Histological Studies on Pancreatic Tissue in High Fat Diet with Low Multiple Dosage of Streptozotocin Induced Type 2 Diabetes After Gymnema Sylvestre Administration

gymnemasylvestre is a medicinal plant for the potential management of diabetes mellitus. The leaves are used in herbal medicinal preparation. phytochemical study shows its therapeutic value and for treating the patient with type 2 diabetes mellitus⁽¹¹⁾.The present study deals with the ethanolic extraction from powdered leaves of gymnemasylvestre through the soxhlet apparatus carried out for 48 hours.the active phytochemical component of gymnemagenin and its antidiabetic and hypolipedemic property⁽⁶⁾ is tested by standard procedure. The chemical test such as thin layer chromatography shows the presence of gymnemicacid. isolation and quantification of the powdered leaves of gymnemasylvestre is revealed the presence of gymnemagenin⁽²⁾. Type 2 diabetes is confirmed with the values of fasting bloog glucose and c-peptide level.The ethanolic extract of gymnemasylvestre⁽¹⁴⁾with dose of 200mg/kg body weight and 400mg/kg is administered to low multiple dose 40mg/kg body weightstreptozotocin induced type 2 diabetes mellitus and the parameters of blood glucose,body weight are taken and it is compared to normal control group.The histopathogical study shows a significant changes in the recovery of pancreatic beta cell in the treatment of gymnemasylvestre⁽⁷⁾.The result indicates the component of gymnemic acid⁽⁵⁾ from gymnema sylvestre is useful in controlling the blood sugar level to treat type 2 diabetes mellitus in the earliest stage of disease.