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Chromosomal Aberrations in Breast Cancer Females


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1 Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah Hills, Bhopal, India
     

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Breast cancer is one of the most prevalent cancers in women and accounts for nearly 23% of all cancers worldwide. It has been increasing at an alarming speed and there is a need to search for new and better diagnostic tools for its early and effective diagnosis. The current diagnostic tools include mammography, MRI, and FNAC. In this regard, cytogenetic analysis of breast cancer using standard Lymphocyte Culture Technique 1 can be proved as a powerful and cost-effective tool to identify women with high risk of developing Breast Cancer. The technique can be used to study the altered chromosomal pattern in terms of its number or structure owing to its diseased condition that might be specific to Breast Cancer. In the present study, peripheral blood from breast cancer as well as healthy females were taken and subjected to cytogenetic analysis and studying their structural and numerical aberrations. The breast cancer patients were found to be having higher frequency of aberrations than healthy control.
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  • Chromosomal Aberrations in Breast Cancer Females

Abstract Views: 260  |  PDF Views: 0

Authors

N. Ganesh
Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah Hills, Bhopal, India
Alibha Rawat
Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah Hills, Bhopal, India

Abstract


Breast cancer is one of the most prevalent cancers in women and accounts for nearly 23% of all cancers worldwide. It has been increasing at an alarming speed and there is a need to search for new and better diagnostic tools for its early and effective diagnosis. The current diagnostic tools include mammography, MRI, and FNAC. In this regard, cytogenetic analysis of breast cancer using standard Lymphocyte Culture Technique 1 can be proved as a powerful and cost-effective tool to identify women with high risk of developing Breast Cancer. The technique can be used to study the altered chromosomal pattern in terms of its number or structure owing to its diseased condition that might be specific to Breast Cancer. In the present study, peripheral blood from breast cancer as well as healthy females were taken and subjected to cytogenetic analysis and studying their structural and numerical aberrations. The breast cancer patients were found to be having higher frequency of aberrations than healthy control.


DOI: https://doi.org/10.37506/v10%2Fi12%2F2019%2Fijphrd%2F192038