Indian Journal of Health and Wellbeing

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Study of Various Liver Function Oxidative Stress Antioxidant Status in Malnourished Children


Affiliations
1 Department of Biochemistry, Pacific Medical College & Hospital, Udaipur, Rajasthan, India
     

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Malnutrition is a condition where physical function o f a person is not proper to the point where he can no longer maintain adequate body performance processes. In this respect few studies have been carried so the present study aims to evaluate biochemical markers in young patients suffering from malnutrition. We have evaluated liver function test, CRP as a marker, oxidative stress marker- MDA, antioxidant Ascorbic Acid and Zinc and also correlated with above parameter in severe acute malnutrition. Among 120 subjects, 25 cases + 25 controls were males and 35 cases + 35 controls were females. Biosystems a- 25 fully automated analyzer was used for measurement. A significant negative correlation was between MDA and Total protein and Albumin. A significant positive correlation was between MDA and AST and ALT. A significant negative correlation was seen in levels of ascorbic acid and Zinc and CRP, MDA level was significantly higher while vitamin C, Zinc are significantly low in malnourished children (p< 0.001) results o f our present work provide evidence that oxidative stress is present in sever e malnourished children along with inflammation and hepatic damage Extent o f derangement o f parameters can help to plan specific treatment for malnourished children.

Keywords

Malnutrition, Biochemical Markers, Young Patients.
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  • A Manual: Measuring and interpreting Malnutrition and Mortality. Available at:http://www.unhcr.org/45f6abc92.pdf

  • Bosnak, M.,Kelekci, S.,Yel, S.,Kocyigit,Y., Sen,V.,&Ece,A. (2008). Oxidative stress in marasmic children. Relationships with Leptin. European Journal o f General Medicine, 7(1), 1-8.

  • Chiasera, J.M, & X, X. (2009). Livefi- function. In M.L. Bishop, E.P. Fody, and L.E. Schoeff (Eds.), Clinical chemistry-techniques, principles, correlations (6th ed., p. 528). New Delhi: Wolters Kluver.

  • Jain, A., Varma, M., Agrawal, B.K., & Jadhav, A.A. (2008). Estimation ofserum zinc and alkaline phosphatase in malnutrition children. Current Pediatric Research, 72(1-2), 27-30.

  • Khare, M., Mohanty, C.,Das,B. K., Jyoti, A., Mukhopadhyay, B., &Mishra, S. P. (2014). Free radicals and antioxidant status in protein energy malnutrition. International Journal o f Pediatrics, Vol. 6. doi: 10.1155/2014/254396.

  • Kumar, S.G.R., Sujatha, R.W., Delphine, S.C.R., & Shwetha, K. (2011). Plasma zinc levels in children with malnutrition and pneumonia: A comparative study. International Journal o f Chemical and Pharmaceutical Research, 2(7), 182-187.

  • Who (2002). Malnutrition the global picture. Geneva: World Health Organization. Available at http//www.who.int/home-page/

  • Who Child Growth Standards & the Identification of severe Acute Malnutrition in Infants & Children (2009). Ajoint Statement by the World Health Organization and the United Nations Children's Fund. Available at: http//www.who.int/nutrition/ publications/severemalnutrition/9789241598163/en/index.html


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  • Study of Various Liver Function Oxidative Stress Antioxidant Status in Malnourished Children

Abstract Views: 241  |  PDF Views: 1

Authors

Nita Sahi
Department of Biochemistry, Pacific Medical College & Hospital, Udaipur, Rajasthan, India
Nisha Tripathi
Department of Biochemistry, Pacific Medical College & Hospital, Udaipur, Rajasthan, India

Abstract


Malnutrition is a condition where physical function o f a person is not proper to the point where he can no longer maintain adequate body performance processes. In this respect few studies have been carried so the present study aims to evaluate biochemical markers in young patients suffering from malnutrition. We have evaluated liver function test, CRP as a marker, oxidative stress marker- MDA, antioxidant Ascorbic Acid and Zinc and also correlated with above parameter in severe acute malnutrition. Among 120 subjects, 25 cases + 25 controls were males and 35 cases + 35 controls were females. Biosystems a- 25 fully automated analyzer was used for measurement. A significant negative correlation was between MDA and Total protein and Albumin. A significant positive correlation was between MDA and AST and ALT. A significant negative correlation was seen in levels of ascorbic acid and Zinc and CRP, MDA level was significantly higher while vitamin C, Zinc are significantly low in malnourished children (p< 0.001) results o f our present work provide evidence that oxidative stress is present in sever e malnourished children along with inflammation and hepatic damage Extent o f derangement o f parameters can help to plan specific treatment for malnourished children.

Keywords


Malnutrition, Biochemical Markers, Young Patients.

References