. This intra-osseous lesion has been described by various authors’ as a reactive lesion or as a developmental anomaly or as a non neo-plastic lesion. Though inflammation, haemorrhage, local trauma has been suggested as some of the aetiological factors but actual aetiology is still unclear. Genetic aetiology has also been hypothesized. Mandible is the common site of occurrence, frequently crossing the midline. Incidences in females are more and less than 30 is the age of occurrence. The clinical behaviour of CGCG ranges from a slowgrowing asymptomatic swelling to an aggressive lesion with pain, local osteolysis, ischolar_main resorption and tooth displacement. Most widely accepted treatment is surgery. Nonsurgical treatments with alpha-interferon, calcitonin and corticosteroids have been described and their benefits may be worthy of consideration. Contrary to the age, gender and site here we present a case of CGCG in a 52-year-old male patient presenting with a swelling in the right anterior maxilla.