Indian Journal of Public Health Research & Development

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Neurogenic Switching Mechanism: Probable Link between Periodontal Disease and Systemic Diseases:A Review


Affiliations
1 Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India
2 Department of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India
     

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Prevalence of systemic diseases by virtue of dental infections, has been widely recognized and accepted by the dental professionals today. In recent times spread of inflammation via neurogenic switching mechanism has found an interest among researchers and reviewers. Neurogenic switching results from the coaction of mast cells and nerves leading to the spread of inflammation from one site of the body to a distant site. Porphyromonas gingivalis, a principle bacterium triggering periodontal disease releases an endotoxin, lipopolysaccharide, which has been found to induce neurogenic switching mechanism, leading to an exacerbation of symptoms of various systemic diseases. Lowering in the microbial count of dental plaque, has shown to recuperate manifestation of various neurological, cardiovascular, respiratory and pregnancy induced conditions. The purpose of this review is to explore the probable link between various systemic diseases and periodontal disease through neurogenic switching mechanism.

Keywords

Neurogenic inflammation, Immunogenic inflammation, Neuropeptides, Substance P, Neurogenic Switching Mechanism, Periodontitis.
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  • Neurogenic Switching Mechanism: Probable Link between Periodontal Disease and Systemic Diseases:A Review

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Authors

Shristi Shankar
Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India
Rinkee Mohanty
Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India
Anurag Satpathy
Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India
Rashmita Nayak
Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India
Manoj Kumar
Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India
Gatha Mohanty
Department of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India

Abstract


Prevalence of systemic diseases by virtue of dental infections, has been widely recognized and accepted by the dental professionals today. In recent times spread of inflammation via neurogenic switching mechanism has found an interest among researchers and reviewers. Neurogenic switching results from the coaction of mast cells and nerves leading to the spread of inflammation from one site of the body to a distant site. Porphyromonas gingivalis, a principle bacterium triggering periodontal disease releases an endotoxin, lipopolysaccharide, which has been found to induce neurogenic switching mechanism, leading to an exacerbation of symptoms of various systemic diseases. Lowering in the microbial count of dental plaque, has shown to recuperate manifestation of various neurological, cardiovascular, respiratory and pregnancy induced conditions. The purpose of this review is to explore the probable link between various systemic diseases and periodontal disease through neurogenic switching mechanism.

Keywords


Neurogenic inflammation, Immunogenic inflammation, Neuropeptides, Substance P, Neurogenic Switching Mechanism, Periodontitis.