Indian Journal of Health and Wellbeing

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Study of Serum Osteocalcin and Serum Adiponectin in Young Healthy Offspring of Diabetic Parents


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1 Department of Biochemistry, Pacific Medical College & Hospital, Udaipur, Rajasthan, India
     

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With the increasing prevalence of diabetes all over the world, it is required to understand the relation between serum osteocalcin, Adiponectin and measurement o f glucose, insulin level in off-spring o f diabetic patient, also correlating measure o f insulin resistance. We have also compared serum osteocalcin level and adiponectin level in young healthy offspring o f diabetic with offspring o f healthy parents .our study was carried in department of biochemistry Pacific Medical College And Hospital Udaipur .the conclusion drawn was that serum adiponectin was significantly loe in person who are at genetically high risk for diabetes and serum osteocalcin was inversely correlation o f adiponectin was with blood glucose and insulin .our study exhibit its probable role in future onset of diabetes in such individual.

Keywords

Serum Osteocalcin, Serum Adiponectin, Diabetic Parents.
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  • Anjana, R.M., Pradeepa, R , Deepa, M., Datta, M., Sudha, V., Unnikrishnan, R , Bhansali, A., Joshi, S.R., Joshi, P.P., Yajnik, C.S., Dhandhania, V.K., Nath, L.M., Das, A .K, Rao, P.V, Madhu, S.V, Shukla, D.K, Kaur, T., Priya, M., Nirmal, E , Parvathi, S.J, Subhashini, S., Subashini, R , Ali, M.K, & Mohan, V. (2011). Studied the prevalence of diabetes andpre- diabetes (impaired fasting glucose & /or impaired glucose tolerance) in urban and rural India and multiple logistic regression analysis showed significant association of diabetes with family history of diabetes along with other risk factors. Diabetologia, 54( 12), 3022-3027. doi:10.1007/s00125-011-2291-5.Epub2011Sep30.

  • Barham, D., & Trinder, P. (1972). Improved color reagent for the determination of blood glucose by the Oxidase system. Analyst, P7(151), 142-145.

  • Bose,K.S.C., Bindra, M., Gupta, S.K., & Vyas, P. (2013). Study on association of serum osteocalcin and adiponection with diabetic markers in genetically high risk for type 2 diabetes populations. British Journal o f Medicine and Medical Research, 5(4), 1087-1096.

  • Diagnosis & Classification of Diabetes Mellitus (2008). American Diabetes Association. Diabetes Care, 31(1), S55- S60. doi: 10.2337/dc08-S055.

  • Ferron, M., Hinoi, E., Karsenty, G., & Ducy, P. (2008). Osteocalcin differentially regulates beta cell and adipocytes gene expression and effects the development of metabolic diseases in wild- type mice. Proceedings o f the National Academy o f Sciences o f the United States o f America, 150,5266-5270.

  • Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., Nishida, M., Kihara, S., Sakai, N., Nakajima, T., Hasegawa, K., Muraguchi, M., Ohmoto, Y., Nakamura, T., Yamashita, 5., Hanafusa, T., & Matsuzawa, Y. (2000). Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arteriosclerosis Thrombosis and Vascular Biology, 20(6), 1595-1599.

  • IDF Diabetes Atlas, 4th edition (2009). International Diabetes Federation. The IDF Diabetes Atlas, fourth edition, therefore aims to highlight the evidence base needed for governments, civil society, international health organizations and the health community to make informed decisions on prevention and care strategies. This edition of the IDF Diabetes Atlas marks a watershed in the prevention and care of diabetes. United Nations Resolution 61/225, adopted unanimously in 2006.

  • Im, J.A., Yu, B.P., Jeon, J.Y., & Kim, S.H. (2008). Relationship between osteocalcin and glucose metabolism in postmenopausal women. Clinica Chimica Acta, 396(1-2), 66-69.

  • Kindblom, J.M., Ohlsson, C., Lijunggren, O., Karlsson, M.K., Tivesten, A., Smith, U., & Mellstrom, D. (2008). Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men. Journal o f Bone and Mineral Research, 24, 785-791.

  • Lihn, A. S., 0stergard, T., Nyholm, B., Pedersen, S.B., Richelsen, B., & Schmitz, O. (2003). Adiponectin expression in adipose tissue is reducedin first- degree relatives of type 2 diabetic patients. American Journal o f Physiology-Endocrinology and Metabolism, 284(2), E443-E448.

  • Lindsay, R.S., Funahashi, T., Hanson, R.L., Matsuzawa, Y., Tanaka, S., Tataranni, P.A., Knowler, W.C., & Krakoff, J. (2002). Adiponection and deyelopment of type 2 diabetes in the Pima Indian population. Lancet, 360(9326), 57-58.

  • Liu, J.M, Zhao, H.Y., Zhao, L , Chen, Y., Zhang, L.Z., Tao, B , Sun, L.H, Zhao, Y.J, Wang, W.Q, Xu, M.Y, Chen, J.L., & Ning, G. (2013). Elisa kit for human osteocalcin/bone gla protein (OT/BGP). QAYEE-BIOforLife Science, 98(5), 2146-2152. doi: 10.1210/jc.2013-1112.Epub2013Apr3.

  • Mi, Z., Xiaojing, M., Huating, L., Xiaoping, P., Junling, T., & Yunchao, G., Xuhong, H., Huijuan, L.,Yuqian, B., & Weiping, J. (2009). Serum osteocalcin concentrations in relation to glucodse and lipid metabolism in Chinese individuals. European Journal o f Endocrinology, 161, 723-729.

  • Pellme, F., Smith, U., Funahashi, T., Matsuzawa, Y., & Brekke, H., Wiklund, O., Taskinen, M.R., & Jansson, P.A. (2003). Circulating adiponectin levels are reduced in non-obese but insulin-resistant first-degree relatives of type 2 diabetic patients. Diabetes, 52(5), 1182-1186.

  • Randle, P.J., Garland, P.B., Hales, C.N., & Newsholme, E.A. (1963). The glucose fattyacid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet, 7(7285), 785-789.

  • Saleem, U., Mosley, T.H.Jr., & Kullo, I.J. (2010). Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(7), 1474-1478.

  • Segovia, B.L., Tinoco, M.G., Arrizon, A.I., Mendoza, J.M.G., & Licona, N.A. (2012). Long term consequencesfor offspring o f paternal diabetes and metabolic syndrome. Hindawi Publishing Corporation Experimental Diabetes Research Volume 2012, Article ID 684562,5 pages.

  • Shahid, A., Lone, K.P., Saeed, S., & Muhammad, A. (2008). Male offspring of both diabetic parents have higher insulin resistance and serum Leptin levels compared to those with one diabetic parent. Hormones, 7(4), 313-319.

  • Shulman, G.I. (2000). Cellular mechanism ofinsulinresistance. The Journal o f Clinical Investigation, 706(2), 171-176.

  • Starr, J.I., Mako, M.E., Juhn, D., & Rubenstein, A.H. (1978). Measurement of serum proinsulin like material: Cross reactivity of procine and human proinsulin in the insulin radioimmunoassay. Journal o f Laboratory and Clinical Medicine, 91(A), 683-692.

  • Sull, J.W, Kim, H.J, Yun, J.E, Kim, G., Park, E.J, Kim, S., Lee, H.Y, & Jee, S.H. (2009). Serum adiponectin is associated with family history of diabetes independently of obesity and insulin resistance in healthy Korean men and women. European Journal o f Endocrinology, 160(1), 39-43.

  • Temple, R.C., Clark, P.M., & Hales, C.N. (1992). Measurement o f insulin secretion in type 2 Diabetes: problems and pitfalls. First published.

  • Tsao, T.S., Lodish, H.F., & Fruebis, J. (2002). ACRP30, a new hormone controlling fat and glucose metabolism. European Journal o f Pharmacology, 440(30), 213-221.

  • Yokota, T., Oritani, K., Takahashi, I., Ishikawa, J., Matsuyama, A., Ouchi, N., Kihara, S., Funahashi, T., Tenner, A.J., Tomiyama, Y., & Matsuzawa, Y. (2000). Adiponectin, a new member of the family of soluble defence collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages.Blood, 96(5), 1723-1732.


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  • Study of Serum Osteocalcin and Serum Adiponectin in Young Healthy Offspring of Diabetic Parents

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Authors

Nita Sahi
Department of Biochemistry, Pacific Medical College & Hospital, Udaipur, Rajasthan, India
Reena Nayak
Department of Biochemistry, Pacific Medical College & Hospital, Udaipur, Rajasthan, India

Abstract


With the increasing prevalence of diabetes all over the world, it is required to understand the relation between serum osteocalcin, Adiponectin and measurement o f glucose, insulin level in off-spring o f diabetic patient, also correlating measure o f insulin resistance. We have also compared serum osteocalcin level and adiponectin level in young healthy offspring o f diabetic with offspring o f healthy parents .our study was carried in department of biochemistry Pacific Medical College And Hospital Udaipur .the conclusion drawn was that serum adiponectin was significantly loe in person who are at genetically high risk for diabetes and serum osteocalcin was inversely correlation o f adiponectin was with blood glucose and insulin .our study exhibit its probable role in future onset of diabetes in such individual.

Keywords


Serum Osteocalcin, Serum Adiponectin, Diabetic Parents.

References