Effect of CPP ACP and Nano Hydroxyapatite Incorporated GIC on Remineralization of Dentin

The objective of this invitro study was to investigate, whether the remineralization potential of conventional GIC in human dentin could be improved by combining with CPP - ACP and nano hydroxyapatite. Class I cavities were prepared in sound human extracted third molars and they were randomly assigned to 3 groups according to the restorative materials. Group I: Conventional GIC, Group II:Conventional GIC and CPP-ACPand Group III: Conventional GIC powder & Nano hydroxy apatite. The samples were subjected to remineralizationand demineralization cycles for period of 2 weeks. Energy dispersive X-ray analysis was used to evaluate the remineralization. The elemental compositions were analyzed using One way ANOVA, Post Hoc and Mann Whitney tests. The calcium and phosphate concentration were statistically significantly greater in Group III than Group I and II (P<0.05).Nanohydroxy apatite with GIC remineralized the demineralized dentin almost equal to normal dentin.

Clinical Relevance: GIC with nanohydroxy apatite might be superior restorative/base with an improved remineralization potential of dentin.