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The Incidence of Contrast Induced Nephropathy-Acute Kidney Injury after cardiac catheterization in Basra Cardiac Catheterization Center. A Prospective Cohort Study


Affiliations
1 College of Pharmacy/University of Baghdad, Baghdad, Iraq
2 Al-Sader Teaching Hospital, Basra, Iraq
3 College of Medicine/University of Basra, Basra, Iraq
4 Basra Cardiac Catheterization Center, Basra, Iraq
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Introduction: Patients who opt for coronary interventions to help them with their IHD problems face several adverse reactions; the most frequently faced is acute kidney injury from contrast media exposure or contrast induced nephropathy. Those patients have higher mortality and morbidity both in the short and longterm period. The incidence of this adverse reaction in Al-Basra Cardia Center is poorly studied so far. We measured the incidence of AKI in this center and tried to correlate the risk with some important covariates identified by previous researches. Method: this was an observational prospective study. It was a part of the double blind single center study (the effect of spironolactone on the incidence of AKI in patients with Stable IHD admitted for coronary intervention, trial registration: ClinicalTrials.gov NCT03329443). Results: The overall incidence of CIN was 20.2% in this cohort sample. Priori defined high risk variables were tested in univariate logistic regression, and if found to be significant they were to be added to a Multi-Logistic regression model analysis. In Regression analysis only GFR (Log Odds ratio) [0.984 (0.971-0.998)] and Mehran Risk score [Mehran >6 (2.456(1.335-4.519), Mehran >11 (3.931) Mehran >16 (12.366) compared to Mehran <5) were positive in the model analysis. Conclusion: there seems to be a high incidence of AKI in this cohort. Important significant factors include low GFR and a good correlation with Mehran risk score.

Keywords

AKI, Acute Kidney Injury, CIN, Contrast Induced Nephropathy, Angiography, PCI, Percutaneous Coronary Intervention, IHD, Ischemic Heart Disease, CI-AKI, Mehran risk score
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  • The Incidence of Contrast Induced Nephropathy-Acute Kidney Injury after cardiac catheterization in Basra Cardiac Catheterization Center. A Prospective Cohort Study

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Authors

Alhasan Mujtaba
College of Pharmacy/University of Baghdad, Baghdad, Iraq
Mohammed Abbas Taher
College of Pharmacy/University of Baghdad, Baghdad, Iraq
Hayder Kadhum AlRubay
Al-Sader Teaching Hospital, Basra, Iraq
Mazin Abed Hazza
College of Medicine/University of Basra, Basra, Iraq
Hasan Mohammed AlRubaye
Basra Cardiac Catheterization Center, Basra, Iraq
Hamid AbdulWahab
Basra Cardiac Catheterization Center, Basra, Iraq
AbdulAmeer AbdulBari
College of Medicine/University of Basra, Basra, Iraq

Abstract


Introduction: Patients who opt for coronary interventions to help them with their IHD problems face several adverse reactions; the most frequently faced is acute kidney injury from contrast media exposure or contrast induced nephropathy. Those patients have higher mortality and morbidity both in the short and longterm period. The incidence of this adverse reaction in Al-Basra Cardia Center is poorly studied so far. We measured the incidence of AKI in this center and tried to correlate the risk with some important covariates identified by previous researches. Method: this was an observational prospective study. It was a part of the double blind single center study (the effect of spironolactone on the incidence of AKI in patients with Stable IHD admitted for coronary intervention, trial registration: ClinicalTrials.gov NCT03329443). Results: The overall incidence of CIN was 20.2% in this cohort sample. Priori defined high risk variables were tested in univariate logistic regression, and if found to be significant they were to be added to a Multi-Logistic regression model analysis. In Regression analysis only GFR (Log Odds ratio) [0.984 (0.971-0.998)] and Mehran Risk score [Mehran >6 (2.456(1.335-4.519), Mehran >11 (3.931) Mehran >16 (12.366) compared to Mehran <5) were positive in the model analysis. Conclusion: there seems to be a high incidence of AKI in this cohort. Important significant factors include low GFR and a good correlation with Mehran risk score.

Keywords


AKI, Acute Kidney Injury, CIN, Contrast Induced Nephropathy, Angiography, PCI, Percutaneous Coronary Intervention, IHD, Ischemic Heart Disease, CI-AKI, Mehran risk score



DOI: https://doi.org/10.37506/v14%2Fi1%2F2020%2Fijfmt%2F192959