Malignant Hyperthermia:A Systematic Review

Background: Malignant hyperthermia (MH) is a potentially fatal pharmacogenetic disorder of the skeletal muscles that presents as a hypermetabolic response to potent inhalational anaesthetic agents such as halothane, sevoflurane, desflurane, isoflurane and the depolarizing muscle relaxants like succinylcholine, and rarely, due to vigorous exercise and heat.

Method: A systematic review was carried out using the database PubMed central and MEDLINE using the keywords General anaesthesia, malignant hyperthermia, systematic review. This literature search yielded 1174 articles published up to the year 2018. INCLUSION CRITERIA: peer reviewed retrospective and prospective cohort studies, cross sectional studies, case descriptions were included in the study.

Objective: The objective of this systematic review is to provide a wide and objective assessment of the incidence of Malignant Hyperthermia in patients undergoing surgery with or without general anaesthesia