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Synthesis, Characterization of New Tris Hydrazones based on Cyanuric Acid and Studies the Biological Activity as Antibacterial and Antifungal


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1 Directorate of Education Dhi Qar, Ministry of Education, Iraq
     

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In this study synthesis of new Tris Hydrazones derived from Cyanuric acid , these compounds synthesized by reaction of Cyanuric acid with Chloro ethyl acetate to product [I], then converted it to acid Hydrazide [II] by reacted with Hydrazine hydrate(80%) in absolute ethanol as a solvent. Compound [II] refluxed with different aromatic aldehyde in present of Glacial acetic acid (GAA) as a catalyst to formation new Tris Hydrazones [III]a-f. All new compounds were synthesized characterization by FT-IR and 1H-13CNMR spectroscopy. The biological activity of new Tris Hydrazones studies against to positive and negative Gram bacteria also test it against to Candida albicans as a sample of Fungi.

Keywords

Cyanuric acid, Hydrazones, antibacterial, 1,3,5-Triazinane-2,4,6-trione, antifungal
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  • Synthesis, Characterization of New Tris Hydrazones based on Cyanuric Acid and Studies the Biological Activity as Antibacterial and Antifungal

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Authors

Thaer Saleh Ghali
Directorate of Education Dhi Qar, Ministry of Education, Iraq

Abstract


In this study synthesis of new Tris Hydrazones derived from Cyanuric acid , these compounds synthesized by reaction of Cyanuric acid with Chloro ethyl acetate to product [I], then converted it to acid Hydrazide [II] by reacted with Hydrazine hydrate(80%) in absolute ethanol as a solvent. Compound [II] refluxed with different aromatic aldehyde in present of Glacial acetic acid (GAA) as a catalyst to formation new Tris Hydrazones [III]a-f. All new compounds were synthesized characterization by FT-IR and 1H-13CNMR spectroscopy. The biological activity of new Tris Hydrazones studies against to positive and negative Gram bacteria also test it against to Candida albicans as a sample of Fungi.

Keywords


Cyanuric acid, Hydrazones, antibacterial, 1,3,5-Triazinane-2,4,6-trione, antifungal



DOI: https://doi.org/10.37506/v14%2Fi1%2F2020%2Fijfmt%2F192993