Indian Journal of Health and Wellbeing

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Recent Advances in Management of Giant Cell Tumor


Affiliations
1 Department of Orthopaedics and Joint Replacement Surgery, Indraprastha Apollo Hospitals, New Delhi, India
2 Department of Ophthalmology, BPS Medical College, Sonipat, India
3 Department of Radiodiagnosis, Regional Diagnostic Center, BPS Medical College, Khanpur Kalan, Sonipat, Haryana, India
4 Department of Pediatrics, B.D. Sharma, PGIMS, Rohtak, India
     

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Giant cell tumor (GCT) was first described by cooper and Traver in 1818. More prevalent in India and China constituting around twenty present of all bone tumors with a female preponderance. GCT of bone is characteristically homogeneous pale brown, firm though friable associated with secondary haemorrhagic changes. The presence of Multinucleated Giant cell along with mononuclear spindle shaped stromal cells is pathognomic. On a radiograph, they are characterised by lytic tumor surrounding with a poorly defined zone of sclerosis often eroding the cortex. They may present as an eccentrically located expansile lesion. Recurrence of the tumor has been noticed and hence long-term follow-up is necessary.

Keywords

Giant Cell Tumor, Radiotherapy, Embolization, Bisphosphonates, Denosumab.
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  • Recent Advances in Management of Giant Cell Tumor

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Authors

Virender Kumar
Department of Orthopaedics and Joint Replacement Surgery, Indraprastha Apollo Hospitals, New Delhi, India
Ruchi Dabasd
Department of Ophthalmology, BPS Medical College, Sonipat, India
Mamta Singhroha
Department of Radiodiagnosis, Regional Diagnostic Center, BPS Medical College, Khanpur Kalan, Sonipat, Haryana, India
Mahesh Kumar
Department of Pediatrics, B.D. Sharma, PGIMS, Rohtak, India

Abstract


Giant cell tumor (GCT) was first described by cooper and Traver in 1818. More prevalent in India and China constituting around twenty present of all bone tumors with a female preponderance. GCT of bone is characteristically homogeneous pale brown, firm though friable associated with secondary haemorrhagic changes. The presence of Multinucleated Giant cell along with mononuclear spindle shaped stromal cells is pathognomic. On a radiograph, they are characterised by lytic tumor surrounding with a poorly defined zone of sclerosis often eroding the cortex. They may present as an eccentrically located expansile lesion. Recurrence of the tumor has been noticed and hence long-term follow-up is necessary.

Keywords


Giant Cell Tumor, Radiotherapy, Embolization, Bisphosphonates, Denosumab.