Indian Journal of Forensic Medicine & Toxicology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Biochemical Toxicity of Organophosphate Pesticide Metasystox in Fish Channa Punctatus


Affiliations
1 Department of Biochemistry, B.S.D.B.A. Government Medical College, Kannauj, India
2 Department of Biotechnology, BabaSaheb Bhimrao Ambedkar Central University, Lucknow, India
3 Department of Biochemistry, M.G.M. Medical College, Navi Mumbai, India
     

   Subscribe/Renew Journal


Objective: To study the biochemical parameters of serum cholesterol and serum glutamate pyruvate transaminase in fish channa punctatus, exposed under pesticide metasystox.

Materials and Methods: This study was concluded in fish channa punctatus, exposed 24 to 96 hours, to four different concentration of metasystox pesticide. Serum cholesterol and S.G.P.T. levels were estimated as biochemical biomarkers.

Result: There were significantly increase in serum cholesterol (Hypercholesterolemia) and S.G.P.T observed in metasystox pesticide exposed on fish channa punctatus, about at all concentration and time intervals.

Conclusion: The hypercholesterolemia and elevated aminotransferase (S.G.P.T) due to metasystox toxicity referred as biomarkers for the disorder like myocardial infarction, heart attack, hepatitis biliary obstruction, alcoholic cirrhosis, cancer, toxic hepatitis etc, in human beings


Keywords

OPP (Organophosphate Pesticide), SGPT (Serum Glutamate pyruvate Transaminase), Metasystox
Subscription Login to verify subscription
User
Notifications
Font Size


  • Senanayake . n, Johnson R., Acute polyneurophathy after poisoning by a yew organophosphate pesticide. N Engl J Med 1992; 302:155-7.

  • Coppage, D.L; Mathew, E; Cook, G.H. and knight, J.1975 Brain acetylcholinesterase inhibition in as a diagnosis of environmental poisoning by Malathion, o,o-dimethyl-s-(1,2 dicarbethoxy ethyl) phosphorodithioate, pesticide Biochem. Physiology 5:536-542.

  • Johnson MK, Jacobasen D, Meredithtj, EyerP, Heath AJ, Ligtenstein DA etal. The IPCS working group on antidotes for organophosphorous pesticide poisoning, WHO. Evaluation of antidots for poisoning for OP pesticides. Emerg Mel 2000:12:22-37.

  • Malkovics B. Effect of organophosphates on the antioxidant systems of fish tissue. Acta Bio hung 1995; 9;11.

  • A. Gupta,G.S.Shukla; Effects of neonatal quinalphos exposure and subsequent withdrawal on free radical generation and antioxidative defences in developing rat brain, J.Appl. Toxicol.18 (1998) 71-77.

  • F.N.Bebe, M. Panemangalore; pesticides and essential minerals modify endogenous antioxidants and cytochrome P450 in tissue of rats; J.Environ.Sci.Health B40(2005) 769-784.

  • A.P.H.A. (American Public Health Association) 1991: “Standard Methods For The Examination of Water and Waste Water” 14th Ed. American Public Health Association New york.

  • Zlatkis A; Zak B. and Boyle A.J. 1953: J.Lab clin.Med. 41:486-92.

  • Reitman, s., Frankel,s.,1957:A colorimetric method for the determination of serum glutamic oxaloacetic and pyruvic transaminase.Amer.j.clin.Path.28:56-63.

  • Valcazav, A.A.et al; 1990, Arch.pharmacology Toxicol.6, 750

  • King, S.F.1985 in “Environmental Pollution by Pesticides “Ed. C.A.Edwards, Plenom Press, London.

  • Mishra, B.P; Singh, R.K; etal:Biochemical toxicity of organophosphate pesticide sumithion in teleost fish,Heteropneustes fossil. J. Environ. Res; 2000; 10(1):25-26

  • Kaplon, M.A; Cantterburg, J.M; Gavellas, G, Reiss, E. and Brickar, N.S.1978. Adv.Exp.Med.Bio; 103:257-262.

  • Tevashina, Y, Tohrai, N. and Itoh, H.1978: Nippon, Chikusan Gakhaiho, 49:189-194.

  • Mishra B.P; Badade Z.G; S.K. Rastogi 2010: Oxidative stress and antioxidant status in organophosphate poisoning. Indian Journal of Clinical Biochemistry, ICGB Vol:25;137.


Abstract Views: 418

PDF Views: 0




  • Biochemical Toxicity of Organophosphate Pesticide Metasystox in Fish Channa Punctatus

Abstract Views: 418  |  PDF Views: 0

Authors

B. P. Mishra
Department of Biochemistry, B.S.D.B.A. Government Medical College, Kannauj, India
M. Y. Khan
Department of Biotechnology, BabaSaheb Bhimrao Ambedkar Central University, Lucknow, India
Z. G. Badade
Department of Biochemistry, M.G.M. Medical College, Navi Mumbai, India
M. Chandravathi
Department of Biochemistry, M.G.M. Medical College, Navi Mumbai, India
Deepak
Department of Biochemistry, B.S.D.B.A. Government Medical College, Kannauj, India

Abstract


Objective: To study the biochemical parameters of serum cholesterol and serum glutamate pyruvate transaminase in fish channa punctatus, exposed under pesticide metasystox.

Materials and Methods: This study was concluded in fish channa punctatus, exposed 24 to 96 hours, to four different concentration of metasystox pesticide. Serum cholesterol and S.G.P.T. levels were estimated as biochemical biomarkers.

Result: There were significantly increase in serum cholesterol (Hypercholesterolemia) and S.G.P.T observed in metasystox pesticide exposed on fish channa punctatus, about at all concentration and time intervals.

Conclusion: The hypercholesterolemia and elevated aminotransferase (S.G.P.T) due to metasystox toxicity referred as biomarkers for the disorder like myocardial infarction, heart attack, hepatitis biliary obstruction, alcoholic cirrhosis, cancer, toxic hepatitis etc, in human beings


Keywords


OPP (Organophosphate Pesticide), SGPT (Serum Glutamate pyruvate Transaminase), Metasystox

References