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Rai, Yogesh Kumar
- A Study of Protective effect of Ginger (Zingiber Officinale) in Normal and Carbon-Tetrachloride Induced Hepatotoxic Rats in Western U.P. India
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Authors
Affiliations
1 Department of Medicine, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
2 Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
3 Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
1 Department of Medicine, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
2 Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
3 Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
Source
Indian Journal of Forensic Medicine & Toxicology, Vol 7, No 2 (2013), Pagination: 64-67Abstract
The current study has been conducted to investigate the affect of ginger on hepatic antioxidant enzymes system in carbon tetrachloride induced hepatotoxic rats. The first set of animals received only ginger-supplemented diet while the another set were treated with CCl4 before maintaining them on ginger-based diets.Consumption of the experimental diets by the normal rats produced significant elevation (p<0.05) in the activities of the hepatic aspartate aminotransferase and alanine aminotransferase as well as the concentration of protein and albumin. Administration of CCl4 to the second set of rats resulted in the alteration of the liver function parameters . However, the significantly reduced (p<0.05) marker enzymes such as AST, ALT, due to CCl4 treatment were restored towards normalization on consumption of ginger diet. The biochemical parameters like total protein and albumin were also restored towards normal levels. The findings indicate that the ginger is an efficient hepatoprotective and antioxidant agent against CCl4-induced liver toxicity.Keywords
Aminotransferases, Carbon tetrachloride (CCl4), De novo synthesis Hepatotoxicity, Spices
References
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- Valproate-induced Subclinical Hypothyroidism
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Authors
Affiliations
1 Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, U.P., IN
2 Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, U.P., IN
3 Department of Obstetrics & Gynecology, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, U.P., IN
1 Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, U.P., IN
2 Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, U.P., IN
3 Department of Obstetrics & Gynecology, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, U.P., IN
Source
Indian Journal of Forensic Medicine & Toxicology, Vol 5, No 1 (2011), Pagination: 110-112Abstract
Introduction:
Sodium valproate (VPA) is widely used for the treatment of partial and generalized epilepsy in childhood and adolescence. The results of the studies that have evaluated the effect of VPA monotherapy on thyroid function in epileptic patients are controversial.
Objective:
Studies on the effects of sodium valproate on thyroid hormone balance in patients with epilepsy are conflicting. The aim of this study was to prospectively evaluate the changes in thyroid profile in epilepsy treated with valproate monotherapy.
Methods:
Serum level of triiodothyronine (T3), thyroxin (T4) and thyroid stimulating hormone (TSH) were determined in 40 epileptic patients of valproate monotherapy by EIA method.
Results:
Epileptic patients had slightly decreased triiodothyronine (T3) and thyroxin (T4), whereas TSH level was significantly increased on valproate monotherapy.
Conclusion:
The results showed that valproate may induce subclinical hypothyroidism. This suggests a need for careful monitoring of serum TSH level in epileptic patients receiving valproate drug.
Keywords
Antiepileptic Drugs (AEDS), Epilepsy, Thyroid Hormones, Endocrinological System, Subclinical Hypothyroidism, Valproate (VPA).References
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